Suppressor T cells: some answers but more questions

Dorf, Martin E.; Kuchroo, Vijay K.; Collins, Mary

doi:10.1016/0167-5699(92)90002-o

Cited by 52 publications

(28 citation statements)

References 23 publications

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“…The idea that CD8 ϩ T cells are capable of suppressing immune responses first emerged when it was found that adoptive transfer of T cells from mice tolerant to a known Ag into syngeneic hosts decreased subsequent immune responses to that same Ag (16). In vitro studies confirmed the existence of a subset of CD8 ϩ T cells with the potential to suppress CD4 ϩ T cell responses (17,18).…”

mentioning

confidence: 74%

Cell-Based Immunotherapy with Suppressor CD8+ T Cells in Rheumatoid Arthritis

Dávila

Kang

Park

et al. 2005

The Journal of Immunology

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The chronic persistence of rheumatoid synovitis, an inflammation driven by activated T cells, macrophages, and fibroblasts causing irreversible joint damage, suggests a failure in physiologic mechanisms that down-regulate and terminate chronic immune responses. In vitro CD8+CD28−CD56+ T cells tolerize APCs, prevent the priming of naive CD4+ T cells, and suppress memory CD4+ T cell responses. Therefore, we generated CD8+CD28−CD56+ T cell clones from synovial tissues, expanded them in vitro, and adoptively transferred them into NOD-SCID mice engrafted with synovial tissues from patients with rheumatoid arthritis. Adoptively transferred CD8+CD28−CD56+ T cells displayed strong anti-inflammatory activity. They inhibited production of IFN-γ, TNF-α, and chemokines in autologous and HLA class I-matched heterologous synovitis. Down-regulation of costimulatory ligands CD80 and CD86 on synovial fibroblasts was identified as one mechanism of immunosuppression. We propose that rheumatoid synovitis can be suppressed by cell-based immunotherapy with immunoregulatory CD8+ T cells.

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mentioning

confidence: 74%

Cell-Based Immunotherapy with Suppressor CD8+ T Cells in Rheumatoid Arthritis

Dávila

Kang

Park

et al. 2005

The Journal of Immunology

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“…ϩ Ts from SLE patients was also determined because it has been reported that these cytokines may mediate the suppressor function of CD8 ϩ T lymphocytes (16,23). No differences between SLE patients and healthy subjects were observed.…”

Section: Discussionmentioning

confidence: 99%

Impairment of CD8+ T Suppressor Cell Function in Patients with Active Systemic Lupus Erythematosus

Filaci

Bacilieri

Fravega

et al. 2001

The Journal of Immunology

160

146

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Alteration of T cell suppression function has been recognized in patients with systemic lupus erythematosus (SLE). Recently, CD8+ T suppressor lymphocytes (CD8+ Ts) have been generated in vitro by incubating purified CD8+ T cells with IL-2 and GM-CSF. Using this method, we generated CD8+ Ts from patients affected by SLE. No major differences were found in the CD8+ Ts phenotype between SLE patients and healthy subjects. CD8+ Ts from SLE patients with active disease did not inhibit the anti-CD3 mAb-induced proliferation of autologous PBMC, whereas CD8+ Ts from SLE patients in remission exerted an inhibitory activity comparable to normal subjects. The inhibitory effect of CD8+ Ts cells was neither mediated by cytotoxic activity nor by apoptosis induction. Two cytokines, IFN-γ and IL-6, were found to be responsible for the function of CD8+ Ts. In fact, counteraction of CD8+ Ts suppression activity was obtained by blocking IFN-γ with a specific Ab or by inhibiting CD8+ Ts-mediated IL-6 secretion by an antisense oligonucleotide. Interestingly, CD8+ Ts from SLE patients showed a peculiar cytokine pattern characterized by an impaired secretion of IL-6 and an increased secretion of IL-12. Thus, it appears that an altered balance between inhibitory (IL-6) and stimulatory (IL-12) cytokines might be responsible for the functional impairment of CD8+ Ts in SLE patients.

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“…Also, contrary to initial spec ulations, numerous studies have demonstrated that Ts cells use u|t TCRs to recognize the antigen [for review sec ref. 48].…”

Section: Recent Results and Present K Now Ledge On Ts-cell Circuitmentioning

confidence: 99%

On the Existence of Suppressor Cells

Arnon

Teitelbaum²

1993

Int Arch Allergy Immunol

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Immunological suppression is one of the important aspects which govern the regulation of the immune response. Clonal deletion, clonal anergy and the activity of suppressor cells were proposed as mechanisms leading to this phenomenon. In this review we provide evidence for the existence of suppressor (Ts) cells and their role in autoimmunity in general and particularly in the system of experimental allergic encephalomyelitis (EAE). Ts cell lines and clones that downregulate in-vivo the autoimmune response are described. These results, as well as other recent advances in the understanding of Ts cells regulatory mechanisms and the molecular structures recognized by these cells, lead to the conclusion that Ts cells do exist and that they constitute a distinctive cell type in regard to their function and specificity.

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Suppressor T cells: some answers but more questions

Cited by 52 publications

References 23 publications

Cell-Based Immunotherapy with Suppressor CD8+ T Cells in Rheumatoid Arthritis

Cell-Based Immunotherapy with Suppressor CD8+ T Cells in Rheumatoid Arthritis

Impairment of CD8+ T Suppressor Cell Function in Patients with Active Systemic Lupus Erythematosus

On the Existence of Suppressor Cells

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