Suramin treatment in hormone- and chemotherapy-refractory prostate cancer

Garcia-Schürmann, J. M.; Schulze, Harald; Haupt, Gerald; Pastor, J.; Allolio, Bruno; Senge, Theodor

doi:10.1016/s0090-4295(98)00544-5

Cited by 30 publications

(15 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…it is used as a antitrypanosomal agent as well as for the treatment of some (eg, prostatic) tumours. 74 it also has an inhibitory effect on the RT activity of retroviruses and has been used in patients with HiV infection. 75 Suramin inhibits RT by interacting with the template-primer binding site of the enzyme.…”

Section: Suraminmentioning

confidence: 99%

“…76 Suramin is associated with a significant number of severe side effects in humans: nausea and anaphy lactic shock as immediate reactions during administration; peripheral neuritis leading to palmar-plantar hyperaesthesia, photophobia, skin reactions, agranulocytosis, haemolytic anaemia and destruction of the adrenal cortex as later side effects. 74,75,[77][78][79] Severe side effects have to be expected in cats as well.…”

Section: Suraminmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of antiviral chemotherapy for retrovirus-infected cats

Hartmann

2015

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

Section: Suraminmentioning

confidence: 99%

Section: Suraminmentioning

confidence: 99%

Efficacy of antiviral chemotherapy for retrovirus-infected cats

Hartmann

2015

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…Its anticancer activity was later identified, and suramin has been introduced into clinical trials for adrenal, lung, and prostate cancer (35)(36)(37)(38)(39). Moreover, suramin is active against human immunodeficiency virus-1 (40).…”

mentioning

confidence: 99%

Autocrine Growth Factor Regulation of Lysyl Oxidase Expression in Transformed Fibroblasts

Palamakumbura

Sommer

Trackman

2003

Journal of Biological Chemistry

View full text Add to dashboard Cite

Lysyl oxidase catalyzes oxidative deamination of peptidyl-lysine and hydroxylysine residues in collagens and lysine residues in elastin to form peptidyl aldehydes that are required for the formation of covalent crosslinks in normal extracellular matrix biosynthesis. Lysyl oxidase in addition has tumor suppressor activity, and phenotypic reversion of transformed cell lines is accompanied by increased lysyl oxidase expression. The mechanism of low expression of lysyl oxidase in tumor cells is unknown. The present study investigates the hypothesis that autocrine growth factor pathways maintain low lysyl oxidase expression levels in c-H-ras-transformed fibroblasts (RS485 cell line). Autocrine pathways were blocked with suramin, a general inhibitor of growth factor receptor binding, and resulted in more than a 10-fold increase in lysyl oxidase expression and proenzyme production. This regulation was found to be reversible and occurred at the transcriptional level determined using lysyl oxidase promoter/reporter gene assays. Function blocking anti-fibroblast growth factor-2 (FGF-2) antibody enhanced lysyl oxidase expression in the absence of suramin. Finally, the addition of FGF-2 to suramin-treated cells completely reversed suramin stimulation of lysyl oxidase mRNA levels. Data support that an FGF-2 autocrine pathway inhibits lysyl oxidase transcription in the tumorigenic-transformed RS485 cell line. This finding may be of therapeutic significance and, in addition, provides a new experimental approach to investigate the mechanism of the tumor suppressor activity of lysyl oxidase.

show abstract

“…As a surrogate marker of toxicity, animal weights were observed throughout the in vivo study and were not found to be different at autopsy in any group. Other investigators claim that the clinical use of Suramin is limited by its toxicity, which is mainly characterized by the development of a polyneuropathy 27 . As a consequence of Suramin's toxicity, the generation of Suramin analogs is currently being investigated and seems to be a promising approach to circumvent toxic side effects while preserving the advantages of Suramin's antitumor activities 28,29 .…”

Section: Discussionmentioning

confidence: 99%

Suramin Inhibits Not Only Tumor Growth and Metastasis but Also Angiogenesis in Experimental Pancreatic Cancer

Bhargava

Hotz

Hines

et al. 2007

Journal of Gastrointestinal Surgery

View full text Add to dashboard Cite

Suramin inhibits the proliferation of several human tumors in vivo and in vitro. In this study, the effects of Suramin on proliferation and angiogenesis were investigated in human pancreatic cancer cell lines and in an orthotopic nude mouse model of human pancreatic cancer. The effects of Suramin on proliferation, viability, cell cycle, and apoptosis were studied in five human pancreatic cancer cell lines. Suramin inhibited the proliferation of pancreatic cancer cells in a dose-dependent manner and reduced viability at high concentrations. Cell cycle analysis revealed a decreased S-phase fraction in most cell lines, whereas the apoptotic fraction was not notably different. In vivo treatment with Suramin significantly reduced pancreatic tumor size (MiaPaCa-2, -74%; AsPC-1, -41%; and Capan-1, -49%) and metastatic spread (MiaPaCa-2, -79%; AsPC-1, -34%; and Capan, -38%). As a parameter for angiogenic activity, vascular endothelial growth factor (VEGF) secretion was measured, revealing reduced VEGF concentrations under Suramin treatment in both cell culture medium and ascites. Also, microvessel density quantified in primary tumors was reduced in animals treated with Suramin. Therefore, Suramin inhibits the proliferation of human pancreatic cancer in vitro and in vivo. The therapeutic effects seem to involve cell cycle kinetics and may be in part related to the antiangiogenic action of the drug.

show abstract

Suramin treatment in hormone- and chemotherapy-refractory prostate cancer

Cited by 30 publications

References 22 publications

Efficacy of antiviral chemotherapy for retrovirus-infected cats

Efficacy of antiviral chemotherapy for retrovirus-infected cats

Autocrine Growth Factor Regulation of Lysyl Oxidase Expression in Transformed Fibroblasts

Suramin Inhibits Not Only Tumor Growth and Metastasis but Also Angiogenesis in Experimental Pancreatic Cancer

Contact Info

Product

Resources

About