Supramolecular Assembly between Polystyrene-block-Poly(4-vinylpyridine) and 4-Dodecylbenzenesulfonic Acid

Hong, Jian-Yu; Hong, Jin‐Long

doi:10.1023/b:jpol.0000031074.94735.74

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…In addition, the absorption of the OH group shows a shift to a slightly lower wave number of 3370 cm −1 , when complexation occurs between PCL-b-P4VP and α-CD. This suggests that the OH group in the α-CD has a preferential interaction with the PCL-b-P4VP, owing to the formation of inter-molecular hydrogen bonds [19]. The shifts in the absorption frequency of the OH bonds in the two ICs are nearly identical (~20 cm −1 ).…”

Section: Resultsmentioning

confidence: 91%

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

Chuang

Prasannan³

et al. 2015

J Polym Res

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A novel method has been used to prepare the selfassembled supramolecular micelles which aid in the delivery of anticancer drugs. α-Cyclodextrin (α-CD) induces a micellization process of poly(ε-caprolactone-block-4-vinylpyridine) (PCL-b-P4VP) copolymers through selective inclusion of PCL segments into the cavity of α-CD, resulting in the formation of pseudopolyrotaxane-b-P4VP. Compound pseudopolyrotaxane-b-P4VP forms supramolecular micelles in aqueous medium through self-assembly, which has been characterized using various analytical techniques. The resultant complex micelles consist of pseudopolyrotaxane as the core and P4VP chains in the outer shell, and the micelles possess a well-defined spherical morphology. The selfassembly process can easily be tailor-made by varying the number of PCL and P4VP segments in the PCL x -b-P4VP y copolymer. The arrangement of pseudopolyrotaxane-b-P4VP in the form of Bchannel-type^crystallites (derived from the supramolecular columns) is confirmed from the wide-angle X-ray diffraction (WAXD) patterns as well as by the composition of the inclusion complexes (ICs) calculated via proton nuclear magnetic resonance ( 1 H NMR) spectral data. The biocompatibility of the micelles was evaluated by a cell viability test and the results revealed excellent cytocompatibility. The prepared micelles were used as carriers for the model anticancer drug doxorubicin (DOX) and successful drug release was observed with a loading content of 14.4 % (w/w) and a loading efficiency of 28.9 %. In vitro drug delivery was evaluated in phosphate-buffered saline (PBS) solution. DOX release from the micelles was considerably faster at pH 5.0 in comparison to a physiological pH of 7.4. The development of supramolecular self-assembled micelles based on partial IC formation between α-CD and compatible block copolymers opens a new, facile and attractive approach for designing novel drug carriers for future pharmaceutical applications.

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Section: Resultsmentioning

confidence: 91%

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

Chuang

Prasannan³

et al. 2015

J Polym Res

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“…Recently, a strategy that combines supramolecular chemistry with block copolymer self-assembly has been developed and provides a simple and powerful technique for controlling the formation of well-defined nanostructures in bulk − and in thin films. − In this approach, low molar mass substances are associated with one of the blocks by noncovalent interactions. Most frequently to date, small molecules bearing hydroxy and/or carboxylic acid functions have been hydrogen-bonded to pyridine functions in poly(styrene- b -4-vinylpyridine) (PS4VP) block copolymers.…”

Section: Introductionmentioning

confidence: 99%

A Study of the Supramolecular Approach in Controlling Diblock Copolymer Nanopatterning and Nanoporosity on Surfaces

2006

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Thin films of poly(styrene-b-4-vinylpyridine) (PS4VP) [M n(PS) = 71.9 kg/mol; M n(P4VP) = 30.2 kg/mol] mixed with 1,5-dihydroxynaphthalene (DHN) were dip-coated onto flat substrates from THF solutions. The resultant nanostructures were characterized by AFM, TEM, infrared spectroscopy, contact angle measurements, and cyclic voltammetry. The DHN selectively enriches the P4VP domains through hydrogen bond complexation, giving relative block compositions that should result in lamellar morphology in the bulk. However, films dip-coated from solutions of variable DHN:4VP molar ratios self-assemble into a quasi-hexagonal array of nodules of P4VP + DHN protruding above a PS matrix. This morphology can be ascribed, at least in part, to greater solubility in THF of PS compared to P4VP. The solubility difference appears to be highest for equimolar DHN:4VP. The removal of DHN from the deposited films by rinsing with methanol creates regularly patterned nanoporous films. The geometric parameters of the nanopatterns before and after DHN removal depend on the DHN:4VP ratio. Electrochemical measurements indicate that the pores penetrate the methanol-rinsed films most deeply for those prepared using an initial DHN:4VP molar ratio of 4:1. It was estimated from these measurements that a P4VP layer of about 2 nm thick is located at the film−substrate interface, through which electron tunneling can occur.

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“…4a, the DBSA main bands are located at 1345, 1166, 894, 832 and 569 cm −1 . 40,41 In particular, the band at 832 cm −1 is characteristic of para -substituted benzenes 40 and it is also found in the PEDOT:DBS spectrum, together with the band located at 1345 cm −1 , which corresponds to the S–O stretching of the SO 3 group in DBS. Besides, these bands are also present in the IR spectra of PEDOT:DBS–Fe 3 O 4 composites (Fig.…”

Section: Resultsmentioning

confidence: 90%

Tuning the electrical and magnetic properties in multifunctional composite materials based on the PEDOT:DBS conducting polymer and magnetite nanoparticles

et al. 2022

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Supramolecular Assembly between Polystyrene-block-Poly(4-vinylpyridine) and 4-Dodecylbenzenesulfonic Acid

Cited by 7 publications

References 14 publications

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

A Study of the Supramolecular Approach in Controlling Diblock Copolymer Nanopatterning and Nanoporosity on Surfaces

Tuning the electrical and magnetic properties in multifunctional composite materials based on the PEDOT:DBS conducting polymer and magnetite nanoparticles

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