Increased liver protein and mRNA expression of natural killer cell-enhancing factor B (NKEF-B) in ayu (Plecoglossus altivelis) after Aeromonas hydrophila infection

Dietary administration of the probiotic SpPdp11: Effects on the intestinal microbiota and immune-related gene expression of farmed Solea senegalensis treated with oxytetracycline

“…This gene encodes the natural killer cell enhancing factor protein, which is included in peroxiredoxin, a family of antioxidant enzymes that protect cells against oxidative damage [74], cell death and tissue repair after injury [75]. The up-regulation of this gene has been reported by LPS treatment or pathogens such as bacteria, viruses and parasites [76][77][78] and suggests that the gene plays a primary role in the innate immune response against bacterial and viral agents [79]. The IGF-β gene encodes for the IGF-β protein, which is a potent inhibitor of apoptosis [80,81] and improves the outcome in the murine sepsis model [82] and hepatic bacterial clearance, likely due to decreased Kupffer cell apoptosis [83].…”

Molecular characterization and expression analysis of six peroxiredoxin paralogous genes in gilthead sea bream (Sparus aurata): Insights from fish exposed to dietary, pathogen and confinement stressors

“…Available literature data show that most infection models of aquatic organisms with bacteria or virus or vaccination procedures mediate an increase in gene or protein expression of PRDXs [28,44,60,61], but some viral and bacterial models [62,63] induce a decrease in the expression of some PRDXs. The observed differences might be due to differences in the challenging agent, the tissue type and the kinetics of the infection making comparative analysis difficult.…”

“…In fish, NKEF-A and B have been characterized in a wide range of teleosts including rainbow trout (Oncorhynchus mykiss) [21], carp (Cyprinus carpio) [22,23], channel catfish (Ictalurus punctatus) [24], Japanese flounder (Paralichthys olivaceus) [25], turbot (Psetta maxima) [26], pufferfish (Tetraodon nigroviridis) [27], ayu (Plecoglossus altivelis) [28], bluefin tuna (Thunnus maccoyii) [29] and lamprey (Lampetra japonica) [30]. Recently, PRDX4 has been cloned and characterized in yellowtail kingfish (Seriola lalandi) [31].…”

Cloning and functional characterisation of a peroxiredoxin 1 (NKEF A) cDNA from Atlantic salmon (Salmo salar) and its expression in fish infected with Neoparamoeba perurans

“…In contrast, NKEF B gene expression was up-regulated in liver, spleen, kidney, brain, heart, gill, skeletal muscle and intestine of ayu (Plecoglossus altivelis) following infection with the pathogenic bacterium Aeromonas hydrophila but not following infection with the non-pathogenic bacterium Vibrio alginolyticus [9]. In another example, NKEF gene expression was up-regulated up to 25-fold in peripheral blood leucocytes of rainbow trout (Oncorhynchus mykiss) infected with viral haemorrhagic septiceamia virus [10].…”