Recent Progress in Metal‐Incorporated Acyclic Schiff‐Base Derivatives: Biological Aspects

Abstract

Schiff-base derivatives are widely used organic compounds and their metal complexes have been drawing much attention to chemists due to interesting structural features and unique properties. The presence of nitrogen containing imine groups (À C=NÀ ) in Schiff-bases as well as in their metallic complexes and the chelating properties of these compounds are responsible for their many unique biological properties. In this review, we have summarized various acyclic Schiff-base ligands and their different metallic complexes which have been reported in the last one decade. Schiff-bases and their metal complexes have shown a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, antiinflammatory, antiviral, and antipyretic properties. We have reviewed and arranged the reported Schiff-base derivatives according to their diverse biological applications, especially their anti-bacterial and anti-fungal activities, anti-tumor and anti-cancer activities, anti-oxidant activities, anti-inflammatory activities and other therapeutic and medicinal properties. The other component of this work as a review of the molecular structures of various Schiff-bases since their molecular structures play a primary role in the biological properties. The presence of heteroatoms such as nitrogen, sulfur and oxygen with free electron pairs and aromatic rings in the structure of the Schiff-bases play significant roles in determining their properties.

Molecular docking studies, structural analysis, biological studies, and synthesis of certain novel Schiff base from benzohydrazide derivate

“…Schiff bases have a wide range of applications in various fields, including medicine, pharmacology, and materials science, due to their diverse chemical properties and biological activities. The pharmacological properties of Schiff bases are attributed to the presence of aromatic rings with oxygen, sulfur, and nitrogen donor atoms, which contribute to their wide range of activities such as anti-inflammatory, antimalarial, antibacterial, antipyretic actions, and antifungal [3][4][5][6][7][8][9][10][11].…”

Revealing the supramolecular features of two Zn(ii) complexes derived from a new hydrazone ligand: a combined crystallographic, theoretical and antibacterial study

“…22 The interaction of these donor ligands and metal ions gives complexes of different geometries, and a literature survey reveals that these complexes have biologically active properties such as anticancer, antifungal, antibacterial, antimalarial, anti-inflammatory, antiviral, and antipyretic properties. [23][24][25] It should be noted that metal chelation can tremendously influence the antimicrobial/bioactive behavior of the organic ligands. 26 Thus, various transition metal complexes have been synthesized in this field.…”

Synthesis, Characterizations, and Quantum Chemical Investigations on Imidazo[1,2-a]pyrimidine-Schiff Base Derivative: (E)-2-Phenyl-N-(thiophen-2-ylmethylene)imidazo[1,2-a]pyrimidin-3-amine

“…Schiff bases, recognized as versatile pharmacophores, hold a prominent place among organic compounds and are extensively employed in designing and developing diverse bioactive lead compounds. − Demonstrating a diverse range of biological activities, including antifungal, , antibacterial, antimalarial, anticancer, , antiviral, antitubercular, and antidepressant properties. The nitrogen atom within the imine group, which plays a pivotal role in forming hydrogen bonds with the active sites of receptors and enzyme constituents, lends these compounds a unique capability to intervene in cellular processes. , …”

“…The nitrogen atom within the imine group, which plays a pivotal role in forming hydrogen bonds with the active sites of receptors and enzyme constituents, lends these compounds a unique capability to intervene in cellular processes. 27,28 Overall, combining Imidazo[1,2-a]pyrimidine and Schiff base in a single active pharmacophore could exhibit even more enhanced and innovative properties, thus opening new perspectives for their use in various fields. To the best of our knowledge, the literature survey reveals there have been no complete quantum chemical studies conducted on this selected moiety.…”