Antioxidant potential and secondary reactivity of bis f diphenyl(2-pyridyl)phosphino g copper(II) complex

Khan, Ezzat; Shahzad, Adnan; Tahir, Muhammad Nawaz; Noor, Awal

doi:10.3906/kim-1803-82

Cited by 9 publications

(4 citation statements)

References 15 publications

(21 reference statements)

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“…eye. The activity of compound 1 was better than the Cu complex stabilized by phosphine ligands, as has been reported recently [25].…”

Section: Free Radical Scavenging Activities Of Complexes 1-4supporting

confidence: 80%

“…The activity of compounds 2-4 were the least, and color change was difficult to be observed with the naked eye. The activity of compound 1 was better than the Cu complex stabilized by phosphine ligands, as has been reported recently [25]. eye.…”

Section: Free Radical Scavenging Activities Of Complexes 1-4supporting

confidence: 77%

“…Recently, we reported Cu complexes stabilized by monodentate non-thiourea ligands bearing coordination numbers (CN) four [24,25] and six [26,27], where steric bulk and/or M-X fragment (X = halogen, AcO) played a vital role in coordination around the metal ion. These complexes with thiourea ligands [28,29] showed better biological activities.…”

Section: Introductionmentioning

confidence: 99%

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Complexes of 1,3-Diisobutyl Thiourea with Copper(I), Zinc(II) and Mercury(II): Their Antioxidant and Antibacterial Evaluation

et al. 2021

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The reaction of 1,3-Diisobutyl thiourea (Tu) with metal salts, {[CuX (X = Cl, I)], [ZnCl2] and [HgI2] in an appropriate stoichiometric ratio afforded the corresponding metal complexes [Tu2CuCl] (1), [Tu3CuI] (2), [Tu2ZnCl2] (3) and [Tu2HgI2] (4) in good yields. The FT-IR data show typically broad signals (3278–3288 cm−1) attributed to the involvement of NH bonds in extensive hydrogen bonding. The structures of complexes were proposed based on a spectroscopic data set. Compounds 1 and 2 were additionally characterized by single-crystal X-ray analysis. Complexes 1–4 were tested for their free radical scavenging efficiency using 2,2-diphenyl-1-picrylhydrazyl free radical (hereafter abbreviated as DPPH). The free radical scavenging activity was a function of decrease in the resultant absorption of DPPH solution after the mixing of an appropriate concentration of the respective complex. The activity of complexes was determined to be dose dependent and increased concentration of the complex resulted in improved antioxidant activity. Compound 1 was found to be the most efficient, with 79.9% free radical scavenging activity. Complexes were also tested for their efficiency against selected strains of bacteria (E. coli, S. flexneri, S. typhi, and P. aeruginosa) and the activities were compared to commercially available standard drug cephradine. Compound 1 was more active against P.aeruginosa (ZI 13.25), while compound 4 was found to be more active against E. coli (ZI 11.0), S. flexneri (ZI 11.2), and S. typhi (ZI 10.5).

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“…eye. The activity of compound 1 was better than the Cu complex stabilized by phosphine ligands, as has been reported recently [25].…”

Section: Free Radical Scavenging Activities Of Complexes 1-4supporting

confidence: 80%

Section: Free Radical Scavenging Activities Of Complexes 1-4supporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Complexes of 1,3-Diisobutyl Thiourea with Copper(I), Zinc(II) and Mercury(II): Their Antioxidant and Antibacterial Evaluation

et al. 2021

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“…Percentages of radical scavenging activities for complexes 1, 2 are summarized in Table 3 and the same results are graphically represented in Figures 5 and 6, which shows similar gradation in a dose dependent manner as we have reported recently. 43 It is evident from the table above that the sample solutions show significant antioxidant activities by showing considerable decrease in absorbance at 517 or 734 nm with increasing concentration of the respective compound. Although complexes 1 and 2 are structurally very close, their activity is quite different from each other.…”

Section: Dpph and Abts Free Radical Scavenging Activity Of The Synthementioning

confidence: 95%

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Khan¹,

Ahmad²,

Gul³

et al. 2019

Turk J Chem

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2-Aminothiazole derivatives bear three nucleophilic centers, i.e. endocyclic N, exocyclic NH 2 , and S atom in the ring system. In addition to these centers there are π-electrons in the ring system which can also expectedly be involved in some sort of coordination. To the best of our knowledge the solid state coordination chemistry of such ligands has not been fully presented in the literature. These ligands (2-amino-4-methylthiazole and 2-amino-5-methylthiazole) were coupled with CoCl 2 under aerobic conditions to form tetrahedral complexes, bis(2-amino-4methylthiazole)dichlorocobalt(II) (1) and bis(2-amino-5-methylthiazole)dichlorocobalt(II) (2). Reaction of 2-amino-5-methylthiazole with AgNO 3 led to an expected two-coordinated, bis(2-amino-5-methylthiazole)silver(I) nitrate (3) as crystalline material. In all complexes the coordination behavior of the aminothiazole derivatives was identical, coordinating to the metal center through endocyclic N atom. The structures of these complexes were confirmed by single-crystal X-ray analysis. Compounds (1-3) were screened for their antimicrobial potency against gram-negative (E. sakazkii, E. coli, K. pneumoniae) and a gram-positive bacteria (S. aurus). Additionally, their role as enzyme inhibitors (acetylcholinesterase, AChE, and butyrylcholinesterase, BChE) and their free radical scavenging ability (2,2-Diphenyl-1-picrylhydrazyl, DPPH, and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid, ABTS) were studied. These ligands bear additional nucleophilic centers (S and NH 2) and can be involved in secondary interactions as confirmed by their solid-state structures. These interactions make the molecules biologically important and thus play a pivotal role in establishing the supramolecular network. We report here the coordination chemistry and selected biological applications of complexes 1-3.

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Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

Khan

2021

ChemistrySelect

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Pyridine (py) is an important heterocyclic compound and is an integral part of various natural products. There are various medicines containing py ring system being available in the market to combat different human ailments. Observing the medicine market, Omeprazole, a widely used py-based drug in medicinal market since 1998. Netupitant (an antiemitic drug, since 2014) is used in combination with another drug to prevent acute and delayed vomiting and nausea associated with cancer chemotherapy led the run towards development of anticancer drugs. Several drugs have been approved by FDA for the treatment of cancer in recent years such as, Abemaciclib (2015), Lorlatinib (2018), Apalutamide (2018) and Ivosidenib (2019). Research on py on the bases of these advancements is an evergreen field and associated with greater hopes to address several disease related issues. Several compounds are in the process of clinical trials and are expected to serve various purposes in days to come. This review article deals with recent findings in py chemistry and its coordination complexes. The medicinal efficiency has been argued for organic and inorganic derivatives. Selected biological applications are hereby discussed as follow up study of our report in 2015. Suitable literature prior to 2015 has also been incorporated in appropriate places in order to cover the scope in broader sense.

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Antioxidant potential and secondary reactivity of bis f diphenyl(2-pyridyl)phosphino g copper(II) complex

Cited by 9 publications

References 15 publications

Complexes of 1,3-Diisobutyl Thiourea with Copper(I), Zinc(II) and Mercury(II): Their Antioxidant and Antibacterial Evaluation

Complexes of 1,3-Diisobutyl Thiourea with Copper(I), Zinc(II) and Mercury(II): Their Antioxidant and Antibacterial Evaluation

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

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