Supraclavicular Brachial Plexus Block: A Comparative Clinical Study between Bupivacaine and Levobupivacaine

Pedro, José Ricardo Pinotti; Mathias, L; Gozzani, Judymara Lauzi; Pedro, Flavia Salles de Souza Pinotti; Rittes, José Carlos

doi:10.1016/s0034-7094(09)70091-1

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…Our findings were different from those of Jose Ricardo et al who reported that there was no statistically significant difference in the latency of motor blockade. [10] Our findings were consistent with Cenk Ilham et al who found that the motor block onset was statistically faster in group B (5.07+/-4.07 min) than group L (9.2+/-7.9 min). [9] Their findings were statistically significant.…”

Section: Section: Anaesthesiasupporting

confidence: 93%

“…However Jose Ricardo, et al found that there was earlier sensory block onset with levobupivacaine 0.5% as compared with bupivacaine 0.5% (p<0.05). [10] Faster onset of sensory block in levobupivacaine group was also found in the studies done by Fusun et al, [11] H.Evren et al, [12] Jyoti P Deshpande et al [13] In the study done by Fusun and colleagues, [11] the patients were randomly allocated in two groups, group B (n=20) received 40 ml 0.375% bupivacaine + 2 mg morphine and group L (n=15) received 40 ml 0.375% levobupivacaine + 2 mg morphine. They found that the onset of sensory block was earlier with group L ( 9.66+/-2.52 ) than group B ( 13.40+/-2.76 ) which was statistically significant (p<0.0001).…”

Section: Section: Anaesthesiamentioning

confidence: 99%

“…[17] This was found to be statistically non significant. In the studies done by C.R.Cox, [16] Jose Ricardo, [10] Fusun, [11] Dr Charu J Pandya, [14] Hetal Rathod, [18] no statistically significant difference was observed in the hemodynamic parameters. Among the patients, 5 (16.7%) patients in group B had tourniquet pain while 3(10.0%) patients in group L had tourniquet discomfort.…”

Section: Section: Anaesthesiamentioning

confidence: 99%

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Supraclavicular Brachial Plexus Block: A Comparative Clinical Study between Bupivacaine and Levobupivacaine

Jewalikar¹,

Waheed²

2017

AIMDR

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Background: Supraclavicular brachial plexus block is an excellent regional anaesthesia technique for upper extremity surgery. Bupivacaine is most commonly used local anaesthetic in peripheral nerve blocks. The cardiotoxicity of bupivacaine limits its use in large volumes necessitating the need for alternative drugs in upper extremity blocks. Levobupivacaine is a promising drug with less cardiodepressor activity. The basis for this study is to compare its sensory and motor blockade with that of bupivacaine. Methods: This study included 60 ASA grade | and || patients of both sex aged 18 years and above, weighing between 50-70 kg undergoing upper limb orthopaedic surgery. They were randomly allocated to group B (received 30 ml 0.5% bupivacaine) and group L (received 30 ml 0.5% levobupivacaine). Comparison was made regarding onset, duration and quality of sensory and motor blockade between the two groups. Results: Statistically significant difference was found in the onset of sensory and motor blockade between the two drugs with short latency in-group B. Conclusion: Levobupivacaine proves to be a comparable and better alternative to bupivacaine in supraclavicular brachial plexus block owing to its cardiostability.

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Section: Section: Anaesthesiasupporting

confidence: 93%

Section: Section: Anaesthesiamentioning

confidence: 99%

Section: Section: Anaesthesiamentioning

confidence: 99%

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Supraclavicular Brachial Plexus Block: A Comparative Clinical Study between Bupivacaine and Levobupivacaine

Jewalikar¹,

Waheed²

2017

AIMDR

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“…Pedro et al (16) determined that sensorial block onset time was approximately 9 min in a supraclavicular brachial plexus block established with 30 mL of 0.5 % bupivacaine. The results found in that study are compatible with the results of our study.…”

Section: Discussionmentioning

confidence: 99%

The effect of addition of lidocaine to bupivacaine on anesthesia beginning time, block time, and block quality in lateral sagittal infraclavicular block

Özmen¹,

Alici²,

Çelik³

et al. 2013

Turk J Med Sci

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A mesoporous MCM-41 molecular sieve material with a molar ratio of SiO 2 /Al 2 O 3 = 70 and loaded with H 3 PO 4 was used as a catalyst for the alkylation of toluene, using various alcohols, namely methanol, iso-propanol, and tert -butanol, as alkylating agents. Para-alkylated toluene was the predominant product, formation of which was enhanced by moderate temperature, low amounts of the alkylating agents in the feed, and high carrier gas flow rate. Time on stream was found to exert a profound effect on the selectivity and conversion to the different products.

