Supramolecular host-guest interaction of antibiotic drug ciprofloxacin with cucurbit[7]uril macrocycle: Modulations in photophysical properties and enhanced photostability

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

“…In the fields of pharmacy, medicine, and nutrition, there are several macrocycle molecules that have been used for improving the solubility of the active ingredient of drugs and their stability and bioavailability for the determination of proteins and nucleic acids. They have even exhibited biological activity or value in sensitization therapies, as seen for example with cucurbit[ n ]urils [1], macrocyclic tetrapyrazolics [2], resorcinarenes [3], crown ethers [4], cyclodextrins [5], phthalocyanines [6], and calixarenes [7], among others. All of this has been possible due to the fact that these compounds are able to form a complex with molecules of biological interest such as antibiotics [1], proteins and nucleic acids [4], food nutraceuticals [5], and cholesterol [7], among many other compounds.…”

“…They have even exhibited biological activity or value in sensitization therapies, as seen for example with cucurbit[ n ]urils [1], macrocyclic tetrapyrazolics [2], resorcinarenes [3], crown ethers [4], cyclodextrins [5], phthalocyanines [6], and calixarenes [7], among others. All of this has been possible due to the fact that these compounds are able to form a complex with molecules of biological interest such as antibiotics [1], proteins and nucleic acids [4], food nutraceuticals [5], and cholesterol [7], among many other compounds. In particular, the calixarenes are able to form a guest–host inclusion complex with molecules such as anthelmintics [8], testosterone [9], steroid hormones [10], antibacterial drugs [11], sugars [12], alditols [13], lectin [14], protein [15], and pesticides [16,17].…”

Stimuli Responsive Confinement of a Molecular Rotor Based BODIPY Dye inside a Cucurbit[7]uril Nanocavity

“…In the host−guest chemistry, it is well recognized in the literature that the prototropic dyes can undergo significant changes in their pK a values, either in the upward or in the downward directions, depending on preferential binding of either acid or base forms of the dye with the host molecule. 11,13,14,69,70 Since CB7 is an efficient cation receptor, 13,14,71 the protonated ABPH + form of the dye binds with a higher affinity with the CB7 host as compared to the neutral ABP form, as it is indicated clearly from absorption and SS fluorescence studies. Accordingly thus, similar to the other prototropic dye−CB7 systems as reported in the literature, 13,14,69 a quite large upward pK a shift was expected for the present dye−CB7 system.…”

Versatile Layer-By-Layer Highly Stable Multilayer Films: Study of the Loading and Release of FITC-Labeled Short Peptide in the Drug Delivery Field

“…A lot of research has been done in the area of multilayer films conjoining polymer and inorganic nanoparticles [14,15,16], and this can be attributed to the variable functionalities from the organic and inorganic parts of multilayer films [17,18,19,20]. The multilayer films which incorporate different inorganic parts can generally be prepared either by forming a covalent cross-link or by utilizing the non-covalent interactions between the polymer and the inorganic parts [21,22,23,24,25]. According to the literature, under ultraviolet irradiation, poly (allylamine hydrochloride) (PAH) and 4,4′-diazostilbene-2,2’-disulfonic acid disodium salt (DAS) can form covalent cross-linked layers in situ [26].…”