Suppressive Effect of Astaxanthin on Lipid Peroxidation Induced in Rats.

Nishigaki, Ikuo; Dmitrovskii, A. A.; Miki, Wataru; Yagi, Kazuichi

doi:10.3164/jcbn.16.161

Cited by 26 publications

(11 citation statements)

References 14 publications

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“…However, the mechanism by which astaxanthin exerts its effect in these systems is not known. Several recent in vitro studies have reported that astaxanthin is an effective inhibitor of lipid peroxidation in the microsomal membrane, suggesting that its suppressing effect is more potent than that of ␣-tocopherol (24,25). Moreover, the presence of astaxanthin inhibited the loss of ␣-tocopherol (24).…”

Section: Discussionmentioning

confidence: 99%

Effect of Astaxanthin in Combination with .ALPHA.-Tocopherol or Ascorbic Acid against Oxidative Damage in Diabetic ODS Rats

Nakano

Onodera

Saito

et al. 2008

J Nutr Sci Vitaminol

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SummaryThe present study was performed to investigate the effect of astaxanthin in combination with other antioxidants against oxidative damage in streptozotocin (STZ)-induced diabetic Osteogenic Disorder Shionogi (ODS) rats. Diabetic-ODS rats were divided into five groups: control, astaxanthin, ascorbic acid, ␣ -tocopherol, and tocotrienol. Each of the four experimental groups was administered a diet containing astaxanthin (0.1 g/kg), in combination with ascorbic acid (3.0 g/kg), ␣ -tocopherol (0.1 g/kg), or tocotrienol (0.1 g/ kg) for 20 wk. The effects of astaxanthin with other antioxidants on lipid peroxidation, urinary 8-hydroxy-2 ′ -deoxyguanosine (8-OHdG) excretion, serum creatinine (Cr) level, creatinine clearance (Ccr), and urinary protein content were assessed. The serum lipid peroxide levels and chemiluminescent (CL) intensity in the liver of the ␣ -tocopherol and tocotrienol groups were significantly reduced in comparison to that of the control group. In the ␣ -tocopherol group, urinary 8-OHdG excretion, serum Cr level, Ccr, urinary albumin excretion, and urinary protein concentration were significantly decreased as compared with those in the control group. Additionally, the CL intensity in the kidney of the ␣ -tocopherol group was significantly lower, but that of the ascorbic acid group was significantly higher than that in the control group. These results indicate that dietary astaxanthin in combination with ␣ -tocopherol has an inhibitory effect on oxidative stress. On the other hand, our study suggests that excessive ascorbic acid intake increases lipid peroxidation in diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Effect of Astaxanthin in Combination with .ALPHA.-Tocopherol or Ascorbic Acid against Oxidative Damage in Diabetic ODS Rats

Nakano

Onodera

Saito

et al. 2008

J Nutr Sci Vitaminol

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“…In experiments on rats, AX was found to cross the brain–blood barrier and exhibit effects on the brain. (17) It was reported that AX exists as a combined form with water-soluble substances like proteins in aqueous solutions, and that AX in its combined form shows superoxide scavenging effects and is considered to function directly and indirectly for the scavenging of this ROS. (18–20) …”

Section: Discussionmentioning

confidence: 99%

Effects of astaxanthin on antioxidation in human aqueous humor

Hashimoto

Arai

Hayashi

et al. 2013

J. Clin. Biochem. Nutr.

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We evaluated the antioxidative effects of astaxanthin through the changes in superoxide scavenging activity, levels of hydrogen peroxide and total hydroperoxides in human aqueous humor. The study subjects were 35 patients who underwent bilateral cataract surgery on one side before and the other side after intake of astaxanthin (6 mg/day for 2 weeks). Their aqueous humor was taken during the surgery and subjected to measurements of the three parameters. After astaxanthin intake, the superoxide scavenging activity was significantly (p<0.05) elevated, while the level of total hydroperoxides was significantly (p<0.05) lowered. There was a significant negative correlation between the superoxide scavenging activity and the level of total hydroperoxides (r = −0.485, p<0.01), but no correlations between the hydrogen peroxide level and the other two parameters. Astaxanthin intake clearly enhanced the superoxide scavenging activity and suppressed the total hydroperoxides production in human aqueous humor, indicating the possibility that astaxanthin has suppressive effects on various oxidative stress-related diseases.

