Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8

Hoffmann, Christian J.; Hohberg, Margret; Chlench, Sven; Maroski, Julian; Drab, Marek; Siegel, G.; Pries, Axel R.; Zakrzewicz, Andreas

doi:10.1016/j.atherosclerosis.2011.01.017

Cited by 10 publications

(11 citation statements)

References 15 publications

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“…[ [135][136][137][138][139][140][141][142][143][144][145][146] VESICULAR TRAFFICKING AND CELL MIGRATION RHOD and RRAS2 are two of most important hub genes of GTPase family. The downexpression of RHOD could impair migration and proliferation of RPE cells.…”

Section: Retinoic Acid Cycle (Rdh5 Mkv)mentioning

confidence: 99%

RETRACTED ARTICLE: Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis

et al. 2018

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Retinitis pigmentosa (RP) is a very heterogeneous inherited ocular disorder group characterized by progressive retinal disruption. Retinal pigment epithelium (RPE) degeneration, due to oxidative stress which arrests the metabolic support to photoreceptors, represents one of the principal causes of RP. Here, the role of oxidative stress in RP onset and progression was analyzed by a comparative whole transcriptome analysis of human RPE cells, treated with 100 µg/ml of oxLDL and untreated, at different time points. Experiment was thrice repeated and performed on Ion Proton TM sequencing system. Data analysis, including low quality reads trimming and gene expression quantification, was realized by CLC Genomics Workbench software. The whole analysis highlighted 14 clustered "macro-pathways" and many sub-pathways, classified by selection of 5271 genes showing the highest alteration of expression. Among them, 23 genes were already known to be RP causative ones (15 over-expressed and 8 down-expressed), and their enrichment and intersection analyses highlighted new 77 candidate related genes (49 over-expressed and 28 down-expressed). A final filtering analysis then highlighted 29 proposed candidate genes. This data suggests that many new genes, not yet associated with RP, could influence its etiopathogenesis.

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Section: Retinoic Acid Cycle (Rdh5 Mkv)mentioning

confidence: 99%

RETRACTED ARTICLE: Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis

et al. 2018

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“…This was most unexpected for IL-8 expression, as this molecule is often co-regulated with IL-6 and plays a prominent role in various infectious and inflammatory diseases. IL-8 production is induced by oxLDL and high oxLDL/LDL ratios have been shown to correlate with increased IL-8 serum levels in humans [26]. The predominant regulation via alternative receptors like LOX-1 could thus be the reason for increased IL-8 release in response to increasing CRP stimulation, without dependency on the genotype of the FcγRIIa.…”

Section: Discussionmentioning

confidence: 98%

The proinflammatory effect of C-reactive protein on human endothelial cells depends on the FcγRIIa genotype

Raaz‐Schrauder¹,

Ekici²,

Klinghammer³

et al. 2014

Thrombosis Research

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“…10,24]. In the present metabolic syndrome study, changes in nanoplaque formation were well correlated to changes in oxLDL/LDL ratio (r = 0.83; p < 0.0210).…”

Section: Resultsmentioning

confidence: 49%

The significance of lipid peroxidation in cardiovascular disease

Siegel

Ermilov

Pries

et al. 2014

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Background: The metabolic syndrome describes a cluster of cardiovascular risk factors that frequently appear together. Its diagnosis is generally based on several well-recognized indicators in clinical practice, such as abdominal obesity, elevated triglycerides, reduced highdensity lipoprotein, raised blood pressure, and elevated fasting plasma glucose. Today, decisive importance must be attached to the metabolic syndrome since it leads to increased morbidity and mortality, and thus to a decreased life expectancy, and to higher direct and indirect healthcare costs. This is also due to the fact that its symptomatology irradiates on many organs of the body, which may thereby be damaged. Methods: In the present clinical trial on 11 metabolic syndrome patients treated with Ginkgo biloba (EGb 761, 2  120 mg/d) for two months, ellipsometry, fluorescence microscopy, photometric methods, ELISAs and EIAs were applied for biosensor profiling of metabolic syndrome risk, status and treatment outcome. Results: A spectrum of more than 20 arteriosclerotic, cytokinic, inflammatory, lipidic, and oxidative stress biomarkers served for a detailed diagnosis and therapy monitoring. After medication, the ratio oxLDL/LDL was reduced by 21.0%, 8-iso-PGF 2α 39.8%, MPO 29.6%, IL-6 12.9%, hs-CRP 39.3%, Lp(a) 26.3%, MMP-9 32.9%, insulin 9.4%, HOMA-IR 14.0%, ALP 14.8%, CREA 11.3%, URAC 10.6%, in vitro modelled nanoplaque formation 14.3% and size 23.4%, whereas SOD was augmented by 17.7%, GPx 11.6%, cAMP 43.5%, and cGMP 32.9%. Special focus was concentrated on the significance of lipid peroxidation for cardio-cerebro-vascular diseases. Through multiple correlations between the biomarkers and clinical parameters, their significance for and involvement in several clinical pictures could be elucidated. Conclusion: The present clinical observational study was helpful in unravelling this network of biomarker interactions and demonstrated its usefulness for theranostics. For personalized medicine, the selection of the biomarkers is of decisive importance. On the background of a growing obesity among children and adolescents with an increase in prevalence of the metabolic syndrome, diagnosing this syndrome in young subjects may be helpful in identifying a population of risk for increased subclinical arteriosclerosis.

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Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8

Cited by 10 publications

References 15 publications

RETRACTED ARTICLE: Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis

RETRACTED ARTICLE: Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis

The proinflammatory effect of C-reactive protein on human endothelial cells depends on the FcγRIIa genotype

The significance of lipid peroxidation in cardiovascular disease

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