The role of the pineal gland in stress

Miline, R.

doi:10.1007/bf01250601

Cited by 35 publications

(3 citation statements)

References 13 publications

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“…The pineal organ of small rodents has been shown to exert inhibitory effects on the reproductive and other endocrine systems [Reiter, 1981], The function of the pineal is influenced by photic stimuli [Reiter, 1981], and was shown to be affected by other envi ronmental factors such as temperature [Ralph et al, 1979] and stress [Miline, 1980]. Experiments in rats [Fioretti et al, 1974] sug gested that the pineal may participate in the mechanisms modulating thermal responses.…”

Section: Introductionmentioning

confidence: 99%

Effect of Pinealectomy on Heat-Induced Endocrine Changes in Female Rats

Magal¹,

Kaplanski

Sod‐Moriah³

et al. 1983

Horm Res

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Exposure of pinealectomized rats to high ambient temperature (35 °C; PXH) brought about a diminution in pituitary weight and LH content when compared to their sham-operated peers (35 °C) or to pinealectomized controls (22 °C). Serum corticosterone level of PXH rats was significantly depressed while heat or pinealectomy alone had no effect. Mean oestrous cycle length was prolonged and blood serum progesterone was increased in the heat-exposed rats. However, the extended oestrous cycles and elevated serum progesterone levels of heat-exposed rats were depressed or abolished by pineal ablation. Thus, the pineal appears to exert a moderating effect on heat-induced endocrine changes in female rats. No changes were noticed in uterine and ovarian weights corrected for body weights either on the day of vaginal opening, at occurrence of the oestrous phase expressed as percentage of total oestrous cycle, or in N-acetyltransferase and hydroxyindole-O-methyltransferase activities.

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Section: Introductionmentioning

confidence: 99%

Effect of Pinealectomy on Heat-Induced Endocrine Changes in Female Rats

Magal¹,

Kaplanski

Sod‐Moriah³

et al. 1983

Horm Res

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“…Adrenomedullary catecholamines play a role in the control of gluconeogenesis in the rat, probably by their action on glucose synthesizing enzyme systems in the liver. Miline (1980) demonstrated that various kinds of stress can profoundly change the morphology of the pineal gland. The authors suppose that homeostatic modifications m glucose levels and carbohydrate metabolism following pinealectomy might influence tumour growth.…”

Section: The Influence Of the Pineal On Homeostasis And On Other Endomentioning

confidence: 99%

The role of the pineal gland in neuroendocrine control mechanisms of neoplastic growth

Lapin

Ebels

1981

J. Neural Transmission

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A survey of papers read during a workshop held in Vienna, 1977, is given showing that the pineal gland can be considered a model for research on neuroendocrine control mechanisms in neoplastic growth. From data obtained by different authors it can be concluded that the role of the pineal indole melatonin is very important in regard of the incidence and the development of tumours. On the basis of all the facts mentioned in this paper it is obvious that pineal gland activity should be included into the neuroendocrine factors studied in relation with oncogenic processes. For future research a number of experimental approaches, which need special emphasis, are recommended.

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“…Miline, 1980;Vollrath, 1981). As the effects of nonphotic stimuli have been investigated mostly in chronic experiments (see Discussion), it was decided to assess the relative importance for pineal function of a number of short-term stimuli, in particular as found that pineal NAT activity exhibited a 300-fold increase 2 hours after insulin-induced hypoglycemia and a 100-fold increase after physical immobilization for 2 hours.…”

Section: Introductionmentioning

confidence: 99%

The effects of a number of short-term exogenous stimuli on pineal serotonin-N-acetyltransferase activity in rats

Welker

Vollrath

1984

J. Neural Transmission

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The present study deals with the question as to what extent the sympathetically innervated rat pineal gland is affected by a number of short-term exogenous stimuli given during day-time, as assessed by measuring pineal serotonin-N-acetyltransferase activity (NAT) which is directly proportional to melatonin formation. In male Sprague-Dawley rats kept under LD 12:12 pineal NAT was statistically significantly depressed by physical immobilization for 2 hours, swimming for 15 min in water of 10 and 30 degrees C, exposure for 2 hours to cold (5 degrees C) or heat (40 degrees C), noise (90 db) for 2 hours and hunger for 17 hours. An increase in NAT was noted after swimming for 15 min in water of 20 degrees C. No effect was detectable after 17 hours of thirst or hunger combined with thirst and in one of 2 experiments involving exposure to heat (40 degrees C, 2 hours) and insulin-induced hypoglycemia. In animals kept under continuous illumination for 48 hours, immobilization resulted in a slightly smaller decrease than under LD 12:12 and insulin-induced hypoglycemia led to a striking increase of NAT. As the changes in pineal NAT are brought about by rather strong exogenous stimuli it is suspected that the rat pineal gland during day-time is not very susceptible to ambient factors of normal range.

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The role of the pineal gland in stress

Cited by 35 publications

References 13 publications

Effect of Pinealectomy on Heat-Induced Endocrine Changes in Female Rats

Effect of Pinealectomy on Heat-Induced Endocrine Changes in Female Rats

The role of the pineal gland in neuroendocrine control mechanisms of neoplastic growth

The effects of a number of short-term exogenous stimuli on pineal serotonin-N-acetyltransferase activity in rats

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