Supramolecular nanomedicine derived from cucurbit[7]uril-conjugated nano-graphene oxide for multi-modality cancer therapy

Ding, Yuan‐Fu; Kwong, Cheryl H. T.; Li, Shengke; Pan, Yating; Wei, Jianwen; Wang, Lianhui; Mok, Greta S. P.; Wang, Ruibing

doi:10.1039/d1bm00426c

Cited by 27 publications

(38 citation statements)

References 28 publications

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“…Although it is difficult to make a comparison among the different systems used for the evaluation of antitumor efficiency using various nanomaterials, the covalently functionalized GO–FA/Ce6 showed a higher photocytotoxicity at a lower dose compared to other similar studies using GO–Ce6-based conjugates [ 29 , 56 , 57 ]. For example, our GO–FA/Ce6 showed a combined PTT and PDT anticancer efficiency on MCF-7 cells comparable to the cucurbit[7]uril–NGO–Ce6–oxaliplatin–hyaluronic acid nanocomplex (CNGH OX ) on murine melanoma B16 cells [ 56 ]. However, the amount of Ce6 was much higher in CNGH OX (5 μg·mL −1 vs. 45 ng·mL −1 in our GO–FA/Ce6), alerting to the fact that side effects of chemotherapy should be considered.…”

Section: Resultsmentioning

confidence: 95%

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Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide

Guo

Zhang

et al. 2022

Pharmaceutics

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Graphene oxide (GO) is one of the most studied nanomaterials in many fields, including the biomedical field. Most of the nanomaterials developed for drug delivery and phototherapies are based on noncovalent approaches that lead to an unspecific release of physisorbed molecules in complex biological environments. Therefore, preparing covalently functionalized GO using straightforward and versatile methods is highly valuable. Phototherapies, including photothermal therapy (PTT) and photodynamic therapy (PDT), have shown great potential as effective therapeutic approaches against cancer. To overcome the limits of a single method, the combination of PTT and PDT can lead to a combined effect with a higher therapeutic efficiency. In this work, we prepare a folic acid (FA) and chlorin e6 (Ce6) double-functionalized GO for combined targeted PTT/PDT. This conjugate can penetrate rapidly into cancer cells and macrophages. A combined effect of PTT and PDT is observed, leading to a higher killing efficiency toward different types of cells involved in cancer and other diseases. Our work provides a simple protocol to prepare multifunctional platforms for the treatment of various diseases.

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Section: Resultsmentioning

confidence: 95%

“…Comparatively, we obtained a similar or higher therapeutic efficiency while using a lower dose of conjugate (based on Ce6 equivalent.) [ 56 , 60 ]. Additionally, an inappropriate covalent functionalization may also lead to lower phototherapeutic efficiency.…”

Section: Resultsmentioning

confidence: 99%

Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide

Guo

Zhang

et al. 2022

Pharmaceutics

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“…Additionally, the AQ4N prodrug had augmented the hypoxic effect upon its activation following excitation of the photosensitizer (where the hypoxia-inducible factor HIF-α protein was also overexpressed). 51 The in vitro cytotoxic effect of the developed nanosystem was investigated against B16 melanoma cancer cells and compared to the free and coloaded guests, after 6 h of incubation then irradiated by PDT/PTT and then incubated for additional 18 h. B16 cell viability decreased by 90% when treated with the nanocomplex (coloaded with Ce6, AQ4N, and OxPt), compared to a 70% reduction when treated with the nanocomplex (coloaded with Ce6 and OxPt), following both PTT/PDT. Additionally, the cell viability was reduced by 50% when treated with the complex (loaded with OxPt), compared to a 15% of reduction with the nanocomplex (no drugs loaded), following PTT only treatment.…”

Section: Cb-based Stimuli-responsive Nanovesicles Inmentioning

confidence: 99%

Stimuli-Responsive Cucurbit[n]uril-Based Supramolecular Nanocarriers for Delivery of Chemotherapeutics

Alabrahim

Fahmy²,

Azzazy

2023

ACS Appl. Nano Mater.

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Chemotherapeutics commonly exhibit low bioavailability and systemic adverse effects. Supramolecular nanovesicles, such as pillar[n]arenes, calix[n]arenes, cucurbit[n]urils (CBs), and cyclodextrins, have been introduced as promising nanocarriers due to their remarkable encapsulation capacity and ability to host hydro-philic/-phobic guest molecules. Additionally, such nanovesicles can be decorated with various stimuli-responsive entities to enable drug targeting and controlled drug release. Self-assembly of amphiphilic cavitands and host−guest complexation represent the two common approaches for preparation of supramolecular nanovesicles with customizable surfaces capable of accommodating different biologically active guest molecules. CBs have been used as smart and multifunctional host macromolecules in cancer therapy. CBs are fabricated via a condensation reaction between formaldehyde and glycoluril units generating barrel-shaped supramolecules with partially enclosed cavities. The unique structure of CBs surrounding an internal hydrophobic cavity allows them to accommodate cationic and neutral guest molecules via ion-dipole and hydrophobic interactions, respectively. Additionally, CBs are stable, safe, and biocompatible, and their surfaces can be decorated with various functional targeting moieties. These advantages have promoted CBs as promising candidates for stimuli-responsive targeted delivery of chemotherapeutics. This review presents the most recent advances in the design of stimuli-responsive nanosystems based on CBs for effective cancer treatment.

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“…Various studies have been conducted to control microorganisms through methods such as photodynamic therapy (PDT) and photothermal therapy (PTT). [ 16 , 17 ] However, these antimicrobial therapy methods have their shortcomings such as limited selectivity of treating sites, low efficiency, and causing tissue damage due to high temperature and lighting effects. [ 18 ] Sonodynamic therapy (SDT) is triggered by ultrasound (US), which has many characteristics including deep tissue penetration, non‐invasion and non‐ionization.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity

et al. 2022

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To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through electrical stimulation with an ultrasound (US)‐driven implantable, biodegradable, and vibrant triboelectric nanogenerator (IBV‐TENG). After a programmed lifetime, the IBV‐TENG can be eliminated by provoking the on‐demand device dissolution by controlling US intensity with no surgical removal of the device from the body. A voltage of ≈4 V and current of ≈22 µA generated from IBV‐TENG under ultrasound in vitro, confirming inactivating ≈100% of Staphylococcus aureus and ≈99% of Escherichia coli . Furthermore, ex vivo results show that IBV‐TENG implanted under porcine tissue successfully inactivates bacteria. This antibacterial technology is expected to be a countermeasure strategy against SSIs, increasing life expectancy and healthcare quality by preventing microorganisms of deep tissue.

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Supramolecular nanomedicine derived from cucurbit[7]uril-conjugated nano-graphene oxide for multi-modality cancer therapy

Abstract: Nano-graphene oxide (NGO) has attracted increasing attentions as advanced drug delivery systems. However, the current surface functionalization and drug-loading of NGO either relies on π−π stacking that is limited to...

Cited by 27 publications

References 28 publications

Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide

Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide

Stimuli-Responsive Cucurbit[n]uril-Based Supramolecular Nanocarriers for Delivery of Chemotherapeutics

Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity

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