Sur le comportement de la glande pinéale dans des conditions de stress

Miline, R.; Krstić, Radivoj V.; Devecerski, V

doi:10.1159/000143196

Cited by 28 publications

(9 citation statements)

References 4 publications

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“…The results obtained in the morphodynamic field, compared with those obtained in relation to immobilization stress [8] demonstrate the early reac tion of the pineal gland to cold and its participation in the defence processes against this aggressive factor of the environment. They are indicators of the increased activity of the pineal gland under the stress of low temperature.…”

Section: Discussionmentioning

confidence: 86%

“…Our pre vious research results point to the stimulated activity of the pineal gland during hibernation [10]. Analogous results were obtained in the course of correlative behaviour of the pineal gland and of the supraoptic nucleus un der hypothermal stress [11], as well as on the basis of studies of the seasonal rhythm of this endocrinal gland [12], Observations concerning the higher resistance of the organism in hypothermy than in normal condition to various environmental factors on the one hand [1,3,4,15], and the sensitivity of the pineal gland under the influence of aggressive factors on the other [7,8] have encouraged us to study the behaviour of the epithalamo-epiphyseal complex in the syndrome of adap tation to low temperatures. Our aim in the present paper was to present the results of our preliminary research into the behaviour of the pineal gland.…”

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confidence: 99%

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Pineal Gland Behaviour as Affected by Cold

Miline¹,

Devecerski²,

Sijacki³

et al. 1970

Horm Res Paediatr

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The pineal gland of rats exposed to the effect of low temperatures shows structural changes of a progressive nature: hypertrophy and hyperplasia of pineocytes, hypertrophy of nuclei and nucleoli;deprivation of followed by saturation by, pineocytes in sudanophilic granulations; intensified activities of nonspecific esterases, acid phossphatases and alkaline phosphatases; polymorphism and hypertrophy of mitochondria, hypertrophy of the Golgi zone, abundance of free ribosomes. On the basis of the results obtained indicating stimulated activity of the pineal gland, this organ is to be considered as integrated in the regulation system of adaptation to cold.

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Section: Discussionmentioning

confidence: 86%

mentioning

confidence: 99%

Pineal Gland Behaviour as Affected by Cold

Miline¹,

Devecerski²,

Sijacki³

et al. 1970

Horm Res Paediatr

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“…Our studies on the effects of light and darkness upon the histophysiological characteristics of the pineal gland in infantile rabbits and sexually mature rats revealed involutive structural changes under the influence of light and progressive changes under the influence of darkness, unlike the correlative antagonistic reaction of the supraoptic and paraventricular nuclei (Miline, 1957;Miline, 1958). In rats exposed to the effects of noise and vibrations (audiovibratory stress) and in rats affected by immobilization, we found two phases in the histophysiological reaction of the pineal gland: the first phase of involutive structural changes was followed by a phase of stimulated activity (Miline, 1957 a, b;Miline et al, 1966;Miline et al, 1968). The reaction of the pineal gland to emotional stress was studied in hares kept during 14 days aflcer the catch in cages in the presence of hunting dogs.…”

Section: Short Review Of Previous Researchmentioning

confidence: 85%

The role of the pineal gland in stress

Miline¹

1980

J. Neural Transmission

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A short survey of the results of our previous research into the protective role of the pineal gland against stress is given. The neuroendocrine aspect of a chronic auditory stress and the neuroendocrine aspect of ulcer disease in man were studied. Auditory stress: hypertrophy and hyperplasia of pinealocytes, hyperplasia of the STH, FSH, LTH and TSH cells, hypertrophy of the nuclei and nucleoli of the neuroglandular cells of the supraoptic and paraventricular nuclei, pronounced hyperplasia of the cells of the reticular zone of the adrenal gland, involution of the seminal epithelium, hyperplasia of the Leydig cells. Ulcer disease: numerous glial plates, cavities and acervuli in the pineal gland, numerous granules and vacuoles in the FSH cells, large and eccentrical nuclei in the LH cells, hyperplasia of the cells of the reticular zone of the adrenal gland, presence of the seminal tubules marked by signs of involution, hyperplasia of the Leydig cells. The results obtained point to the secretion of androgens and the insufficiency of the antiandrogenic function of the pineal gland both in auditory stress and ulcer disease. The anticancerogenic effect of the pineal gland would be based on its antiandrogenic function.

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“…Previous studies have shown that exposure to cold (3-10 ~ for one day to several weeks increases pinealocyte activity (Quay, I958;Miline et al, 1968Miline et al, , 1970Krstil, 1972;Devegerski, 1972;Bucana et al, 1973;Matsushima and Morisawa, 1978). With respect to melatonin formation variable results have been obtained.…”

Section: Ambient Temperaturementioning

confidence: 99%

The effects of a number of short-term exogenous stimuli on pineal serotonin-N-acetyltransferase activity in rats

Welker

Vollrath

1984

J. Neural Transmission

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The present study deals with the question as to what extent the sympathetically innervated rat pineal gland is affected by a number of short-term exogenous stimuli given during day-time, as assessed by measuring pineal serotonin-N-acetyltransferase activity (NAT) which is directly proportional to melatonin formation. In male Sprague-Dawley rats kept under LD 12:12 pineal NAT was statistically significantly depressed by physical immobilization for 2 hours, swimming for 15 min in water of 10 and 30 degrees C, exposure for 2 hours to cold (5 degrees C) or heat (40 degrees C), noise (90 db) for 2 hours and hunger for 17 hours. An increase in NAT was noted after swimming for 15 min in water of 20 degrees C. No effect was detectable after 17 hours of thirst or hunger combined with thirst and in one of 2 experiments involving exposure to heat (40 degrees C, 2 hours) and insulin-induced hypoglycemia. In animals kept under continuous illumination for 48 hours, immobilization resulted in a slightly smaller decrease than under LD 12:12 and insulin-induced hypoglycemia led to a striking increase of NAT. As the changes in pineal NAT are brought about by rather strong exogenous stimuli it is suspected that the rat pineal gland during day-time is not very susceptible to ambient factors of normal range.

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Sur le comportement de la glande pinéale dans des conditions de stress

Cited by 28 publications

References 4 publications

Pineal Gland Behaviour as Affected by Cold

Pineal Gland Behaviour as Affected by Cold

The role of the pineal gland in stress

The effects of a number of short-term exogenous stimuli on pineal serotonin-N-acetyltransferase activity in rats

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