Versatile Layer-By-Layer Highly Stable Multilayer Films: Study of the Loading and Release of FITC-Labeled Short Peptide in the Drug Delivery Field

Nie, Kun; Yu, Xingwen; Kumar, Navnita; Zhang, Yihe

doi:10.3390/ma12081206

Cited by 5 publications

(3 citation statements)

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“…Researchers have employed LBL self-assembly for the fabrication of mesoporous silica nanoparticles and HYH–cyclodextrin films, which were constructed to load the fluorescent dyes and peptides. The release rates of these molecules were varied by the variation in the number of layers in the multilayer films [ 117 , 118 ].…”

Section: Hyh–bioceramic and Hyh–bioglass Compositesmentioning

confidence: 99%

Hyaluronic-Acid-Based Organic-Inorganic Composites for Biomedical Applications

2021

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Applications of natural hyaluronic acid (HYH) for the fabrication of organic–inorganic composites for biomedical applications are described. Such composites combine unique functional properties of HYH with functional properties of hydroxyapatite, various bioceramics, bioglass, biocements, metal nanoparticles, and quantum dots. Functional properties of advanced composite gels, scaffold materials, cements, particles, films, and coatings are described. Benefiting from the synergy of properties of HYH and inorganic components, advanced composites provide a platform for the development of new drug delivery materials. Many advanced properties of composites are attributed to the ability of HYH to promote biomineralization. Properties of HYH are a key factor for the development of colloidal and electrochemical methods for the fabrication of films and protective coatings for surface modification of biomedical implants and the development of advanced biosensors. Overcoming limitations of traditional materials, HYH is used as a biocompatible capping, dispersing, and structure-directing agent for the synthesis of functional inorganic materials and composites. Gel-forming properties of HYH enable a facile and straightforward approach to the fabrication of antimicrobial materials in different forms. Of particular interest are applications of HYH for the fabrication of biosensors. This review summarizes manufacturing strategies and mechanisms and outlines future trends in the development of functional biocomposites.

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Section: Hyh–bioceramic and Hyh–bioglass Compositesmentioning

confidence: 99%

Hyaluronic-Acid-Based Organic-Inorganic Composites for Biomedical Applications

2021

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“…A layer-by-layer (LBL) self-assembly has been widely utilized for surface modification and constructing stable multilayer films due to its simplicity, efficiency, repeatability, robustness, and flexibility. − Moreover, the thickness of multilayer films can be well-controlled down to the nanometer level. − Therefore, LBL self-assembly is considered to be an environmentally friendly manufacturing process and applied to endow large amounts of biological molecules in the membrane. Almost any type of substrate surface can be modified by LBL, including the surfaces of CLs .…”

Section: Introductionmentioning

confidence: 99%

Surface Self-Assembly Construction of Therapeutic Contact Lens with Bacterial “Kill-Releasing” and Drug-Reloading Capabilities for Efficient Bacterial Keratitis Treatment

Wen

Chen

Shen

et al. 2022

ACS Biomater. Sci. Eng.

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Bacterial keratitis, an ophthalmic emergency, can cause corneal perforation and even endophthalmitis, thus leading to severe visual impairment. To achieve effective treatment of bacterial keratitis, good bioavailability of antimicrobial drugs on the ocular surface is desired. In this investigation, a layer-by-layer (LBL) self-assembly combined with the host–guest recognition was used to construct an antibacterial coating on the surface of corneal contact lens (CLs) to improve drug bioavailability and achieve successful treatment of bacterial keratitis. First, a radical copolymerization of acrylic acid (AA) and 1-adamantan-1-ylmethyl acrylate (AdA) was carried out to synthesize a polyanionic copolymer P(AA-co-AdA) (defined as PAcA). Then, PAcA copolymer combined with poly(ethyleneimine) (PEI) was used for a layer-by-layer (LBL) self-assembly to fabricate multilayer films on the surface of CLs. An antibacterial conjugate, β-cyclodextrin–levofloxacin (β-CD-LEV), was successfully synthesized and utilized to generate antibacterial coating through a host–guest interaction between AdA and β-CD-LEV. The antibacterial ability and treatment effect of bacterial keratitis was evaluated by in vitro assay and in vivo test in an animal model of staphylococcal keratitis, demonstrating that the antibacterial coating had good antibacterial and germicidal efficacy both in vivo and in vitro. We believe that this work will provide a promising strategy for the treatment of bacterial keratitis.

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“…The papers [ 5 , 6 ] present data about multilayer films and electrospun matrices as advanced materials used in drug delivery systems. Nie et al [ 5 ] reported on the versatile layer by layer highly stable multilayer films prepared from polymer (hyaluronic acid) and inorganic–mesoporous silica nanoparticles for the delivery of FITC-labeled short peptides. The described method improves the stability of the multilayer structure by forming covalently cross-linked super strata on the outlying areas of the films.…”

mentioning

confidence: 99%