Suppurative, Nonseptic Polyarthropathy in Dogs

Abstract

The goals of this study were to determine the historical, physical examination, and clinicopathologic findings in dogs with suppurative, nonseptic polyarthropathy and to identify concurrent disorders associated with this syndrome. Medical records of 52 dogs with cytologic evidence of suppurative inflammation in two or more joints were examined retrospectively. Age of dogs was 4.8 years (median, range: 0.5-12 years). There was no clear breed or sex predilection, but most were large-breed dogs (body weight > or = 20 kg [44.4 lbs] in 40/52). Body temperature was 103.0 degrees F (39.4 degrees C) (median, range: 100.0-105.9 degrees F), with 29 of 52 dogs having a body temperature > or = 103 degrees F (39.4 degrees C). Lameness was identified in 42 of 52 dogs. Erosive changes were found in only 1 of 37 dogs that had radiography performed. A clear underlying disease process was not identified in 34 of 52 dogs. Seven dogs had evidence of infectious or inflammatory processes at extra-articular sites; 4 dogs were diagnosed with systemic lupus erythematosus (SLE); 2 dogs had gastrointestinal disease; 2 dogs had been vaccinated within 1 month before onset of polyarthritis; 1 dog had cancer; 1 dog had polyarthritis and meningitis; and 1 dog had erosive polyarthritis. Of the 44 dogs tested, 25 had antibodies to Borrelia burgdorferi, detected by an ELISA assay, which was significantly greater than the general hospital population (P = .007). Antibodies against Rickettsia rickettsiae and Ehrlichia canis were not definitively identified in the sera of any dog tested in this study (45 and 44 dogs, respectively). We conclude that an underlying disease process is not identified in most cases of suppurative polyarthropathy in dogs and that intestinal disease, neoplasia, and SLE are uncommon causes of polyarthritis. While seropositivity against the causative agent of Lyme disease was common and possibly a cause of polyarthritis in some dogs of our study, evidence of other vector-borne infection was not identified.

Poliartrite em cães - 27 casos (2007-2013)

“…Com base nestes critérios, PA erosiva não foi identificado em nenhum dos cães deste estudo, sugerindo que a PA não erosiva é a mais frequente. Em outro estudo de PA (sépticas e não sépticas) em cães, alterações erosivas foram observadas em 3% dos casos que tinham radiografias das articulações (RONDEAU et al, 2005).…”

“…Para JACQUES et al (2002), RONDEAU et al (2005) e STULL et al (2008, as PA comumente relatadas são imunomediadas (idiopática), entretanto, podem ter uma falsa representação, devido à dificuldade em estabelecer a etiologia. No presente estudo, não foi possível classificar as PA quanto à etiologia, devido a não realização dos exames complementares necessários para exclusão dos diagnósticos diferenciais.…”

“…Em cães, essa afecção é considerada pouco frequente e quase sempre de origem infecciosa ou imunomediada e raramente induzida por cristais (JACQUES et al, 2002;RONDEAU et al, 2005;GOLDSTEIN, 2010;WILSON-WAMBOLDT, 2011;JOHNSON & MACKIN, 2012a). Poliartrites infecciosas podem ser causadas por vírus, bactérias, protozoários (SPRENG, 1993;MCCONKEY et al, 2002;SANTOS et al, 2006), ou fungos (RONDEAU et al, 2005;GOLDSTEIN, 2010;WILSON-WAMBOLDT, 2011).…”

“…Em cães, essa afecção é considerada pouco frequente e quase sempre de origem infecciosa ou imunomediada e raramente induzida por cristais (JACQUES et al, 2002;RONDEAU et al, 2005;GOLDSTEIN, 2010;WILSON-WAMBOLDT, 2011;JOHNSON & MACKIN, 2012a). Poliartrites infecciosas podem ser causadas por vírus, bactérias, protozoários (SPRENG, 1993;MCCONKEY et al, 2002;SANTOS et al, 2006), ou fungos (RONDEAU et al, 2005;GOLDSTEIN, 2010;WILSON-WAMBOLDT, 2011). As artrites induzidas por cristal são ocasionadas pela deposição de cristais de urato de sódio (gota) ou de pirofosfato de cálcio di-hidratado (pseudogota) (THOREN-TOLLING & RYDEN, 1991;DE HAAN & ANDREASEN, 1992;HOPPER, 1993;GOLDSTEIN, 2010) e as de etiologia imunomediada são decorrentes de um estímulo imunológico que desencadeia a formação e a deposição de imunocomplexos e liberação de enzimas lisossomais no interior da membrana sinovial (hipersensibilidade do tipo III) (HOPPER, 1993;JACQUES et al, 2002;GOLDSTEIN, 2010).…”

“…Alguns estudos sobre poliartrite são encontrados na literatura, basicamente internacional (JACQUES et al, 2002;WEBB et al, 2002;CLEMENTS et al, 2004;RONDEAU et al, 2005;STULL et al, 2008), e na forma de relatos de casos (THILAGAR et al, 1990;WOODARD et al, 1991;SPRENG, 1993;MCCONKEY et al, 2002;SANTOS et al, 2006;WILSON-WAMBOLDT, 2011). Na literatura nacional, no entanto, poucos dados e estudos retrospectivos são obtidos sobre o assunto.…”