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“…En este sentido, los carotenoides poseen propiedades químicas y biológicas en la nutrición de los peces, que se relacionan con procesos metabólicos, inmunidad, pigmentación y reproducción. Además, los carotenoides protegen ante los efectos de compuestos oxidantes y peroxidantes (Luquet & Watanabe, 1986;Burton, 1989;Kurshize et al, 1990;Krinsky, 1993;Nishigaki et al, 1994).…”

Section: Introductionunclassified

Efecto del suplemento de astaxantina sobre la calidad seminal en Moenkhausia sanctaefilomenae (Teleostei: Characidae)

Domínguez-Castanedo

Toledano-Olivares

Ávalos-Rodrı́guez

2015

lajar

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RESUMEN. Se caracterizó la morfometría de los espermatozoides del teleósteo Moenkhausia sanctaefilomenae, y se evaluó el efecto de la suplementación del carotenoide astaxantina en la dieta sobre la calidad de semen. La morfometría de los espermatozoides se realizó con microscopia óptica con la tinción de eosinanigrosina vista en fluorescencia. La calidad de semen de 360 peces se evaluó con espermogramas clásicos (concentración, volumen, motilidad y viabilidad). La longitud total del espermatozoide fue de 16,83 ± 2,33 µm, diámetro de la cabeza sin acrosoma de 1,93 ± 0,21 µm, diámetro de la pieza media de 0,91 ± 0,23 µm y longitud del flagelo de 13,18 ± 1,76 µm. En los peces del grupo control, el volumen seminal y la concentración espermática fue de 2,14 ± 1,55 µL y 6,8x10 8 ± 292,82 respectivamente. La adición de astaxantina incrementó significativamente (P < 0,05) estos parámetros a 3,87 ± 1,06 µL y 13x10 8 ± 265,56 respectivamente. La motilidad no varió significativamente entre el grupo control (3,14 ± 1,46) y astaxantina (3,50 ± 0,92). Los resultados indicaron una tendencia hacia el incremento de la calidad seminal en el grupo tratado con astaxantina. Este incremento se puede atribuir a sus propiedades antioxidantes que protegen a las células testiculares contra el estrés oxidativo, con lo cual, se mejora el potencial reproductor de esta especie en condiciones de cultivo. Palabras clave: Moenkhausia sanctaefilomenae, astaxantina, calidad de semen, espermatozoide, carotenoides, acuicultura. Effect of astaxanthin supplementation on semen quality inMoenkhausia sanctaefilomenae (Teleostei: Characidae)ABSTRACT. This study was set out to: i) characterize the morphometry of spermatozoa of M. sanctaefilomenae; and ii) evaluate the effect on the quality of semen by astaxanthin supplementation in the diet. The morphometry of the sperm was analyzed by optical microscopy (nigrosin-eosin staining). Semen quality of 360 fish was evaluated by spermograms (volume, total number, motility and viability). The length of the sperms was 16.83 ± 2.33 μm, the head diameter was 1.93 ± 0.21 μm without acrosome, the midpiece diameter was 0.91 ± 0.23 μm and the length of the flagellum was 13.18 ± 1.76 μm. In fish unexposed to astaxanthin (control group) the seminal volume and the total number of sperms was 2.14 ± 1.55 μL and 6.8x10 8 ± 29, respectively. The addition of astaxanthin in the diet significantly increased (P < 0.05) these parameters to 3.87 ± 1.06 μL and 13x10 8 ± 26, respectively. The motility of the sperms and the sperm viability did not differ between both groups (P > 0.05). The results suggest that astaxanthin improves some parameters of the semen quality (volume and total number). This improvement may be attributable to the antioxidant properties (i.e., protection against oxidative stress in testicular cell structures) of astaxanthin.

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Suppressive Effect of Astaxanthin on Lipid Peroxidation Induced in Rats.

Cited by 26 publications

References 14 publications

Effect of Astaxanthin in Combination with .ALPHA.-Tocopherol or Ascorbic Acid against Oxidative Damage in Diabetic ODS Rats

Effect of Astaxanthin in Combination with .ALPHA.-Tocopherol or Ascorbic Acid against Oxidative Damage in Diabetic ODS Rats

Effects of astaxanthin on antioxidation in human aqueous humor

Efecto del suplemento de astaxantina sobre la calidad seminal en Moenkhausia sanctaefilomenae (Teleostei: Characidae)

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