Supramolecular dithiocarbamatogold(III) complex a potential DNA binder and antioxidant agent

Khan, Ezzat; Badshah, Amin; Tahir, Muhammad Nawaz; Altaf, Ataf Ali

doi:10.1016/j.molstruc.2013.12.023

Cited by 30 publications

(23 citation statements)

References 47 publications

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“…26 However, reaction of the corresponding ligand with CoCl 2 in 2:1 stoichiometric ratios, respectively, instead afforded tetrahedral complexes (1 and 2) where the ligands were coordinated via endocyclic-N atom in a terminal fashion. These observations are also in contrast to our previously reported results 1,23 where the same metal afforded 6-coordinated complexes (Scheme 1). The resultant structures indicate that the basicity of the three centers is widely different; therefore, coordination with cobalt ion was highly selective through endo-N.…”

Section: Chemistry and X-ray Diffractioncontrasting

confidence: 99%

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Khan¹,

Ahmad²,

Gul³

et al. 2019

Turk J Chem

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2-Aminothiazole derivatives bear three nucleophilic centers, i.e. endocyclic N, exocyclic NH 2 , and S atom in the ring system. In addition to these centers there are π-electrons in the ring system which can also expectedly be involved in some sort of coordination. To the best of our knowledge the solid state coordination chemistry of such ligands has not been fully presented in the literature. These ligands (2-amino-4-methylthiazole and 2-amino-5-methylthiazole) were coupled with CoCl 2 under aerobic conditions to form tetrahedral complexes, bis(2-amino-4methylthiazole)dichlorocobalt(II) (1) and bis(2-amino-5-methylthiazole)dichlorocobalt(II) (2). Reaction of 2-amino-5-methylthiazole with AgNO 3 led to an expected two-coordinated, bis(2-amino-5-methylthiazole)silver(I) nitrate (3) as crystalline material. In all complexes the coordination behavior of the aminothiazole derivatives was identical, coordinating to the metal center through endocyclic N atom. The structures of these complexes were confirmed by single-crystal X-ray analysis. Compounds (1-3) were screened for their antimicrobial potency against gram-negative (E. sakazkii, E. coli, K. pneumoniae) and a gram-positive bacteria (S. aurus). Additionally, their role as enzyme inhibitors (acetylcholinesterase, AChE, and butyrylcholinesterase, BChE) and their free radical scavenging ability (2,2-Diphenyl-1-picrylhydrazyl, DPPH, and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid, ABTS) were studied. These ligands bear additional nucleophilic centers (S and NH 2) and can be involved in secondary interactions as confirmed by their solid-state structures. These interactions make the molecules biologically important and thus play a pivotal role in establishing the supramolecular network. We report here the coordination chemistry and selected biological applications of complexes 1-3.

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Section: Chemistry and X-ray Diffractioncontrasting

confidence: 99%

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Khan¹,

Ahmad²,

Gul³

et al. 2019

Turk J Chem

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“…The value is calculated from the -intercept of the linear plot between 1/[DNA] (along the -axis) and 1/(1− / 0 ) (along the -axis). The found (= 4.52 × 10 4 M −1 ) is greater than that that of the literature reported similar compounds [44,45], as described in Table 2. It may be attributed to the stronger Hbonding in FcOH in comparison to others.…”

Section: Cyclic Voltameter (Cv) CV Is An Important Techniquecontrasting

confidence: 54%

Spectroscopic, Electrochemical, andIn SilicoCharacterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA

Altaf

Lal

Khan

et al. 2016

Journal of Chemistry

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We present the synthesis of 2-ferrocenylbenzoic acid (FcOH) and its electrochemical and spectroscopic characterization. FcOH was characterized for interaction with DNA using theoretical and experimental methods. UV-visible spectroscopy and cyclic voltammeter (CV) were used for the experimental account of FcOH-DNA complex. The experimental results showed that the FcOH interacts by electrostatic mode. The binding constant (Kb) and Gibbs free energy (ΔG) for the FcOH-DNA complex have been estimated as 5.3 × 104 M−1and −6.44 kcal/mol, respectively. The theoretical DNA binding of FcOH was studied with AutoDock molecular docking software. The docking studies yield good approximation with experimental data and explain the sites of binding.

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“…31 The optimum inhibitory concentration of complex 1 is impressive and it is a more efficient antioxidant than the gold-based complex reported previously. 40 On the other hand, 3b proved to be much less efficient under the same experimental conditions. Maximum percent inhibition of 18.5% could be achieved by adding a solution of 100 ppm concentration of 3b.…”

Section: Determination Of Antioxidant Activities Of Copper Complexes mentioning

confidence: 91%

Antioxidant potential and secondary reactivity of bis f diphenyl(2-pyridyl)phosphino g copper(II) complex

Khan¹,

Shahzad²,

Tahir³

et al. 2018

Turk J Chem

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Copper-based complexes with the general formulas [Cu(L) 2 ]Cl 2 (1) and [Cu 2 L 2 (µ2-L) µ2− Cl 2 ] (2) and a mixed-ligand anionic complex [Cu(L) 2 dedtc][LCl] (3b), where L = diphenyl(2-pyridyl)phosphine and dedtc = diethyldithiocarbamate, were synthesized and structurally characterized. X-ray analysis revealed that the coordination environment around the copper atom in complexes 1-3 is distorted tetrahedral. In monomeric complexes 1 and 3b both diphenyl(2-pyridyl) phosphine ligands are monodentate and are coordinated through the P-atom. In complex 3b two phosphine ligands are attached to copper through the P-atom. The third phosphine ligand acts as a bridged ligand, coordinated to the metal centers through the P-atom and N-atom. Complexes 1 and 3b were tested for radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) as a free radical. A prominent color change after mixing the solution of complex 1 and DPPH was observed, indicating the efficiency of the compound as antioxidant.

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Supramolecular dithiocarbamatogold(III) complex a potential DNA binder and antioxidant agent

Cited by 30 publications

References 47 publications

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Spectroscopic, Electrochemical, andIn SilicoCharacterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA

Antioxidant potential and secondary reactivity of bis f diphenyl(2-pyridyl)phosphino g copper(II) complex

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