Supramolecular frameworks of binuclear dioxomolybdenum(<scp>vi</scp>) complexes with ONS donor ligands using 4,4′-azopyridine as a pillar: crystal structure, DFT calculations and biological study

Biswal, Debanjana; Pramanik, Nikhil Ranjan; Chakrabarti, Syamal; Drew, Michael G. B.; Mitra, Payel; Acharya, Krishnendu; Biswas, Sujan; Mondal, Tapan Kumar

doi:10.1039/c5nj01899d

Cited by 19 publications

(10 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results showed that derivatives of 9 were generally as active as ampicillin against bacteria strains, and most effective against P. aeruginosa and K. pneumonia, while their antifungal MIC values were in the range of 10-20 µg/mL. Figure 2) [49]. The ligands and molybdenum(VI) complexes were tested against B. cerus and L. monocytogenes (Gram-positive), E. coli and S. aureus (Gram-negative) bacteria by the disc diffusion method.…”

Section: Molybdenum Complexesmentioning

confidence: 98%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

View full text Add to dashboard Cite

Antimicrobial resistance is an increasingly serious threat to global public health that requires innovative solutions to counteract new resistance mechanisms emerging and spreading globally in infectious pathogens. Classic organic antibiotics are rapidly exhausting the structural variations available for an effective antimicrobial drug and new compounds emerging from the industrial pharmaceutical pipeline will likely have a short-term and limited impact before the pathogens can adapt. Inorganic and organometallic complexes offer the opportunity to discover and develop new active antimicrobial agents by exploiting their wide range of three-dimensional geometries and virtually infinite design possibilities that can affect their substitution kinetics, charge, lipophilicity, biological targets and modes of action. This review describes recent studies on the antimicrobial activity of transition metal complexes of groups 6–12. It focuses on the effectiveness of the metal complexes in relation to the rich structural chemical variations of the same. The aim is to provide a short vade mecum for the readers interested in the subject that can complement other reviews.

show abstract

Section: Molybdenum Complexesmentioning

confidence: 98%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

View full text Add to dashboard Cite

show abstract

“…The anti-microbial activities of Schiff-base ligand H 2 L 1 (L5) were higher than those of H 2 L 2 (L6), whereas 8 showed greater activities than 7. The Schiff-base ligand H 2 L 2 (L6) and both U VI complexes 7 and 8 showed MIC and MBC values in the range of 30 to 0.118 mg mL À 1 whereas these values for H 2 L 1 (L5) were in the range of 10 mg mL À 1 to 39 μg mL [68] Singh's group pointed out that Gram-negative bacteria possess relatively more complex cell walls compared to those of Gram-positive ones, [69] and suggested that this could be a reason why the metallic derivatives of Schiff-bases can diffuse [68] through the Gram-negative bacterial cells more efficiently than the Gram-positive ones. Several bifunctional tridentate Schiffbases and their triphenyltin(IV) and trimethyltin(IV) derivatives (structures not shown) were found to be more toxic against the Gram-positive B. subtilis than against the Gram-negative E. coli.…”

Section: Metal Complexes Exhibiting Anti-bacterial and Anti-fungal Ac...mentioning

confidence: 99%

“…The Schiff‐base ligand H 2 L 2 ( L6 ) and both U VI complexes 7 and 8 showed MIC and MBC values in the range of 30 to 0.118 mg mL −1 whereas these values for H 2 L 1 ( L5 ) were in the range of 10 mg mL −1 to 39 μg mL −1 . The Schiff‐base ligand, H 2 L L7 and their dioxomolybde‐num(VI) complexes [MoO 2 L(THF)] 9 , [MoO 2 L(1‐methimz)] 10 , [MoO 2 L(1‐allylimz)] 11 and [MoO 2 L(γ‐pic)] 12 (Figure 5) developed by Pramanik, Chakrabarti and co‐workers, showed moderate anti‐bacterial activities (MIC values in the range, 1.0–10.0 μg per disc (determined by the disc diffusion method)) against two Gram‐positive bacteria ( B. cereus , B. subtilis ), three Gram‐negative ( P. vulgaris , E. coli , P. aeruginosa ) and one yeast (fungus) ( C. albicans ) [68] …”

Section: Recent Development Of Acyclic Metal Complexes Of Schiff‐base...mentioning

confidence: 99%

“…Ligand L7 showed remarkable antioxidant activity compared to that of ascorbic acid which was even higher than the activity of complexes 9 and 102 (Figure 40). [68] Prabhakaran‘s group also studied the antioxidant activities of coumarin‐appended thiosemicarbazone ligands, L54 – L57 and their corresponding complexes, 80–83 (Figure 32) based on the DPPH free radical scavenging activities of the compounds, as well as using the phosphomolybdate method [75] . The total antioxidant activities of the compounds expressed as the number of equivalents of ascorbic acid followed the order: 82 > 81 > 80 > 83 > L56 > L55 > L54 > L57 > ascorbic acid.…”

