2007
DOI: 10.1080/15287390701434216
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Suppressive Effects of Bisphenol A on the Proliferation of Neural Progenitor Cells

Abstract: Endocrine disruptors (EDs) exert adverse effects on reproductive and immune function or neurological behavior. Bisphenol A (BPA), one of the environmental EDs, is widely used in the manufacture of plastics and epoxy resins. Studies reported that BPA affects reproductive organ growth and development. However, the potential adverse effects of BPA on neuronal development have not been fully explored. In this study, the potent harmful effects of BPA were investigated on the murine-derived multipotent neural progen… Show more

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Cited by 61 publications
(42 citation statements)
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“…Bisphenol A (BPA), is an endocrinedisrupting synthetic xenoestrogen, widely distributed in the environment, and used for the production of number of polycarbonate plastics and epoxy resin-containing consumer products [16,17]. BPA leaches out from the consumer products and upon ingestion crosses the placental and blood-brain barrier, leading to injury to the developing and adult brain [18][19][20][21].…”
Section: Introductionmentioning
confidence: 99%
“…Bisphenol A (BPA), is an endocrinedisrupting synthetic xenoestrogen, widely distributed in the environment, and used for the production of number of polycarbonate plastics and epoxy resin-containing consumer products [16,17]. BPA leaches out from the consumer products and upon ingestion crosses the placental and blood-brain barrier, leading to injury to the developing and adult brain [18][19][20][21].…”
Section: Introductionmentioning
confidence: 99%
“…In some studies, cell proliferation was unaffected by any concentration of BPA that was tested (for example (Dominguez et al, 2008)). In other studies, only monotonic responses were reported for cell proliferation (for example (Kim et al, 2007;Kochukov et al, 2009;Okada et al, 2008;Park et al, 2009)). Finally, still other studies reported non-monotonic responses for cell proliferation (for example (Bouskine et al, 2009;Ricupito et al, 2009;Sheng and Zhu, 2011;Wu et al, 2012)).…”
Section: Nmdrcs Occur For Many Different Endpointsmentioning
confidence: 99%
“…Moreover, a large amount of data has shown that BPA may not only change physiological processes in adults, but also could be destructive and cause alterations in nervous system development with accompanying morphological changes. In vitro, BPA significantly impairs the proliferation of neural progenitor cells and at high-doses it is even cytotoxic to them [10].…”
Section: Introductionmentioning
confidence: 99%