Complexes of 1,3-Diisobutyl Thiourea with Copper(I), Zinc(II) and Mercury(II): Their Antioxidant and Antibacterial Evaluation

Abstract

The reaction of 1,3-Diisobutyl thiourea (Tu) with metal salts, {[CuX (X = Cl, I)], [ZnCl2] and [HgI2] in an appropriate stoichiometric ratio afforded the corresponding metal complexes [Tu2CuCl] (1), [Tu3CuI] (2), [Tu2ZnCl2] (3) and [Tu2HgI2] (4) in good yields. The FT-IR data show typically broad signals (3278–3288 cm−1) attributed to the involvement of NH bonds in extensive hydrogen bonding. The structures of complexes were proposed based on a spectroscopic data set. Compounds 1 and 2 were additionally characterized by single-crystal X-ray analysis. Complexes 1–4 were tested for their free radical scavenging efficiency using 2,2-diphenyl-1-picrylhydrazyl free radical (hereafter abbreviated as DPPH). The free radical scavenging activity was a function of decrease in the resultant absorption of DPPH solution after the mixing of an appropriate concentration of the respective complex. The activity of complexes was determined to be dose dependent and increased concentration of the complex resulted in improved antioxidant activity. Compound 1 was found to be the most efficient, with 79.9% free radical scavenging activity. Complexes were also tested for their efficiency against selected strains of bacteria (E. coli, S. flexneri, S. typhi, and P. aeruginosa) and the activities were compared to commercially available standard drug cephradine. Compound 1 was more active against P.aeruginosa (ZI 13.25), while compound 4 was found to be more active against E. coli (ZI 11.0), S. flexneri (ZI 11.2), and S. typhi (ZI 10.5).

Syntheses and structural characterization of divalent metal complexes (Co, Ni, Pd and Zn) of sterically hindered thiourea ligand and a theoretical insight of their interaction with SARS-CoV-2 enzyme

“…Such hydrogen bonds as well as secondary interactions play a vital role in biological systems and compounds having such short contacts have been found to be better biologically active candidates [20] . Coordination compounds and their biological applications are of particular importance to us [21] , [22] , [23] , [24] . Specifically, there has been a growing demand of metal-based compounds due to their bioinorganic applications.…”

Mononuclear Tricoordinate Copper(I) and Silver(I) Halide Complexes of a Sterically Bulky Thiourea Ligand and a Computational Insight of Their Interaction with Human Insulin

“…The ability of thiourea to form hydrogen bonds favorably affects the solubility of its complexes in an aqueous medium, which contributes to better penetration into cells [25]. In this context, biological applications of coordination compounds are of particular importance to us [26][27][28][29]. Thiourea derivatives and their transition metal complexes have been shown to be quite potent antidiabetic agents [30][31][32].…”

Synthesis, characterisation and biological activities of mixed ligand oxovanadium (IV) complexes derived from N,N‐diethyl‐N′‐para‐substituted‐benzoylthiourea and hydrotris(3,5‐dimethylpyrazolyl)borate

“…[11][12][13][14] The chemistry of benzoylthiourea compound and its transition metal complexes has attracted interest due to their prospective use in a wide range of applications. Previous studies showed that benzoylthiourea complexes have antimicrobial, [15][16][17][18][19][20][21][22][23] antitumor [24][25][26][27][28] antioxidant, [24,29] cytotoxic [30] and insecticidal [31,32] properties. From a chemistry point of view, a notable feature of benzoylthiourea derivatives is due to its strong donor groups (carbonyl and thioamide), which make them very attractive for a coordination agent.…”