Supramolecular enzyme-mimicking catalysts self-assembled from peptides

Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides

“…Molecular self-assembly exhibits several similarities to natural enzymes, and peptide nanostructures can provide an enzyme-like peptidic microenvironment for the design of artificial enzymes based on organic molecules [ 238 ]. Drawing inspiration from natural enzymes, numerous peptide-based artificial enzyme mimics have been successfully created, demonstrating catalytic abilities comparable to natural enzymes, such as oxidoreductases, hydrolases, and aldolases [ 239 , 240 , 241 , 242 , 243 , 244 ]. In this context, the self-assembly of oligopeptides/amino acids with metal ions is particularly desirable for constructing nanozymes, leveraging the characteristics of non-covalent interactions [ 245 ].…”

“…Biosensors 2023, 13, 773 17 of 31 catalytic abilities comparable to natural enzymes, such as oxidoreductases, hydrolases, and aldolases [239][240][241][242][243][244]. In this context, the self-assembly of oligopeptides/amino acids with metal ions is particularly desirable for constructing nanozymes, leveraging the characteristics of non-covalent interactions [245].…”

Short Peptides for Hydrolase Supramolecular Mimicry and Their Potential Applications

“…Hydrolases are a heterogenous group of hydrolytic enzymes with diverse mechanisms used to exert catalytic activity. However, the vast majority feature one histidine (His) amino acid in the catalytic site to promote proton abstraction from water to produce the nucleophilic hydroxy-anion that can attack the substrate to hydrolyze a chemical bond (e.g., an ester, an amide, and so on, as described in Section 2 above) [ 87 ]. This His can be activated in various ways, for instance, by metal coordination in metalloproteins or by other residues constituting catalytic dyads or triads, as shown in Figure 6 for esterases as the representative example [ 23 ].…”

Bottle brush star block copolymer nanoreactors for efficient photooxidation catalysis: effects of chain softness

“…Moreover, the range of chemical reactions is narrow, industry requires more versatile catalysts. 11,12 In this turn, many researchers have shifted their focus toward synthetic macromolecules as alternative catalysts to address these challenges associated with enzyme utilization in the chemical industry. 13 Over the decades, diverse research approaches have been explored to synthesize supramolecular catalysts with biomimetic features.…”