Supramolecular Inhibition of Amyloid Fibrillation by Cucurbit[7]uril

Abstract

Scheme 1. The structure of cucurbit[7]uril (CB[7]).

Stimuli‐Responsive Cucurbit[7]uril‐Mediated BSA Nanoassembly for Uptake and Release of Doxorubicin

“…[2,3] Recognition-mediated nanoassembly approaches have proven very effective in camouflaging andr estoring the active protein structures, and controlling the protein misfolding and aggregation. [2,6,7] This could, in turn, preventn eurodegeneratived iseases such as Alzheimer's disease, Parkinson's disease, Prion diseases, etc. [6] An umber of synthetic macrocyclic host molecules including cyclodextrin, cucurbituril,c alixarene, etc.…”

“…[2,6,7] This could, in turn, preventn eurodegeneratived iseases such as Alzheimer's disease, Parkinson's disease, Prion diseases, etc. [6] An umber of synthetic macrocyclic host molecules including cyclodextrin, cucurbituril,c alixarene, etc. have been employed to engineer the surfaceo fp rotein molecules, as these macrocycles have been established to be biocompatible.…”

Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranose on Amyloid β25–35 Assembly

“…32,39–41 For example, cucurbit[7]uril (CB[7]) (see Scheme 1), a synthetic macrocyclic receptor molecule, 42–44 has demonstrated inhibitory effects by locking aromatic residues inside its hollow core. 40 Each cucurbituril possesses a rigid hydrophobic cavity lying between the two oxygen-atom-rich rims, making it a compatible structure for host-guest chemistry. 45 The inhibitory effect of CB[7] on A β aggregation was suggested to be associated primarily with its hydrophobic cavity capable of capturing aromatic residues.…”

Photocaged Competitor Guests: A General Approach Toward Light‐Activated Cargo Release From Cucurbiturils

“…In this contextcucurbit[n]urils (CBn) are an emerging family of all-organic macrocyclic hosts [10,11] that featureh igh guesta ffinities( generally in the range of 10 5 -10 10 Lmol À1 ;e xceptionally up to 10 17 Lmol À1 )a nd selective bindingo fs tructurallyd iverse molecules in aqueous solution. [11][12][13][14] They are exploitedf or example for drug delivery, [15][16][17] monitoring/control of biological processes (for example,e nzymatic catalysis), [18][19][20][21] and biomolecule modification, [22][23][24][25] but also for the design of sensors and switches. [26][27][28][29][30][31][32][33][34] As part of our own research program we recently demonstratedt he photorelease of guests from CB7 complexes by a light-induced pH-jumpo rb yc ouplingo fa(pH-dependent) flavylium photoswitch to the host-guest equilibrium of ac ucurbituril complex.…”