Surface Activity and Emulsification Properties of Hydrophobically Modified Dextrans

‘Surfactant-free’ stable nanoparticles from biodegradable and amphiphilic poly(ε-caprolactone)-grafted dextran copolymers

“…2). Finally, higher molecular area (A) and effectiveness (Π crit = γ crit -γ 0 [33]) are reached for Dex 6,6 -g-76 PCL 0,2 , i.e., for the copolymer with the highest average number of PCL grafts per 100 glucosidic units, which is in good agreement with observations from other similar amphiphilic systems [34,35]. Interestingly enough, a similar behaviour has been recently reported for dextran-gpolylactide copolymers (Dex-g-PLA) [37].…”

Enhancement of the Solubility and Efficacy of Poorly Water-Soluble Drugs by Hydrophobically-Modified Polysaccharide Derivatives

“…They are mainly constituted of hydrophilic and hydrophobic parts. In aqueous solutions, the hydrophilic segments are responsible for the polymer hydration, while the hydrophobic domains minimise their contact with water by self-assembling into aggregates (1)(2)(3)(4)(5)(6)(7)(8)(9). The first studies describing an associative behaviour were published in 1951 with a poly(4-vinylpyridine) derivative bearing ethyl and dodecyl groups (10).…”

Novel carbonyl-group-containing dextran synthesis by pyranose-2-oxidase and dextransucrase

“…Etherification of dextran enables us to control the solubility, hydrophilicity or hydrophobicity, ionic strength, and degradability using the properties of ether moieties. 7 For example, Dellacherie et al prepared an amphiphilic dextran (Dex-P) by introducing aromatic groups, [8][9][10] and Jozefonvicz et al prepared a cation-exchanging dextran (CMD) by carboxymethylation. 11,12 Dex-P and CMD are utilized as nano particles in drug delivery systems (DDS) and as anticoagulants.…”