Supramolecular self-assembling peptides to deliver bone morphogenetic proteins for skeletal regeneration

Chen, Charlotte H.; Hsu, Erin L.; Stupp, Samuel I.

doi:10.1016/j.bone.2020.115565

Cited by 27 publications

(24 citation statements)

References 189 publications

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“…Previous studies have mainly focused on improving surgical techniques [ 4 , 9 , [20] , [21] , [22] , [23] , [24] , [25] ]; however, only a few studies have attempted to improve the gap integration of grafts following mosaicplasty using a tissue engineering approach. In the tissue engineering field, natural growth factor-loaded hydrogel scaffolds have been proved to improve cell viability and osteochondral regeneration [ [26] , [27] , [28] , [29] , [30] ]. However, because they are easily inactivated, it is difficult to maintain their biological activity when combined with scaffold materials, which greatly hinder their long-term effects in vivo [ [31] , [32] , [33] , [34] ].…”

Section: Introductionmentioning

confidence: 99%

Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl (BSN-GelMA) hydrogel

Shang

Sun

et al. 2023

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl (BSN-GelMA) hydrogel

Shang

Sun

et al. 2023

Bioactive Materials

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“… 16 − 18 These peptide amphiphiles are generally composed of alternating hydrophobic alkyl chains and hydrophilic amino acid residues, which spontaneously form well-organized assemblies ranging from nanoscale to macroscopic 3D isotropic or anisotropic hydrogels. 16 Isotropic hydrogels, developed from peptide amphiphiles combined with epitopes 19 − 22 or growth factors 23 , 24 or mimicked bioactive sequences, 25 − 29 have been used to mimic the ECM, showing possible clinical applications in bone therapy; 27 , 30 brain, 31 kidney, 32 and central nervous system injury; 33 cartilage regeneration; 34 and angiogenesis. 35 , 36 Compared to isotropic hydrogels, anisotropic hydrogels with hierarchically high-oriented structures are considered a particularly attractive class of ECM mimetic scaffold for regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%

Photoactuating Artificial Muscles of Motor Amphiphiles as an Extracellular Matrix Mimetic Scaffold for Mesenchymal Stem Cells

et al. 2022

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Mimicking the native extracellular matrix (ECM) as a cell culture scaffold has long attracted scientists from the perspective of supramolecular chemistry for potential application in regenerative medicine. However, the development of the next-generation synthetic materials that mimic key aspects of ECM, with hierarchically oriented supramolecular structures, which are simultaneously highly dynamic and responsive to external stimuli, remains a major challenge. Herein, we present supramolecular assemblies formed by motor amphiphiles ( MAs ), which mimic the structural features of the hydrogel nature of the ECM and additionally show intrinsic dynamic behavior that allow amplifying molecular motions to macroscopic muscle-like actuating functions induced by light. The supramolecular assembly (named artificial muscle) provides an attractive approach for developing responsive ECM mimetic scaffolds for human bone marrow-derived mesenchymal stem cells ( hBM-MSCs ). Detailed investigations on the photoisomerization by nuclear magnetic resonance and UV–vis absorption spectroscopy, assembled structures by electron microscopy, the photoactuation process, structural order by X-ray diffraction, and cytotoxicity are presented. Artificial muscles of MAs provide fast photoactuation in water based on the hierarchically anisotropic supramolecular structures and show no cytotoxicity. Particularly important, artificial muscles of MAs with adhered hBM-MSCs still can be actuated by external light stimulation, showing their ability to convert light energy into mechanical signals in biocompatible systems. As a proof-of-concept demonstration, these results provide the potential for building photoactuating ECM mimetic scaffolds by artificial muscle-like supramolecular assemblies based on MAs and offer opportunities for signal transduction in future biohybrid systems of cells and MAs .

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“…Although bone tissue can undergo self-healing during bone repair, critical bone defects caused by severe fracture, tumor excision, congenital defects, arthritis, and osteoporosis remain a global concern because regenerative requirement exceeds the bone's capacity to heal itself [ 1 , 2 ]. Autologous bone grafting is the gold standard for surgical bone repair, but it is limited because of potential complications, including chronic pain, infections, and hematomas [ 3 , 4 ]. Allogenic bone grafting and xenogenic bone grafting are alternative approaches for critical bone defects, but they show predominant disadvantages, including high costs and risks of disease transmission and immune rejection [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem Cell–Immune Cell Interaction and Related Modulations for Bone Tissue Engineering

Chen

Hao

Wang

et al. 2022

Stem Cells International

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Critical bone defects and related delayed union and nonunion are still worldwide problems to be solved. Bone tissue engineering is mainly aimed at achieving satisfactory bone reconstruction. Mesenchymal stem cells (MSCs) are a kind of pluripotent stem cells that can differentiate into bone cells and can be used as one of the key pillars of bone tissue engineering. In recent decades, immune responses play an important role in bone regeneration. Innate immune responses provide a suitable inflammatory microenvironment for bone regeneration and initiate bone regeneration in the early stage of fracture repair. Adaptive immune responses maintain bone regeneration and bone remodeling. MSCs and immune cells regulate each other. All kinds of immune cells and secreted cytokines can regulate the migration, proliferation, and osteogenic differentiation of MSCs, which have a strong immunomodulatory ability to these immune cells. This review mainly introduces the interaction between MSCs and immune cells on bone regeneration and its potential mechanism, and discusses the practical application in bone tissue engineering by modulating this kind of cell-to-cell crosstalk. Thus, an in-depth understanding of these principles of bone immunology can provide a new way for bone tissue engineering.

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Supramolecular self-assembling peptides to deliver bone morphogenetic proteins for skeletal regeneration

Cited by 27 publications

References 189 publications

Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl (BSN-GelMA) hydrogel

Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl (BSN-GelMA) hydrogel

Photoactuating Artificial Muscles of Motor Amphiphiles as an Extracellular Matrix Mimetic Scaffold for Mesenchymal Stem Cells

Mesenchymal Stem Cell–Immune Cell Interaction and Related Modulations for Bone Tissue Engineering

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