Surface acoustic wave immunosensor based on Au-nanoparticles-decorated graphene fluidic channel for CA125 detection

Zhao, Chenxi; Li, Cuiping; Li, Mingji; Qian, Lirong; Wang, Litian; Li, Hongji

doi:10.1016/j.snb.2022.132063

Cited by 7 publications

(3 citation statements)

References 46 publications

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“…[ 11 ] In addition, pure graphene microtubes were prepared to observe the H 2 O molecule repulsion of the tube wall and the storage effects of electrolytes in the microcavity. [ 12 ] In an early stage, we also developed doped graphene EEG electrodes and confirmed the low R scalp (≈25 kΩ) and EEG response activities of pyrrolic‐N and graphitic‐N phases. [ 13 ] Generally, the R scalp of EEG acquisition is <50 kΩ, which can meet most application requirements.…”

Section: Introductionmentioning

confidence: 77%

Nitrogen‐Doped Multilayer Graphene Microtubes for High‐Density Recording of Occipital EEG Signals

Zhang

Xuan

et al. 2023

Adv Materials Technologies

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The epidermal electroencephalography (EEG) electrodes connect the human brain with the external world and generate braincomputer interfaces (BCIs). [2] BCIs have advanced considerably in the fields of medical treatment, communication, and control. [3] Currently, steady-state visually evoked potential (SSVEP)-based BCI is attracting increasing attention owing to its fast and efficient information transfer rate (ITR). [4] The frequency of an EEG signal evoked by certain stimuli can be analyzed to determine the stimuli that the subject is observing and to obtain the information the user wishes to convey. [5] Human beings exhibit remarkable response only in the limited frequency range of 5-30 Hz. According to literature, the ITR is increased by over 27% when the frequency resolution is optimized from 0.2 to 0.1 Hz. [5a] If the frequency recognition is improved from the epidermal EEG electrodes, more available SSVEP stimulation frequencies can be provided for the target coding design in the online system, and the ITR can be improved substantially.The occipital EEG sensor can be developed as a key component of BCIs with highly effective functions because the occipital region is a brain region with strong, spontaneous, and visually evoked EEG signals. The high-density distribution of small-size electrodes with low scalp-contact impedance (R scalp ) and high signal-to-noise ratio (SNR) can improve the frequency resolution of feedback signals and accurately record EEG with more information compared with conventional electrodes. [6] Graphene derivatives, such as graphene oxide (GO), doped graphene, and multilayer graphene are 2D carbon nanomaterials. [7] Various graphene-based materials have been used in the field of bioelectrical signal collection as a substitute for precious metals owing to their advantageous properties of good conductivity, large specific surface area, high electron mobility, and high biocompatibility. [8] Nevertheless, the exceptionally regular arrangement of the inert carbon plane and its zero bandgap structure limit the further development of graphene. Among the numerous modification approaches, heteroatom doping is a significant technique for regulating the electronic structure and appending additional active sites onto the inert reticular graphene plane. Nitrogen (N)-doping is an effective method to improve biological affinity and enrich active sites. [9] Graphene microelectrodes exhibit potential in recording high-density electroencephalography (EEG) signals from various brain regions. In this study, microtubes composed of nitrogen-doped graphene (NG) nanosheets are synthesized by chemical vapor deposition to record high-density EEG signals. The N-content of the NG samples ranges from 1.35 to 2.22 at.%. One of the fabricated microtubes with an N-content of 2.22% exhibits low scalp-contact resistance and high signal-to-noise ratio (SNR) of EEG signals. The NGmicrotube has the advantages of high water-retention, scalp affinity, water absorption, salt interception, and low resistance; these adva...

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Section: Introductionmentioning

confidence: 77%

Nitrogen‐Doped Multilayer Graphene Microtubes for High‐Density Recording of Occipital EEG Signals

Zhang

Xuan

et al. 2023

Adv Materials Technologies

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“…CA12-5 is also regarded as mucin 16 (MUC16); 5 the level of CA12-5 in human serum is usually lower than 35 U mL −1 . 6 In addition, CA12-5 can also be used as a biomarker in the clinical diagnosis of lung cancer, endometrial cancer, and breast cancer. 7,8 Therefore, the high-sensitivity detection of CA12-5 has crucial clinical significance for these cancers, such as early screening, early diagnosis, and treatment.…”

Section: Introductionmentioning

confidence: 99%

A sensitive electrochemiluminescence immunosensor for carbohydrate antigen 12-5 analysis based on dual-function SnO₂ nanoflowers

Zheng

Qin

et al. 2023

Sens. Diagn.

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“…Biomedical microdevices include integrated structures consisting of numerous micro- and nano-sized integrated devices, where many processes from particle manipulation to sensing take place in the platform. Although different types of microfluidic devices can perform similar tasks in biomedical applications, passive microfluidic systems are mainly used for particle manipulation [ 1 , 2 , 3 , 4 , 5 ] and mixing liquids [ 4 , 6 ], while active types contribute more to particle trapping [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ] and sensing [ 20 , 21 , 22 , 23 , 24 ]. Passive devices are governed by diffusion, inertial forces, secondary flows, and geometry-induced turbulence and particle manipulation; active microfluidic devices generate streams depending on external energy to disturb particles or fluids inside microfluidic devices.…”

Section: Introductionmentioning

confidence: 99%

Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. This review provides a comprehensive overview of the significant advances that have been made in the development of microfluidics devices. We will discuss the function of microfluidic devices as micromixers or as sorters of cells and substances (e.g., microfiltration, flow or displacement, and trapping). Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). An anticipated development in the field includes the optimization of techniques for the fabrication of microfluidic devices using biocompatible materials. These developments will increase biomedical versatility, reduce diagnostic costs, and accelerate diagnosis time of microfluidics technology.

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Surface acoustic wave immunosensor based on Au-nanoparticles-decorated graphene fluidic channel for CA125 detection

Cited by 7 publications

References 46 publications

Nitrogen‐Doped Multilayer Graphene Microtubes for High‐Density Recording of Occipital EEG Signals

Nitrogen‐Doped Multilayer Graphene Microtubes for High‐Density Recording of Occipital EEG Signals

A sensitive electrochemiluminescence immunosensor for carbohydrate antigen 12-5 analysis based on dual-function SnO₂ nanoflowers

Biomedical Applications of Microfluidic Devices: A Review

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Surface acoustic wave immunosensor based on Au-nanoparticles-decorated graphene fluidic channel for CA125 detection

Cited by 7 publications

References 46 publications

Nitrogen‐Doped Multilayer Graphene Microtubes for High‐Density Recording of Occipital EEG Signals

Nitrogen‐Doped Multilayer Graphene Microtubes for High‐Density Recording of Occipital EEG Signals

A sensitive electrochemiluminescence immunosensor for carbohydrate antigen 12-5 analysis based on dual-function SnO2 nanoflowers

Biomedical Applications of Microfluidic Devices: A Review

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A sensitive electrochemiluminescence immunosensor for carbohydrate antigen 12-5 analysis based on dual-function SnO₂ nanoflowers