Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms,<i>Lentinus edodes</i>and<i>Agaricus blazei</i>, on the Expression of Cytochrome P450s in Mice

Hashimoto, Takashi; Nonaka, Yasuki; Minato, Ken-ichiro; Kawakami, Sachiko; Mizuno, Masashi; Fukuda, Itsuko; Kanazawa, Kazuki; Ashida, Hitoshi

doi:10.1271/bbb.66.1610

Cited by 35 publications

(27 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Curcumin (50 μM) and monoacetylcurcumin inhibited the 100 ng/ml stimulated NF-κB nuclear translocation, whereas tetrahydrocurcumin did not block the nuclear translocation. It was found that stimulation with LPS results in the activation of Toll-like receptor 4 and the downstream IκB kinases (IKKs), which in turn phosphorylate IκB, the degradation of IκB and the translocation of NF-κB into the nucleus (22). Therefore, the suppressive effects of curcumin, tetrahydrocurcumin and monoacetylcurcumin on the LPS-induced phosphorylation of IκB were examined in RAW264.7 cells (Fig.…”

Section: Resultsmentioning

confidence: 99%

Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation

Nishida

Nishiumi²,

Mizushina³

et al. 2010

Int J Mol Med

View full text Add to dashboard Cite

Abstract. Curcumin, a component of turmeric (Curcuma longa), is known to exert a variety of biological functions including anti-inflammatory activity. We examined the inhibitory effects of chemically synthesized derivatives of curcumin against inflammatory responses and compared them with those of curcumin, in order to find derivatives with stronger effects than curcumin. In a cell culture system using the mouse macrophage cell line RAW264.7, monoacetylcurcumin strongly inhibited IκB phosphorylation, nuclear factor (NF)-κB activation and tumor necrosis factor (TNF)-· production induced by lipopolysaccharide (LPS). In addition, oral administration of monoacetylcurcumin to mice led to greater suppression of TNF-· production after LPS stimulation than the administration of curcumin or tetrahydrocurcumin in vivo. Monoacetylcurcumin also inhibited the LPS-induced NF-κB activation in the liver. Collectively, monoacetylcurcumin is a potential chemopreventive agent for treating inflammatory responses more effectively than curcumin.

show abstract

Section: Resultsmentioning

confidence: 99%

Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation

Nishida

Nishiumi²,

Mizushina³

et al. 2010

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…It is conceivable that the mode of action of BG involves alterations of the activities of enzymes that catalyze activation/detoxification reactions. In this context, it is notable that Japanese groups (Hashimoto et al, 2002;Okamoto et al, 2004) showed recently that fungus-derived polysaccharides inhibit cytochrome P450 1A isoenzymes, including CYP1A2 which catalyzes the first activation step of HAs (N-hydroxylation). Since no protective (c) (d) Figure 4.…”

Section: Resultsmentioning

confidence: 99%

Protective effects of β-glucan extracted from Agaricus brasiliensis against chemically induced DNA damage in human lymphocytes

et al. 2006

View full text Add to dashboard Cite

beta-Glucans (BGs) are polysaccharides that are found in the cell walls of organisms such as bacteria, fungi, and some cereals. The objective of the present study was to investigate the genotoxic and antigenotoxic effects of BG extracted from the mushroom Agaricus brasiliensis (=Agaricus blazei Murrill ss. Heinemann). The mutagenic activity of BG was tested in single-cell gel electrophoresis assays with human peripheral lymphocytes. In addition, the protective effects against the cooked food mutagen 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and (+/-)-anti-B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), which is the main metabolite of B[a]P, and against ROS (H(2)O(2))-induced DNA damage, were studied. The results showed that the compound itself was devoid of mutagenic activity, and that a significant dose-dependent protective effect against damage induced by hydrogen peroxide and Trp-P-2 occurred in the dose range 20-80 microg/ml. To investigate the prevention of Trp-P-2-induced DNA damage, a binding assay was carried out to determine whether BG inactivates the amine via direct binding. Since no such interactions were observed, it is likely that BG interacts with enzymes involved in the metabolism of the amine.

show abstract

“…9 Some authors have also described this activity in cytokine release or phagocytosis stimulation. 5 Also, increases in the production of interferons and interleukins, preventing viruses and other external factors from entering the tissue, have been found. 10 Considering all the effects found for the immune stimulating activity of A. blazei extracts and its relation to many physiological processes, like inflammation, the aim of this study was to evaluate alkaline and aqueous extracts of this edible mushroom in different models of inflammation.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity of Aqueous and Alkaline Extracts from Mushrooms (Agaricus blazei Murill)

Padilha

Avila

Sousa

et al. 2009

Journal of Medicinal Food

View full text Add to dashboard Cite

The effects of aqueous and alkaline extracts from Agaricus blazei Murill, an edible mushroom used as folk medicine in Brazil, Japan, and China to treat several illnesses, were investigated on the basis of the inflammatory process induced by different agents. Oral administration of A. blazei extracts marginally inhibited the edema induced by nystatin. In contrast, when complete Freund's adjuvant was used as the inflammatory stimulus, both extracts were able to inhibit this process significantly (P < .05, analysis of variance followed by Tukey-Kramer multiple comparison post hoc test), although it inhibited the granulomatous tissue induction moderately. These extracts were able to decrease the ulcer wounds induced by stress. Also, administration of extracts inhibited neutrophil migration to the exudates present in the peritoneal cavity after carrageenin injection. Therefore, it is possible that A. blazei extracts can be useful in inflammatory diseases because of activation of the immune system and its cells induced by the presence of polysaccharides such as beta-glucans.

show abstract

Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms,Lentinus edodesandAgaricus blazei, on the Expression of Cytochrome P450s in Mice

Cited by 35 publications

References 21 publications

Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation

Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation

Protective effects of β-glucan extracted from Agaricus brasiliensis against chemically induced DNA damage in human lymphocytes

Anti-Inflammatory Activity of Aqueous and Alkaline Extracts from Mushrooms (Agaricus blazei Murill)

Contact Info

Product

Resources

About