Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans

Sakamoto, Ichiko; Igarashi, Muneki; Kimura, Katsunori; Takagi, Atsushi; Miwa, Takeshi; Koga, Yuichi

doi:10.1093/jac/47.5.709

Cited by 268 publications

(165 citation statements)

References 5 publications

(7 reference statements)

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“…The effect of 90 g of yogurt with L. gasseri OLL2716 (LG21) administered twice daily for 8 weeks in 29 asymptomatic adults was evaluated by means of the 13 C-UBT and the pepsinogen I/ II ratio as a marker of gastric inflammation. 55 LG21 decreased significantly DOB values in comparison with baseline measurements and reduced the intensity of gastric inflammation as indicated by the lower pepsinogen I/II ratio. Similar results were obtained with LG21 in children.…”

mentioning

confidence: 81%

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

Gotteland

Brunser

Cruchet

2006

Aliment Pharmacol Ther

221

168

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SUMMARYHelicobacter pylori is a highly prevalent pathogen considered as an aetiological factor for gastroduodenal ulcers, and a risk factor for gastric adenocarcinoma and lymphoma in humans. Most subjects colonized by this micro-organism are asymptomatic and remain untreated. In symptomatic patients, the antibiotic treatment has a high cost and is not 100% effective because of resistance to antibiotics and to moderate patient compliance. This review discusses the role of probiotics as alternative solutions to assist in the control of H. pylori colonization in atrisk populations.The evidence that some strains of Lactobacillus and Bifidobacterium are able to inhibit H. pylori growth through the release of bacteriocins or organic acids, and may also decrease its adhesion to epithelial cells, is reviewed. In addition, probiotics have a possible role in the stabilization of the gastric barrier function and the decrease of mucosal inflammation. Other aspects that are considered are the contribution of probiotics to the healing of the gastric mucosa linked to their antioxidant and anti-inflammatory properties.Clinical trials in colonized adults and children are reviewed, and suggest that probiotics do not eradicate H. pylori but maintain lower levels of this pathogen in the stomach; in combination with antibiotics, probiotics may increase eradication rate and/or decrease adverse effects. Papers suggesting similar effects on H. pylori by foodstuffs such as berry juice and some milk proteins are quoted. Regular intake of these and other dietary products might constitute a low-cost, large-scale alternative solution applicable for populations at-risk for H. pylori colonization.

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mentioning

confidence: 81%

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

Gotteland

Brunser

Cruchet

2006

Aliment Pharmacol Ther

221

168

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“…These findings lead to the speculation that we are supposed to domesticate H pylori through restoring the homeostasis of the gastric microecosystem. It was reported that administration of exogenous Lactobacilli has therapeutic effects on H pylori-associated diseases by interfering with the pathogenetic progress of H pylori [27][28][29][30] . Inhibition of H pylori-induced proinflammatory factor production by Lactobacilli is a very important aspect.…”

Section: Viable Lbg or Lbg-s Inhibited H Pyloriss1-lps-induced Il-8 Pmentioning

confidence: 99%

Lactobacilli inhibit interleukin-8 production induced by Helicobacter pylori lipopolysaccharide-activated Toll-like receptor 4

Zhou¹,

Ma²,

Deng³

et al. 2008

WJG

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METHODS: S G C-7901 c el ls were t reat ed wi t h H pylori SS1-LPS in the presence or absence of pretreatment for 1 h with viable LBG or supernatant recovered from LBG culture MRS broth (LBG-S ). Cellular lysates were prepared for Western blot with anti-TLR4, anti-transforming growth factor β-activated kinase 1 (TAK1), anti-phospho-TAK1, anti-nuclear factor κB (NF-κB), anti-p38 mitogen-activated protein kinase (p38MAPK), and anti-phospho-p38MAPK antibodies. The amount of IL-8 in cell culture medium was measured by ELISA. R E S U LT S : H p y l o r i S S 1 -L P S u p -r e g u l a t e d t h eexpression of TLR4, stimulated the phosphorylation of TAK1, subsequently enhanced the activation of NF-κB and the phosphorylation of p38MAPK in a timedependent manner, leading to augmentation of IL-8 production in SGC-7901 cells. Viable LBG or LBG-S pretreatment attenuated the expression of TLR4, inhibited the phosphorylation of TAK1 and p38MAPK, prevented the activation of NF-κB, and consequently blocked IL-8 production.

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“…Los estudios actuales que analizan la colonización del estómago por lactobacilos utilizan alimentos probióticos que contienen cepas de origen intestinal, cuyo mecanismo de protección frente a la colonización por H pylori es desconocido [38][39][40] .…”

Section: Discussionunclassified

Propiedades probióticas de Lactobacillus spp aislados de biopsias gástricas de pacientes con y sin infección por Helicobacter pylori

C¹,

A²,

R³

et al. 2009

Rev. méd. Chile

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Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans

Cited by 268 publications

References 5 publications

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?

Lactobacilli inhibit interleukin-8 production induced by Helicobacter pylori lipopolysaccharide-activated Toll-like receptor 4

Propiedades probióticas de Lactobacillus spp aislados de biopsias gástricas de pacientes con y sin infección por Helicobacter pylori

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