Section: Recent Development Of Acyclic Metal Complexes Of Schiff‐base...mentioning

confidence: 99%

“…[119] showing EC 50 values (μg mL À 1 ) of ligand L7 and complexes 9 and 102 (Reproduced from Ref. [68]. Copyright (2015) RSC).…”

Section: Metal Complexes Exhibiting Antioxidant Activitiesmentioning

confidence: 99%

See 2 more Smart Citations

Recent Progress in Metal‐Incorporated Acyclic Schiff‐Base Derivatives: Biological Aspects

et al. 2022

View full text Add to dashboard Cite

Schiff-base derivatives are widely used organic compounds and their metal complexes have been drawing much attention to chemists due to interesting structural features and unique properties. The presence of nitrogen containing imine groups (À C=NÀ ) in Schiff-bases as well as in their metallic complexes and the chelating properties of these compounds are responsible for their many unique biological properties. In this review, we have summarized various acyclic Schiff-base ligands and their different metallic complexes which have been reported in the last one decade. Schiff-bases and their metal complexes have shown a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, antiinflammatory, antiviral, and antipyretic properties. We have reviewed and arranged the reported Schiff-base derivatives according to their diverse biological applications, especially their anti-bacterial and anti-fungal activities, anti-tumor and anti-cancer activities, anti-oxidant activities, anti-inflammatory activities and other therapeutic and medicinal properties. The other component of this work as a review of the molecular structures of various Schiff-bases since their molecular structures play a primary role in the biological properties. The presence of heteroatoms such as nitrogen, sulfur and oxygen with free electron pairs and aromatic rings in the structure of the Schiff-bases play significant roles in determining their properties.

show abstract

An insight into the potent antioxidant activity of a dithiocarbohydrazone appended cis‐dioxidomolybdenum (VI) complexes

Asha

Kurup

2020

Applied Organom Chemis

View full text Add to dashboard Cite

In search of antioxidants with enriched potency, the present study focus on the design and synthesis of a dithiocarbohydrazone, H3TCL derived from thiocarbohydrazide and 3‐ethoxysalicylaldehyde and its coordination complexes with molybdenum, viz, [MoO2(HTCL)D] (1–2) (where D = methanol (1), DMSO (2)) and [MoO2(HTCL)D]·DMF (where D = H2O (3)). The synthesized compounds were characterised by elemental analysis, spectroscopic techniques (FT‐IR, UV–vis and 1H‐NMR), conductivity measurements and cyclic voltammetry. Moreover the solid state structures of all the three complexes were established by single crystal X‐ray diffraction analysis as mononuclear neutral species in which the molybdenum centre assumes a distorted octahedral geometry. The dithiocarbohydrazone binds to the molybdenum centre through its phenolate oxygen, O(1), azomethine nitrogen, N(1) and thioenolate sulfur, S(1) in a dianionic tridentate mode. The assessment of intermolecular contacts in the crystal arrangement was quantified using Hirshfeld surface analysis. Further the antioxidant potential of the dithiocarbohydrazone, H3TCL and its molybdenum complexes 1–3 were evaluated using 1,1‐diphenyl‐2‐picrylhydrazyl(DPPH), 2,2′‐azinobis‐3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) and total antioxidant assays. The antioxidant activities were then compared with standard antioxidant, L‐ascorbic acid. The antioxidant potential of the synthesized compounds were then validated by molecular docking studies. Molecular modelling study was achieved to evaluate the recognition of target compound at the binding pocket of the human antioxidant enzyme, 3MNG. The docking results showed that the complexes selectively bond to the vital amino acids present in the binding pocket of the target enzyme, 3MNG.

show abstract

Supramolecular frameworks of binuclear dioxomolybdenum(vi) complexes with ONS donor ligands using 4,4′-azopyridine as a pillar: crystal structure, DFT calculations and biological study

Abstract: 4,4′-Azpy is used as linker forming pillared dioxoMo(vi) complexes first time, biological activities are reported.

Cited by 19 publications

References 86 publications

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Recent Progress in Metal‐Incorporated Acyclic Schiff‐Base Derivatives: Biological Aspects

An insight into the potent antioxidant activity of a dithiocarbohydrazone appended cis‐dioxidomolybdenum (VI) complexes

Contact Info

Product

Resources

About