Supraclavicular lymph node as the first presentation and late skin metastasis: an unusual clinical course for prostate cancer

Çulpan, Meftun; Yıldırım, Asıf; Turan, Turgay; Çaşkurlu, Turhan

doi:10.5152/tud.2017.29660

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…Prostate cancer metastasis to the supraclavicular lymph nodes is regarded as extensive case of systemic disease and poor prognosis with mean survival of 19.8 and 29.7 months. [6,13] However, cases with long remission of disease after ADT who are clinically and biochemically quiescent have been reported. [13,17,18] A case report of a patient with cervical lymphadenopathy being symptom free for 9 years had been reported.…”

Section: Discussionmentioning

confidence: 99%

“…[5] Common sites for metastasis of prostate cancer include local lymph nodes, bones, and lungs. [5,6] Lymphatic metastasis is most often to the obturator, common iliac, the presacral, and the para-aortic lymph nodes. [6,7] Occasionally, metastasis to the supraclavicular lymph nodes has been documented, and rarely, this supraclavicular lymphadenopathy may be the initial clinical presentation of the patient [6,7] with a reported incidence rate of 0.28% and 0.36% for supraclavicular lymph node and cutaneous metastasis, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…[6,7] Occasionally, metastasis to the supraclavicular lymph nodes has been documented, and rarely, this supraclavicular lymphadenopathy may be the initial clinical presentation of the patient [6,7] with a reported incidence rate of 0.28% and 0.36% for supraclavicular lymph node and cutaneous metastasis, respectively. [6] Eight cases of scalp metastasis have been reported in literature. [2] Below is a case of a prostate cancer patient who presented simultaneously with the left supraclavicular and scalp masses and his management.…”

Section: Introductionmentioning

confidence: 99%

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Cancer of the Prostate Presenting as Scalp and Left Supraclavicular Masses

Odoemene¹

2019

Clinic Res Urol

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Prostate cancer (PCa) is one of the most fatal cancers and the second most common cancer in men worldwide. The incidence and prevalence vary in different parts of the world. In Nigeria, it is the most common cancer in men with low awareness and majority of the patients presenting with advanced disease. Rarely, this advanced disease may present clinically as supraclavicular lymphadenopathy. This is a case of a 72-year-old man who presented simultaneously with the left supraclavicular and left parietal scalp masses. The serum prostate-specific antigen was 416 ng/ml. A hard prostate was felt on digital rectal examination. Prostatic biopsy showed adenocarcinoma of the prostate. The patient had surgical castration after which both the left supraclavicular and scalp masses regressed within 10 days. There is need to entertain prostate cancer as a differential diagnosis in any middle-aged and elderly man presenting with supraclavicular and scalp masses.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cancer of the Prostate Presenting as Scalp and Left Supraclavicular Masses

Odoemene¹

2019

Clinic Res Urol

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“…Metastasis of infradiaphragmatic tumors to the left supraclavicular lymph node is also reported to be rare. The incidence of metastasis has been reported to be 3.6% for intrahepatic cholangiocarcinoma [ 1 ], 1.4% for bladder carcinoma [ 5 ], and approximately 0.3% for prostate carcinoma [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Left supraclavicular (Virchow’s) node metastasis detected before primary infradiaphragmatic tumor: a case series

et al. 2022

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Background Metastasis of infradiaphragmatic tumors to the left supraclavicular lymph node is reported to be rare. When metastasis is detected in the left supraclavicular node in patients with head and neck carcinoma, locating the primary cancer remains a difficult and time-consuming challenge despite the dramatic development of screening technologies and treatment methods. Case presentation We report three cases of malignant infradiaphragmatic tumor diagnosed following an initial finding of left supraclavicular node metastasis after surgery for tongue squamous cell carcinoma (follow-up period, range 18–62 months). In these cases, adenocarcinoma was diagnosed based on left supraclavicular node biopsies, and a second primary tumor was found, in a 78-year-old Japanese woman with a diagnosis of cholangiocarcinoma, a 64-year-old Japanese man with a diagnosis of bladder carcinoma, and a 61-year-old Japanese man with a diagnosis of prostate carcinoma. In the cholangiocarcinoma case, carbohydrate antigen 19-9 and alpha-fetoprotein levels helped to diagnose cholangiocarcinoma. Palliative care only was given, with survival for 11 months after diagnosis of lymph node metastasis. In the bladder carcinoma case, pathological analysis of fine-needle aspiration biopsy specimen of the metastatic cervical lymph node showed atypical cells with slight squamous differentiation. Hematoxylin–eosin staining of the bladder lesion did not identify a clear glandular or squamous component, and we could not make a definitive diagnosis of whether the lesion was poorly differentiated squamous cell carcinoma, adenocarcinoma, or high-grade urothelial carcinoma. GATA3 staining aided in the diagnosis of urothelial bladder cancer with left supraclavicular node metastasis. He survived for 2 months after diagnosis of left supraclavicular lymph node metastasis. In the prostate carcinoma case, 18F‐fluorodeoxyglucose uptake was weak. Prostate-specific antigen levels and magnetic resonance imaging findings aided the diagnostic process. This patient underwent bilateral orchiectomy and adjuvant hormonal therapy and survived for 47 months after diagnosis of left supraclavicular node metastasis. Conclusions Pathological diagnosis on the basis of immunohistochemistry and specific diagnosis methods such as radiological and serological assessments are important for providing rapid diagnosis and appropriate treatment.

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Virchow’s node as the initial presentation of metastatic prostate cancer: a case series of a common cancer in uncommon location

Mbwambo

Mremi

Mbwambo

et al. 2020

Journal of Surgical Case Reports

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Prostate cancer is one of the commonest cancers among men contributing significantly to the overall cancer burden globally. Most patients present with lower urinary tract symptoms. Metastasis to supraclavicular lymph nodes is unusual presentation, which has been rarely reported particularly as the primary presentation. We report two rare cases of advanced prostatic adenocarcinoma presenting with firm, non-tender lump in the left supraclavicular region between the two heads of the sternocleidomastoid muscle, (that is Virchow’s node) as initial primary symptom. Examination of the patients revealed an elevated prostatic-specific antigen (PSA) of > 100 ng/ml levels, and the diagnosis was confirmed by histological evaluation and immunostaining with PSA of the supraclavicular lymph nodes and prostate biopsies. This case series emphasizes the importance of considering prostate cancer in the differential diagnosis of male patients with supraclavicular lymphadenopathy.

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Supraclavicular lymph node as the first presentation and late skin metastasis: an unusual clinical course for prostate cancer

Cited by 3 publications

References 14 publications

Cancer of the Prostate Presenting as Scalp and Left Supraclavicular Masses

Cancer of the Prostate Presenting as Scalp and Left Supraclavicular Masses

Left supraclavicular (Virchow’s) node metastasis detected before primary infradiaphragmatic tumor: a case series

Virchow’s node as the initial presentation of metastatic prostate cancer: a case series of a common cancer in uncommon location

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