Enhancement of the Solubility and Efficacy of Poorly Water-Soluble Drugs by Hydrophobically-Modified Polysaccharide Derivatives

Henni-Silhadi, Widad; Deyme, Michel; Boissonnade, Marie-Martine; Appel, M.; Cerf, Didier Le; Picton, Luc; Rosilio, Véronique

doi:10.1007/s11095-007-9461-7

Cited by 34 publications

(14 citation statements)

References 45 publications

(52 reference statements)

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“…Thus, nanogels significantly affected the morphology, viability and proliferation of J774 macrophages, the toxic effect being dose and time dependent and more intense in the batch with lower percentage of grafted hydrophobic alkyl chains. According to the literature, some nanosystems including polymer-based nanoparticles also revealed cytotoxicity specific to this mouse phagocytic cell line, which seems to be quite sensitive to the presence of nanoparticles [16,[46][47][48]. The amphiphilic carboxymethylpullulan solutions reduced the number of viable J774.A1 cells in a time and dose-dependent manner but did not affect MCF-7 cell growth at all concentrations tested [47].…”

Section: Cytocompatibility Of Mannan-c 16 Nanogelmentioning

confidence: 90%

Supramolecular assembled nanogel made of mannan

Ferreira

Pereira

Sampaio

et al. 2011

Journal of Colloid and Interface Science

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The supramolecular assembly of amphiphilic mannan, synthesized by the Michael addition of hydrophobic 1-hexadecanethiol to vinyl methacrylated mannan, originates in aqueous medium the formation of a nanogel, stabilized by hydrophobic interactions among alkyl chains. The critical aggregation concentration, calculated by fluorescence spectroscopy ranged between 0.002 and 0.01 mg/mL, depending on the polymer degree of substitution. The cryo-field emission scanning electron microscopy showed spherical macromolecular micelles with diameters between 100 and 500 nm. The dynamic light scattering analysis revealed a polydisperse colloidal system, with mean hydrodynamic diameter between 50 and 140 nm, depending on the polymer degree of substitution. The nanogel is negatively charged, stable over a 6 months storage period, and stable at pH 3-8, salt or urea solutions. Bovine serum albumin and curcumin were spontaneously incorporated in the nanogel, being stabilized by the hydrophobic domains, opening the possibility for future applications as potential delivery systems for therapeutic molecules. In vitro assays were carried out to characterize the biocompatibility of the nanogel. A toxic effect of mannan-C(16) was observed, specific to mouse macrophage-like cell line J774, not affecting mouse embryo fibroblast cell line 3T3 viability.

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Section: Cytocompatibility Of Mannan-c 16 Nanogelmentioning

confidence: 90%

Supramolecular assembled nanogel made of mannan

Ferreira

Pereira

Sampaio

et al. 2011

Journal of Colloid and Interface Science

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“…For instance, two new hydrophilic anti-cancer drugs, CQMU-0517 and CQMU-0519, were synthesized and studied on antitumor activities in vitro (Henni-Silhadi et al, 2007;Fauzee et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and antitumor activities of folate-decorated docetaxel-loaded human serum albumin nanoparticles

et al. 2014

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Context: Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction, decreased uptake by tumor tissue, and increased exposure to other body compartments.Objective: The present study was aimed at developing hydrosoluble DTX-FA-HSANPs targeting tumor cells and to investigate antitumor activities of the nanoparticles. Materials and methods: The DTX-HSANPs were prepared using a desolvation technique and the carboxylic groups of NHS-folate were conjugated with the amino groups of the human serum albumin nanoparticles, and studied their size and zeta potential, drug loading efficiency, surface morphology, release properties in vitro, and antitumor activities. Moreover, the in vitro antitumor activities of DTX-FA-HSANPs were close to the activities of the positive control (docetaxel). The in vivo inhibition ratios of DTX-FA-HSANPs and docetaxel were 66.2% and 59.5%, respectively, at a dose of 5 mg/kg. Discussion and conclusion: In light of the observed antitumor activities, it would be of considerable interest to collect sufficient data for the clinical application of docetaxel-loaded nanoparticles.

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“…Such polymers or copolymers are usually made of hydrophilic and hydrophobic moieties (blocks or pendent groups) which are able to self associate in aqueous media via intra and/or intermolecular interactions according mainly to the amount and nature of hydrophobic groups and the polymer concentration domain [3][4][5]. These peculiar systems are used as enhancer thickeners [6], in the control of interface [7,8] or more recently in drug delivery applications [9,10]. In this last use, the control of hydrophobic cluster forming is really important.…”

Section: Introductionmentioning

confidence: 99%

Thermo sensitive behavior of cellulose derivatives in dilute aqueous solutions: From macroscopic to mesoscopic scale

Fettaka

Issaadi

Moulai‐Mostefa

et al. 2011

Journal of Colloid and Interface Science

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Enhancement of the Solubility and Efficacy of Poorly Water-Soluble Drugs by Hydrophobically-Modified Polysaccharide Derivatives

Abstract: CMP(49)C(8) is a good candidate for solubilizing hydrophobic drugs and could be applied to docetaxel formulations.

Cited by 34 publications

References 45 publications

Supramolecular assembled nanogel made of mannan

Supramolecular assembled nanogel made of mannan

Preparation, characterization, and antitumor activities of folate-decorated docetaxel-loaded human serum albumin nanoparticles

Thermo sensitive behavior of cellulose derivatives in dilute aqueous solutions: From macroscopic to mesoscopic scale

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