2018
DOI: 10.1080/15384101.2018.1558873
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Abstract: Retinitis pigmentosa (RP) is a very heterogeneous inherited ocular disorder group characterized by progressive retinal disruption. Retinal pigment epithelium (RPE) degeneration, due to oxidative stress which arrests the metabolic support to photoreceptors, represents one of the principal causes of RP. Here, the role of oxidative stress in RP onset and progression was analyzed by a comparative whole transcriptome analysis of human RPE cells, treated with 100 µg/ml of oxLDL and untreated, at different time point… Show more

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Cited by 16 publications
(19 citation statements)
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References 207 publications
(149 reference statements)
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“…Oxidative stress is considered one of the most significant biochemical pathways involved in RP etiopathogenesis, especially targeting the high metabolic demand of RPE cells. Metabolic dysfunctions (e.g., ceramide synthesis [74]) and impairment of high energy processes as life-long light illumination or physiological phagocytosis could determine pathological modifications in blood-retinal barrier (BRB) and in other extracellular matrix molecules, leading to photoreceptor outer segments (POSs) processing inhibition and RPE cells apoptosis [75,76].…”
Section: Discussionmentioning
confidence: 99%
“…Oxidative stress is considered one of the most significant biochemical pathways involved in RP etiopathogenesis, especially targeting the high metabolic demand of RPE cells. Metabolic dysfunctions (e.g., ceramide synthesis [74]) and impairment of high energy processes as life-long light illumination or physiological phagocytosis could determine pathological modifications in blood-retinal barrier (BRB) and in other extracellular matrix molecules, leading to photoreceptor outer segments (POSs) processing inhibition and RPE cells apoptosis [75,76].…”
Section: Discussionmentioning
confidence: 99%
“…underlying photoreceptor degeneration might afford an alternative therapeutic target (Sancho-Pelluz et al, 2008). For instance, excessive oxidative stress contributes to the photoreceptor degeneration with variable etiologic backgrounds (Tsuruma et al, 2012;Narayan et al, 2016;Donato et al, 2019). This is the rationality to build the therapeutic strategy on antioxidants.…”
Section: Discussionmentioning
confidence: 99%
“…Oxidative stress, recently defined as "a state where oxidative forces exceed the antioxidant systems due to loss of the balance between them", represents one of the principal inductors of lifestyle-related and genetic diseases [1]. Among them, retinal dystrophies and, in particular, age-related macular degeneration (AMD) and the subgroup of retinitis pigmentosa (RP) are well known to be susceptible to oxidative stress [2,3]. Nowadays AMD is considered the principal cause of visual disability among patients over 50 years [4].…”
Section: Introductionmentioning
confidence: 99%