Suramin-Induced Skin Reactions

Abstract

Cutaneous toxicity was a frequent and, often, self-limited side effect of suramin therapy, occurring in 13 (65%) patients. Keratoacanthoma and disseminated superficial actinic porokeratosis have not previously been reported to occur with suramin therapy. The immunosuppressive effect of suramin may induce the keratoacanthoma and disseminated superficial actinic porokeratosis lesions.

The histologic spectrum of epithelial neoplasms induced by sorafenib

“…11,12 Iatrogenic causes include topical photodynamic therapy with 5-aminolevulinic acid, imiquimod, cyclosporine, suramin, psoralen plus ultraviolet A photochemotherapy, ultraviolet B phototherapy, Cook body peel, and polychemotherapy. [13][14][15][16][17][18][19][20][21] The epithelial invaginations in our patient demonstrated a range of keratinocyte atypia, including an AK in his right forearm lesion and an invasive SCC with KA-like architecture on his right shoulder. Both the AK and KA-like SCC bore clinical resemblance to other lesions in our patient.…”

Eruptive disseminated porokeratosis associated with corticosteroid-induced immunosuppression

“…However, the disparity in lesion resolution time and classes of antibiotics used between the cases makes this less likely. In fact, there are reports of other drugs causing EDP, such as anti‐tumour necrosis factor therapy and sumarin, which, although not directly applicable in our patient, should be considered in future cases. As our patient's asthma attack was questionably viral in aetiology, it could be argued that this infection was the nidus for the EDP episode; however, as testing for viral serology is not clinically indicated in such a setting, we can only speculate that this may have been a potential contributor.…”

“…suggested EDP as a new variant of porokeratosis that clinically resembles DSP with a similar distribution of lesions but with a different time evolution. EDP has previously been described in patients with cancer of the liver, colon and pancreas, and also with organ transplant, diabetes mellitus, herpes simplex infection, bone marrow transplant, myelodysplastic syndrome, and both immunosuppressant and nonimmunosuppressant drug therapy. Only one other case of EDP directly attributable to systemic corticosteroid immunosuppression, which was a 75‐year‐old man treated with betamethasone for DSP, has been reported previously.…”

Late-onset disseminated superficial actinic porokeratosis in an elderly woman

“…Drug-induced PK has been rarely reported in the literature. Incriminating drugs were thiazidic derivative, suramine, and antibiotics 10–12. In all reported cases, delay between drug administration and onset of PK was short: between 10 to 15 days.…”