Possible implication of macrophages in the regulation of cytochrome P450 activities in carp (Cyprinus carpio)

Pretreatment of mosquito larvae with ultraviolet-B and nitropolycyclic aromatic hydrocarbons induces increased sensitivity to permethrin toxicity

“…UV-B has earlier been used to stimulate esterase activities in mosquitos ( Tetreau et al., 2013 ), but the exact mechanism involved is unknown. This pattern has also been observed in aquatic organisms and it appears to be caused by a significant relationship between ROS on P450 enzyme activity both in-vivo and in-vitro ( Marionnet et al., 2006 ). The majority of GST activity aids in the management of ROS produced by such an oxidative agent ( Yang et al., 2010 ), which explains how GST activity increases in response to UV-B exposure.…”

Cylindrospermopsin induces oxidative stress and genotoxic effects in the fish CLC cell line

“…However, it is also known that mononuclear leucocytes, at least in humans, express a large number of CYP450 isoforms (Siest et al ., ; and references herein). Additionally, the total content of CYP450 in cells isolated from the head kidney and spleen of carp, organs containing a high number of leucocytes, appeared to be similar to that detected in liver cells (Marionnet et al ., ). That identifies leucocytes as potential targets for CYN genotoxicity and may explain the effects observed in WIL2‐NS cells by Humpage et al ().…”

Increased liver protein and mRNA expression of natural killer cell-enhancing factor B (NKEF-B) in ayu (Plecoglossus altivelis) after Aeromonas hydrophila infection

“…Endotoxin clearly could elicit increased ROS production by macrophages in carp [22], and NKEF-B might serve as an antioxidative enzyme countering with such a condition. If expression changes and its multifaceted biological functions were taken together, NKEF-B might play a multifunctional role during the acute inflammation induced by pathogens.…”