Supratentorial and cerebellar liponeurocytomas: report of four cases with review of literature

Abstract

Liponeurocytoma is not exclusive to the cerebellar or fourth ventricular location. Since its inclusion in the central nervous system tumor classification in 2000, six cases with similar radiological, histomorphological and immunohistochemical features have also been described in the lateral ventricles. In the present study, we report clinical, radiological and pathological findings of three supratentorial and one cerebellar liponeurocytoma from our records, evaluated with an extensive panel of immunohistochemistry, and review published cases in the literature. The immunohistochemical pattern of supratentorial and infratentorial liponeurocytomas are almost identical, which indicates that these tumors are homologous.

Does “cerebellar liponeurocytoma” always reflect an expected site? An unusual case with a review of the literature

“…The immunostaining profile of previously published cases of supratentorial liponeurocytomas demonstrates uniform reactivity for neuronal markers like synaptophysin, and/or NSE as was seen in the present case [2,[4][5][6]9,11,13,15]. Expression of GFAP and S-100 is limited to scattered reactive astrocytes [4,9,15], and a few tumour cells [2,5,11,13].…”

“…Linking the concept of liponeurocytoma to its occurrence in the cerebellum unnecessarily obscures the existence of similar neoplasms at other sites. Indeed ten such cases have been reported in the English literature (Table I) [2,[4][5][6]9,11,13,15]. We herein present the eleventh example of supratentorial intraventricular liponeurocytoma (Table I).…”

“…Immunohistochemical staining demonstrated both neuronal and glial differentiation. Histologically mitotic activity and proliferation rate are generally low in these lesions [2,10,14,16].…”

“…Tumours with features of liponeurocytoma have also been observed in supratentorial locations. There have been approximately 40 reported cases of cerebellar and 10 cases of supratentorial liponeurocytoma in the literature [2,[4][5][6]9,11,13,15]. The tumour usually has a favourable clinical prognosis, although recurrences are frequent [3,8].…”

Multifocal Cerebellar Liponeurocytoma

“…14 We have described a case of a cerebellar liponeurocytoma with characteristic radiological and pathological findings, except for a unique, separate satellite lesion at presentation. To our knowledge, a multifocal liponeurocytoma has not been previously reported.…”