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“…Both bupivacaine and levobupivacaine (both the L‐form and the S enantiomer of bupivacaine) are local anaesthetics routinely used in anaesthesia practice . Bupivacaine is more cardiotoxic than levobupivacaine . The toxicity was attributed to its high affinity to the myocardial Na + channel .…”

mentioning

confidence: 99%

The Effect of Intraspinal Bupivacaine versus Levobupivacaine on the QTc Intervals during Caesarean Section: A Randomized, Double‐blind, Prospective Study

Doğan

Yıldız

Akçay

et al. 2013

Basic Clin Pharma Tox

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The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivacaine group) or levobupivacaine (the levobupivacaine group). ECG recordings were performed prior to spinal anaesthesia at baseline (T1), 5 min. after spinal anaesthesia, but before uterine incision (T2), and after skin closure (T3). QT intervals were calculated and corrected with the patients' heart rate according to the Bazett formula. Compared with baseline values, mean maximum QTc intervals at T2 and T3 were significantly longer in the levobupivacaine group, but only at T2 in the bupivacaine group. In addition, compared with the bupivacaine group, the QTc maximum interval at T3 was significantly longer in the levobupivacaine group. At T2, the QTc maximum intervals were longer than baseline in both groups. By the end of the surgery, the prolongation of the QTc interval had disappeared in the bupivacaine group but not in the levobupivacaine group.The QT interval is defined as the measurement of time between the start of the Q wave and the end of the T wave in the heart's electrical cycle. The QT interval represents the total period of the left ventricle's depolarization and its repolarization. QT prolongation is associated with increased risk of ventricular arrhythmias, leading to polymorphic ventricular tachycardia (Torsades de Pointes) and ventricular fibrillation [1]. The myocardial conduction changes (prolongation of PQ or QT intervals or QRS widening) are assumed to be early signs of drug-related cardiac toxicity and might be determined even in the absence of any significant changing in contractility [2]. Prolongation of the QT interval can be either hereditary or acquired. It is associated with different medications, as well as cardiac, neurological and electrolyte disorders. Several cardiac and non-cardiac medications, including anaesthetics [3], can also interfere with cardiac repolarization and prolong the QT interval, and sometimes may cause drug-induced Torsades de Pointes and even sudden cardiac death [4][5][6][7].Spinal anaesthesia is commonly used in emergency and elective caesarean section because it provides rapid and adequate anaesthesia. Regional anaesthesia techniques eliminate the increased catecholamine levels that result from laryngoscopy and intubation. Increased plasma catecholamine concentrations and sympathetic activity are related with increased incidence of ventricular arrhythmias and even sudden death because of prolonged QT interval [8,9]. In addition, regional techniques eliminate or decrease the need for induction agents, volatile anaesthetics, opioids, muscle relaxants and neuromuscular reversal intra-operatively and postoperatively, all of which have variable effects on QT intervals [5,10,11]. Both bupivacaine and levobupivacaine (both the L-form and the S ...

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Supraclavicular Brachial Plexus Block: A Comparative Clinical Study between Bupivacaine and Levobupivacaine

Abstract: The anesthetic efficacy of levobupivacaine in brachial plexus block was similar to that of the racemic solution commonly used.

Cited by 7 publications

References 22 publications

Supraclavicular Brachial Plexus Block: A Comparative Clinical Study between Bupivacaine and Levobupivacaine

Supraclavicular Brachial Plexus Block: A Comparative Clinical Study between Bupivacaine and Levobupivacaine

The effect of addition of lidocaine to bupivacaine on anesthesia beginning time, block time, and block quality in lateral sagittal infraclavicular block

The Effect of Intraspinal Bupivacaine versus Levobupivacaine on the QTc Intervals during Caesarean Section: A Randomized, Double‐blind, Prospective Study

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