Suppressive Effects of Natural and Synthetic Agents on Dextran Sulfate Sodium-induced Interleukin-1β Release from Murine Peritoneal Macrophages

Kwon, Ki Han; Murakami, Akira; Ohigashi, Hajime

doi:10.1271/bbb.68.436

Cited by 16 publications

(9 citation statements)

References 16 publications

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“…All three targeted compounds at single dose (1 g/mL) inhibited TNF-␣ and IL-6 productions induced by LPS. The similar effect on TNF-␣ and IL-6 by GA has also been reported earlier on HMC-1 cells with PMA plus A23187 (Kim et al, 2006) and murine peritoneal macrophages (Kwon et al, 2004). Significant inhibition of TNF-␣ and IL-6 by Oen-A and Oen-B was also observed (p < 0.01).…”

Section: Anti-inflammatory Potential Of Ga Oen-a and Oen-bsupporting

confidence: 87%

HILIC quantification of Oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-α expression in mouse macrophages

Singh

Trivedi

Bawankule

et al. 2012

Journal of Ethnopharmacology

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Section: Anti-inflammatory Potential Of Ga Oen-a and Oen-bsupporting

confidence: 87%

HILIC quantification of Oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-α expression in mouse macrophages

Singh

Trivedi

Bawankule

et al. 2012

Journal of Ethnopharmacology

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“…In mammals, it has been shown that tilorone was a high IFN inducer [24], but this compound induced the production of inflammatory cytokines such as IL6, TNFa and IL12 [39]. Dextran sulfate induced the production of TNFa and IL1b [28,29]. It was possible that the different nature of the cytokines secreted under LPS, tilorone and dextran sulfate influence may explain the differences in modulation of biotransformation activities.…”

Section: Discussionmentioning

confidence: 99%

“…These studies clearly suggested that dextran sulfate depresses drug biotransformation via a factor released by macrophages or Kupffer cells [25e27]. Dextran sulfate has been shown to induce the production of TNFa and IL1b by mammalian macrophages [28,29]. The effects of tilorone and dextran sulfate on biotransformation activities have not been studied in fish.…”

Section: Introductionmentioning

confidence: 99%

Possible implication of macrophages in the regulation of cytochrome P450 activities in carp (Cyprinus carpio)

Marionnet¹,

Deschaux²,

Reynaud³

2006

Fish & Shellfish Immunology

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“…However, the pharmacological effects of rutin and its aglycone may differ, suggesting that the presence of the rutinoside moiety is crucial for some of the protective effects of rutin. In several studies, rutin exerted anti-inflammatory activity, whereas quercetin was either not effective against or actually aggravated the inflammatory response both in vivo and in vitro [9,10] . However, other authors demonstrated that quercetin acted as a strong inhibitor of inflammation in an experimental model of rat colitis [11] .…”

Section: Introductionmentioning

confidence: 99%

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

et al. 2012

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Aim: To investigate the mechanisms underlying the protective effects of quercetin-rutinoside (rutin) and its aglycone quercetin against CCl 4 -induced liver damage in mice. Methods: BALB/cN mice were intraperitoneally administered rutin (10, 50, and 150 mg/kg) or quercetin (50 mg/kg) once daily for 5 consecutive days, followed by the intraperitoneal injection of CCl 4 in olive oil (2 mL/kg, 10% v/v). The animals were sacrificed 24 h later. Blood was collected for measuring the activities of ALT and AST, and the liver was excised for assessing Cu/Zn superoxide dismutase (SOD) activity, GSH and protein concentrations and also for immunoblotting. Portions of the livers were used for histology and immunohistochemistry. Results: Pretreatment with rutin and, to a lesser extent, with quercetin significantly reduced the activity of plasma transaminases and improved the histological signs of acute liver damage in CCl 4 -intoxicated mice. Quercetin prevented the decrease in Cu/Zn SOD activity in CCl 4 -intoxicated mice more potently than rutin. However, it was less effective in the suppression of nitrotyrosine formation. Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl 4 -induced activation of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α) and cyclooxygenase (COX-2). The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin. Treatment with both flavonoids significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers, although quercetin was less effective than rutin at an equivalent dose. Quercetin more potently suppressed the expression of transforming growth factor-β1 (TGF-β1) than rutin. Conclusion: Rutin exerts stronger protection against nitrosative stress and hepatocellular damage but has weaker antioxidant and antiinflammatory activities and antifibrotic potential than quercetin, which may be attributed to the presence of a rutinoside moiety in position 3 of the C ring.

show abstract

Suppressive Effects of Natural and Synthetic Agents on Dextran Sulfate Sodium-induced Interleukin-1β Release from Murine Peritoneal Macrophages

Cited by 16 publications

References 16 publications

HILIC quantification of Oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-α expression in mouse macrophages

HILIC quantification of Oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-α expression in mouse macrophages

Possible implication of macrophages in the regulation of cytochrome P450 activities in carp (Cyprinus carpio)

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

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