Suppression of the Inhibitory Effect of circ_0036176-Translated Myo9a-208 on Cardiac Fibroblast Proliferation by miR-218-5p

Guo, Jing; Chen, Liwen; Huang, Zhiqi; Guo, Ji-Shen; Li, Hui; Shan, Yue; Chen, Ze-Run; Yan, Yu-Min; Zhu, Ji-Xiao; Guo, Huiming; Fang, Xianhong; Shan, Zhi‐Xin

doi:10.1007/s12265-022-10228-x

Cited by 19 publications

(9 citation statements)

References 40 publications

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“…For instance, circRNA circ_0036176 can encode a 208-amino-acid protein (Myo9a-208) that suppresses cardiac fibroblast proliferation. Interestingly, miRNA miR-218-5p can directly bind to circ_0036176 and inhibit the translation of Myo9a-208 [ 99 ]. Cardiac fibrosis is caused by the accumulation of extracellular collagen proteins in the heart leading to systolic or diastolic dysfunction.…”

Section: The Role Of Circrnas In Cvdsmentioning

confidence: 99%

Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Wang

Spanos

et al. 2023

Research

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Cardiovascular disease is one of the leading causes of mortality worldwide. Recent studies have shown that circular RNAs (circRNAs) have emerged as important players in the prevention and treatment of cardiovascular diseases. circRNAs are a class of endogenous noncoding RNAs that are generated by back-splicing and are involved in many pathophysiological processes. In this review, we outline the current research progress on the regulatory roles of circRNAs in cardiovascular diseases. Further, new technologies and methods available for identifying, validating, synthesizing, and analyzing circRNAs, as well as their applications in therapeutics, are highlighted here. Moreover, we summarize the increasing insights into the potential use of circRNAs as circulating diagnostic and prognostic biomarkers. Finally, we discuss the prospects and challenges of circRNA therapeutic applications for cardiovascular disease therapy, with a particular focus on developing circRNA synthesis and engineering delivery systems.

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Section: The Role Of Circrnas In Cvdsmentioning

confidence: 99%

Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Wang

Spanos

et al. 2023

Research

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“…It has been revealed that circ_0036176 contains an IRES element and a 627 nt ORF with the ability to encode a protein containing 208 amino acids named Myo9a-208, which in turn inhibits the cyclin/Rb pathway to hinder the proliferation of cardiac fibroblasts with a protective effect. 97 Hence, a better understanding of the molecular mechanisms by which circRNA regulate cardiac fibrosis would facilitate the discovery of new therapeutic approaches for the development of cardiac remodeling. Based on current understanding, more effort needs to be expended to identify more circRNA, not only screening and analyzing circRNA's expression patterns, but also understanding more mechanisms and processes in pathologic mechanisms.…”

Section: Circrna Encoding Protein In Cardiac Fibrosismentioning

confidence: 99%

“…-associated protein (YAP) and facilitate its localization in the nucleus to promote cell proliferation and growth[96] circ_0036176 Downregulated Translate Myo9a-208 protein Inhibit CFs proliferation by translating Myo9a-208 protein and suppressing cyclin/Rb pathway[97] …”

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confidence: 99%

Circular RNA: A new expectation for cardiovascular diseases

Xie,

Ma,

Ren

et al. 2023

J of Cellular Biochemistry

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Circular RNA (circRNA) is a class of RNA with the 5' and 3' ends connected covalently to form a closed loop structure and characterized by high stability, conserved sequences and tissue specificity, which is caused by special reverse splicing methods. Currently, it has become a hot spot for research. With the discovery of its powerful regulatory functions and roles, the molecular mechanisms and future value of circRNA in participating in and regulating biological and pathological processes are becoming increasingly apparent. Among them is the increasing prevalence of cardiovascular diseases (CVDs). Many studies have elucidated that circRNA plays a crucial role in the development and progression of CVDs. Therefore, circRNA shows its advantages and brilliant expectations in the field of CVDs. In this review, we describe the biogenesis, bioinformatics detection and function of circRNA and discuss the role of circRNA and its effects on CVDs, including atherosclerosis, myocardial infarction, cardiac hypertrophy and heart failure, myocardial fibrosis, cardiac senescence, pulmonary hypertension, and diabetic cardiomyopathy by different mechanisms. That shows circRNA advantages and brilliant expectations in the field of CVDs.

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“…OE-circ_0036176-exo could inhibit the proliferation by translating Myo9a-208 protein to suppress the expression of CCND1, CCNE1, CDK9, and p-RB1 in CFs. While miR-218-5p could bind to circ_0036176 to suppress Myo9a-208 expression at the transcriptional level, thereby attenuating the inhibitory effect of circ_0036176 on mouse CF proliferation ( Guo et al, 2022 ).…”

Section: Overview Of Exosomal Circular Rnas In Cvdsmentioning

confidence: 99%

Exosomal circular RNAs: Biogenesis, effect, and application in cardiovascular diseases

Qin

Yan

et al. 2022

Front. Cell Dev. Biol.

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As natural nanoparticles, exosomes regulate a wide range of biological processes via modulation of its components, including circular RNAs (circRNAs). CircRNAs are a novel class of closed-loop single-stranded RNAs with a wide distribution, and play diverse biological roles. Due to its stability in exosomes, exosomal circRNAs serve as biomarkers, pathogenic regulators and exert therapeutic potentials in some cardiovascular diseases, including atherosclerosis, acute coronary syndrome, ischemia/reperfusion injury, heart failure, and peripheral artery disease. In this review, we detailed the current knowledge on the biogenesis and functions of exosomes, circRNAs, and exosomal circRNAs, as well as their involvement in these cardiovascular diseases, providing novel insights into the diagnosis and treatment of these diseases.

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Suppression of the Inhibitory Effect of circ_0036176-Translated Myo9a-208 on Cardiac Fibroblast Proliferation by miR-218-5p

Cited by 19 publications

References 40 publications

Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Circular RNA: A new expectation for cardiovascular diseases

Exosomal circular RNAs: Biogenesis, effect, and application in cardiovascular diseases

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