Supramolecular Hydrogels Based on Cyclodextrins: Progress and Perspectives

Abstract

Hydrogels have emerged as one of the best studied, widely applied and most versatile classes of soft materials. Hydrogels are important biomimetic nanomaterials comparable to extracellular matrices in terms of water content, porosity, and rigidity. In this regard, self‐assembled hydrogels based on supramolecular host‐guest interactions have enabled unique characteristics like stimuli response, self‐healing, shape memory and self‐regulation. In particular, the use of cyclodextrins and their host‐guest chemistry is a powerful tool for the development of functional hydrogels with unprecedented properties. In this article, recent advances on hydrogels based on supramolecular chemistry of cyclodextrins are reviewed to provide an overview of the manifold design strategies, material properties and areas of application. We contrast the progress on cyclodextrin containing polymer gels to that of their low molecular weight counterparts by highlighting selected publications from each of these subcategories.

Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles

“…These properties facilitate high conversions between the two isomeric forms, while their long-half-lives allow their metastable and assembled structures to be studied and deployed in applications. The arylazopyrazole’s improved photoswitching properties, paired with the greater structural change of the two isomeric forms, , render them as ideal candidates to incorporate into photosurfactants. ,− Despite showing promise in controlling the assembly of supramolecular structures, − relatively few studies have exploited the use of these azoheteroarenes. Specifically, an investigation into the key changes in aggregation behavior occurring between the isomeric states of arylazopyrazoles has not yet been conducted.…”

Synthesis and Hemolytic Activity of Bile Acid-Indole Bioconjugates Linked by Triazole

“…Therefore, they are likely to be biologically active compounds. 11). Propargyl lithocholate (or deoxycholate and cholate) (7.23 mmol, 1.0 equiv) was dissolved in 20 mL of HCOOH (90%) and heated at 60 °C in a water bath for 4 h. The reaction was monitored by TLC.…”

Green materials with promising applications: cyclodextrin-based deep eutectic supramolecular polymers

“…65 The structural water-induced DESP adhesive material is gel-like at room temperature and hardly has the fluidity expected of a DES due to the irreversible loss of structural water from the structure of the polymer after heating. 66,67 Microscopically, instead of direct hydrogen bonding between the two precursors of the DESP adhesives, H 2 O induces two kinds of precursors to polymerize through hydrogen bonding to form a supramolecular hydrogen bonding network. Most of the water is removed after the supramolecular structure is formed, which significantly reduces the material's fluidity and ability to dissolve compounds.…”