Supramolecular structure of chitin nanofibrils

Dobrovol’skaya, I. P.; Kasatkin, Igor; Yudin, V. E.; Иванькова, Е. М.; Elokhovskii, V. Yu.

doi:10.1134/s0965545x15010022

Cited by 16 publications

(5 citation statements)

References 14 publications

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“…Obviously, chitosan films have the highest sorption capacity with respect to water vapour, which may occur due to the presence of polar functional groups and a more labile and less ordered structure of macromolecules. Chitin, characterized by a more ordered structure and high crystallinity [10], has the lowest sorptive power. For composite films, the sorption value decreases with increasing chitin content in the films, although the contributions of the individual components are not additive.…”

Section: Resultsmentioning

confidence: 99%

“…The molecular mass (M m ) of chitosan was 1.64 × 10 5 g/mol and the degree of deacetylation (DD) was 92%. The diameter of chitin nanofibrils was 20 ± 4 nm and the length was 700 ± 100 nm [10,14]. For evaluating the effect of the film matrix on the properties of the composite films, chitosan with a similar M m of 1.4 × 10 5 g/mol but a lower DD of 80% was used (Sigma Aldrich, St. Louis, MO, USA).…”

Section: Methodsmentioning

confidence: 99%

“…One of the biocompatible, bioactive, and bioresorbable polymers is chitin, which can be successfully used as a filler. The main structural units of chitin are nanofibrils; they are highly oriented macromolecular aggregates with transverse sizes of 15–20 nm and longitudinal sizes of 400–500 nm [10]. This structure provides a high mechanical strength of natural chitin-containing tissues.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering

et al. 2019

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This paper discusses the mechanical and physicochemical properties of film matrices based on chitosan, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It is shown that with the introduction of chitin nanofibrils as a filler, the mechanical stability of the composite materials increases. By varying the concentration of chitin nanofibrils, it is possible to obtain a spectrum of samples with different bioactive properties for the growth of human dermal fibroblasts. Film matrices based on the nanocomposite of chitosan and 5 wt % chitin nanofibrils have an optimal balance of mechanical and physicochemical properties and bioactivity in relation to the culture of human dermal fibroblasts.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering

et al. 2019

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“…The method of obtaining these fibers is explained in [ 44 , 45 ]. Their structure was described in the work [ 46 ].…”

Section: Methodsmentioning

confidence: 99%

Properties of Resorbable Conduits Based on Poly(L-Lactide) Nanofibers and Chitosan Fibers for Peripheral Nerve Regeneration

Tagandurdyyeva,

Trube,

Shemyakin

et al. 2023

Polymers

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New tubular conduits have been developed for the regeneration of peripheral nerves and the repair of defects that are larger than 3 cm. The conduits consist of a combination of poly(L-lactide) nanofibers and chitosan composite fibers with chitin nanofibrils. In vitro studies were conducted to assess the biocompatibility of the conduits using human embryonic bone marrow stromal cells (FetMSCs). The studies revealed good adhesion and differentiation of the cells on the conduits just one day after cultivation. Furthermore, an in vivo study was carried out to evaluate motor-coordination disorders using the sciatic nerve functional index (SFI) assessment. The presence of chitosan monofibers and chitosan composite fibers with chitin nanofibrils in the conduit design increased the regeneration rate of the sciatic nerve, with an SFI value ranging from 76 to 83. The degree of recovery of nerve conduction was measured by the amplitude of M-response, which showed a 46% improvement. The conduit design imitates the oriented architecture of the nerve, facilitates electrical communication between the damaged nerve’s ends, and promotes the direction of nerve growth, thereby increasing the regeneration rate.

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“…As a result, the water insoluble chitin is converted into soluble chitosan. Because of the wound healing, anti-inflammatory and antibacterial properties of both chitin and chitosan, attempts have been made to use these materials for a range of applications (Ding et al, 2015;Abbas Teimouri & Azadi, 2016) including wound dressings (Huang et al, 2014;Xie, Khajanchee, Teach, & Shaffer, 2008), surgical sutures (Dobrovol'skaya, Kasatkin, Yudin, Ivan'kova, & Elokhovskii, 2015;Khor & Lim, 2003), and as scaffolds in tissue engineering (Dhivya, Saravanan, Sastry, & Selvamurugan, 2015;Liu, Ma, Mao, & Gao, 2011). In particular, chitin and chitosan can promote fibroblast proliferation and macrophage migration, and accelerate vascularization and granulation during wound healing processes (Riccardoaa, 2009).…”

Section: Introductionmentioning

confidence: 99%

Regenerated chitin fibers reinforced with bacterial cellulose nanocrystals as suture biomaterials

Williams

et al. 2018

Carbohydrate Polymers

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The objective of this work was to prepare a novel filament with good biocompatibility and mechanical performance which can meet the demands of surgical sutures. Bacterial cellulose nanocrystals (BCNCs) were used to reinforce regenerated chitin (RC) fibers to form BCNC/RC filaments. Mechanical performance measurements demonstrated that the strength of the BCNC/RC filament was increased dramatically over the RC analogue. A yarn made of 30 BCNC-loaded fibers also achieved satisfactory mechanical performance, with a knot-pull tensile strength of 9.8±0.6N. Enzymatic degradation studies showed the BCNC/RC materials to have good biodegradability, the rate of which can be tuned by varying the concentration of BCNCs in the yarn. The RC and the BCNC/RC materials had no cytotoxicity and can promote cell proliferation. In vivo experiments on mice demonstrated that suturing with the BCNC/RC yarn can promote wound healing without obvious adverse effects.

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Supramolecular structure of chitin nanofibrils

Cited by 16 publications

References 14 publications

Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering

Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering

Properties of Resorbable Conduits Based on Poly(L-Lactide) Nanofibers and Chitosan Fibers for Peripheral Nerve Regeneration

Regenerated chitin fibers reinforced with bacterial cellulose nanocrystals as suture biomaterials

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