Late-onset disseminated superficial actinic porokeratosis in an elderly woman

Khaled, A.; Kourda, Mouna; Abdelmoula, Fadoua; M’ssedi, Lilia; Tougourti, M. N.; Kamoun, Mohamed Ridha

doi:10.1007/s13555-011-0004-0

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…However, one of them was diagnosed as DSP, and the other one was diagnosed as DSAP. 6,7 We believe that concomitantly developing uncontrolled DM may be the leading cause of EDP in this patient, and to our knowledge, he is the first patient with EDP associated to DM in the literature.…”

Section: Discussionmentioning

confidence: 70%

“…In the case of immunosuppression, expression of a mutant clone of epidermal cells, which may induce porokeratosis, may increase because immune system cannot control or delete that clone. 7,10 In addition to immunosuppressive effect, DM may directly affect keratinocytes as well. It is known that excessive glycation and/or glycoxidation of proteins in keratinocytes in DM may lead to an abnormal proliferation and differentiation of keratinocytes like in patients with DM-induced ichthyosis.…”

Section: Discussionmentioning

confidence: 99%

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Eruptive Disseminated Porokeratosis in a Patient With Type 2 Diabetes Mellitus

Yalçın

Uysal²,

Kadan³

et al. 2016

The American Journal of Dermatopathology

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Porokeratosis includes a group of heterogenous disorders that represents distinct clinical subtypes of the same genetic pattern. Although entire pathogenesis of porokeratosis still remains unknown, certain factors including ultraviolet radiation and immunosuppression are suggested to be some of the factors inducing this disorder. Eruptive disseminated porokeratosis is a recently described form of porokeratosis, which frequently occurs in the presence of immunosuppresion or malignancy. The authors report here a unique case with sudden onset eruptive disseminated porokeratosis associated with diabetes mellitus.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Eruptive Disseminated Porokeratosis in a Patient With Type 2 Diabetes Mellitus

Yalçın

Uysal²,

Kadan³

et al. 2016

The American Journal of Dermatopathology

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“…DSAP is characterized by multiple lesions that are superficial, relatively smaller than the Mibelli type, slightly pigmented, annular, keratotic and with a central atrophic area. It mainly affects areas exposed to sunlight; however, paradoxically, the limbs are more affected than the face [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Disseminated Superficial Actinic Porokeratosis on the Face Treated with Imiquimod 5% Cream

et al. 2013

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Porokeratoses are a group of hereditary or acquired disorders characterized by annular lesions with an atrophic center and a prominent peripheral ridge. Pathologically, porokeratosis is characterized by the presence of abnormal clones of keratinocytes that form a column of parakeratotic cells, called the cornoid lamella. Fifteen percent of patients of disseminated superficial actinic porokeratosis (DSAP) have facial lesions; other regions like the extensor surface of extremities constitute the majority of reported cases. Exclusively facial lesions are probably less frequent. Rarely, actinic porokeratosis is confined to the nose only. Of reported porokeratosis cases, 7.5% have revealed a malignancy arising within the lesion. We present a case of facial sporadic DSAP that was treated with imiquimod 5% cream in conjunction with a regular sunscreen. Follow-up of this case is important to rule out the possibility of malignant transformation of the lesions.

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“…Rarely, DSAP develops bullous [28] or prurigo nodularis-like forms [29]. There are reports of non-actinic DSAP in immunocompromised patients (organ transplant recipients, oncological patients, HIV-positive patients and others) [28,[30][31][32][33][34][35][36][37], pyoderma gangrenosum [34], pseudoxanthoma elasticum [38], dermatomyositis [39], systemic scleroderma [40], Sjögren's syndrome [41], in combination with glioblastoma and Lynch syndrome [42] and during hydroxyurea treatment [43,44].…”

Section: Disseminated Superficial Actinic Porokeratosis (Dsap)mentioning

confidence: 99%

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid–mevalonate pathway.

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Late-onset disseminated superficial actinic porokeratosis in an elderly woman

Cited by 8 publications

References 10 publications

Eruptive Disseminated Porokeratosis in a Patient With Type 2 Diabetes Mellitus

Eruptive Disseminated Porokeratosis in a Patient With Type 2 Diabetes Mellitus

Disseminated Superficial Actinic Porokeratosis on the Face Treated with Imiquimod 5% Cream

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

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