Supramolecular Nanofibrillar Thermoreversible Hydrogel for Growth and Release of Cancer Spheroids

Li, Yunfeng; Khuu, Nancy; Gevorkian, Albert; Sarjinsky, Sharon; Thérien-Aubin, Héloı̈se; Wang, Yihe; Cho, Sangho; Kumacheva, Eugenia

doi:10.1002/ange.201610353

Cited by 14 publications

(14 citation statements)

References 46 publications

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“…For this purpose, BT474 cells were again chosen and treated for 72 h with 0.042 mg/mL of 115 nm PD NPs, which were the NPs and the concentration that had previously reduced the survival of the breast carcinoma cell line the furthest. 24, 48 and 72 h after treatment, these cells were stained with calcein AM and propidium iodide (PI), and the resulting images are shown below in Figure 4 [39,40,41]. As can be observed, the survival rate of BT474 cells was reduced to 74% after the first 24 h of treatment and, after 48 and 72 h, 57% and 48% of the breast cancer cells remained alive, with these survival rates being similar to those that had been obtained when MTT assays were carried out previously (Figure 2a and Figure S1a).…”

Section: Resultsmentioning

confidence: 99%

Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors

Nieto

Vega

Enrique

et al. 2019

Cancers

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Polydopamine has acquired great relevance in the field of nanomedicine due to its physicochemical properties. Previously, it has been reported that nanoparticles synthetized from this polymer are able to decrease the viability of breast and colon tumor cells. In addition, it is well known that the size of therapeutic particles plays an essential role in their effect. As a consequence, the influence of this parameter on the cytotoxicity of polydopamine nanoparticles was studied in this work. For this purpose, polydopamine nanoparticles with three different diameters (115, 200 and 420 nm) were synthetized and characterized. Their effect on the viability of distinct sorts of human carcinomas (breast, colon, liver and lung) and stromal cells was investigated, as well as the possible mechanisms that could be responsible for such cytotoxicity. Moreover, polydopamine nanoparticles were also loaded with doxorubicin and the therapeutic action of the resulting nanosystem was analyzed. As a result, it was demonstrated that a smaller nanoparticle size is related to a more enhanced antiproliferative activity, which may be a consequence of polydopamine’s affinity for iron ions. Smaller nanoparticles would be able to adsorb more lysosomal Fe3+ and, when they are loaded with doxorubicin, a synergistic effect can be achieved.

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Section: Resultsmentioning

confidence: 99%

Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors

Nieto

Vega

Enrique

et al. 2019

Cancers

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“…When the frequency was 6.28 rad s –1 , both hydrogels displayed linear viscoelastic behavior at 1–90% stain of PC 10 A hydrogel and 1–50% stain of PC 10 A‐QD hydrogel ( Figure A). The storage modulus G′ was at least five times greater than the loss modulus G″, and the G′ and G″ values were independent of the strain within their corresponding regimes . At strain of PC 10 A hydrogel >90% and strain of PC 10 A‐QD hydrogel >80%, G′ value decreased with increasing of strain, and both hydrogels showed nonlinear viscoelastic behavior.…”

Section: Methodsmentioning

confidence: 99%

An Injectable Self‐Healing Multifluorescent Hydrogel Formed by Engineered Coiled‐Coil Polypeptide and Quantum Dots

Yang

Zhao

Jin

et al. 2019

Macro Materials & Eng

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An injectable and self‐healing multifluorescent hydrogel system based on engineered coiled‐coil polypeptide and CdSe@ZnS quantum dots (QDs) is developed. The mechanical properties of the PC10A‐QD hydrogel are able to be tuned by changing the concentrations of PC10A and QDs. The G′ of PC10A hydrogel increases from 800 to 1000 Pa by doping 6 nm oil‐soluble CdSe@ZnS QDs. The PC10A‐QD hydrogel can easily pass through a 26‐gauge needle without clogging. In addition, through interfacial assembly of PC10A polypeptide on the surface of the PC10A‐QD hydrogel, each of these hydrogel can self‐assemble into a multifluorescent hydrogel. This approach for preparation of injectable self‐healing multifluorescent hydrogels is expected to apply in biomedicine.

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“…The benefits of supramolecular hydrogels comprise control over the physicochemical and structural properties in a dynamic, reversible, and biomimetic manner. Under specific stimuli conditions, such as the light, [ 15 , 16 , 17 ] temperature, [ 18 , 19 ] pH, [ 20 , 21 , 22 ] and redox, [ 22 , 23 ] the supramolecular hydrogel systems instigate their motions and structures to release encapsulated cargos in the targeted site.…”

Section: Introductionmentioning

confidence: 99%

Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release

2021

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Herein, poly (n-(4-aminophenyl) methacrylamide)) carbon nano-onions (PAPMA-CNOs = f-CNOs) and γ-cyclodextrin/DOX-complex (CD) reinforced gelatin methacryloyl (GelMA)/f-CNOs/CD supramolecular hydrogel interfaces were fabricated using the photo-crosslinking technique. The physicochemical properties, morphology, biodegradation, and swelling properties of hydrogels were investigated. The composite hydrogels demonstrated enriched drug release under the acidic conditions (pH 4.5 = 99%, and pH 6.0 = 82%) over 18 days. Owing to the f-CNOs inclusion, GelMA/f-CNOs/CD supramolecular hydrogels presented augmented tensile strength (σult = 356.1 ± 3.4 MPa), toughness (K = 51.5 ± 0.24 Jg−1), and Young’s modulus (E = 41.8 ± 1.4 GPa). The strengthening of GelMA/f-CNOs/CD hydrogel systems indicates its good dispersion and the degree of polymer enveloping of f-CNOs within GelMA matrixes. Furthermore, the obtained hydrogels showed improved cell viability with human fibroblast cells. Nevertheless, the primed supramolecular hydrogels would pave the way for the controlled delivery systems for future drug delivery.

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Supramolecular Nanofibrillar Thermoreversible Hydrogel for Growth and Release of Cancer Spheroids

Cited by 14 publications

References 46 publications

Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors

Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors

An Injectable Self‐Healing Multifluorescent Hydrogel Formed by Engineered Coiled‐Coil Polypeptide and Quantum Dots

Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release

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