Suppression of Sensory Irritation by Chamomile Essential Oil and Its Active Component - Bisabololoxide A

Kobayashi, Yuri Teiichi da Silva; Suzuki, Akiko; Kobayashi, Akiko; Kasai, Akira; Ogata, Yoshiro; Kumada, Y.; Takahashi, R.; Ogino, Fumiko

doi:10.17660/actahortic.2007.749.17

Cited by 5 publications

(4 citation statements)

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“…The stimulus property of Silica-PAMAM-Cap was also estimated by a paw licking test. 27,28 A typical example was as follows. The mice were placed individually for adaptation, 20 min before testing, into transparent plastic cages, which subsequently served as observation chambers.…”

Section: Evaluation Of Stimulus Property Of Silica-pamam-cap By a Pawmentioning

confidence: 99%

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Immobilization of capsaicin onto silica nanoparticle surface and stimulus properties of the capsaicin‐immobilized silica

Yamauchi

Saitoh

Shirai

et al. 2010

J. Polym. Sci. A Polym. Chem.

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To prepare silica nanoparticle having biorepellent activity, the immobilization of capsaicin onto hyperbranched poly(amidoamine) (PAMAM)-grafted silica was investigated. Grafting of PAMAM onto a silica surface was achieved in a solvent-free dry system using PAMAM dendrimer synthesis methodology. The immobilization of capsaicin was achieved by the reaction of hydroxyl groups of capsaicin with isocyanate groups of Silica-PAMAM, which were introduced by the reaction of terminal amino groups of Silica-PAMAM with hexamethylene diisocyanate. The immobilization of capsaicin was confirmed by thermal decomposition GC-MS. The amount of capsaicin immobilized onto PAMAM-grafted silica was determined to be 0.10 mmol/g. Capsaicin-immobilized Silica-PAMAM (Silica-PAMAM-Cap) was dispersed uniformly in water and Tyrode solution. Stimulus activity of Silica-PAMAM-Cap was estimated using two stimulus tests, that is a magnus test and a paw licking test, to sensory nerve of mice. As the result of magnus test, it was found that the Silica-PAMAM-Cap shows stimulus activity. It was found that elution of capsaicin could be depressed by immobilizing capsaicin onto Silica-PAMAM from the result of paw licking test. In addition, the stimulus property of Silica-PAMAM-Cap to the human skin could be observed and it was found that Silica-PAMAM-Cap had acrid taste.

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Section: Evaluation Of Stimulus Property Of Silica-pamam-cap By a Pawmentioning

confidence: 99%

“…The stimulus property of Silica-PAMAM-Cap was estimated by a magnus test. 27 A typical example was as follows. The abdominal cavity of mouse was opened, and the segments of the ileum was quickly excised and placed in Tyrode solution at room temperature.…”

Section: Evaluation Of Stimulus Property Of Silica-pamam-cap By a Magnus Testmentioning

confidence: 99%

Immobilization of capsaicin onto silica nanoparticle surface and stimulus properties of the capsaicin‐immobilized silica

Yamauchi

Saitoh

Shirai

et al. 2010

J. Polym. Sci. A Polym. Chem.

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“…In addition to these beneficial effects, chamomile also exhibits antipruritic activity in humans (Graf, 2000;Patzelt-Wenczler and Ponce-Pöschl, 2000) and experimental animals (Kobayashi et al, 2003(Kobayashi et al, , 2005. Bisabololoxide A (BSBO), one of the main constituents in German chamomile extract (Matos et al, 1993;Mimica-Dukic et al, 1993), is essential for its antipruritic activity (Kobayashi et al, 2007). Micromolar concentrations of BSBO suppressed sensory irritation under in vitro conditions (Kobayashi et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Bisabololoxide A (BSBO), one of the main constituents in German chamomile extract (Matos et al, 1993;Mimica-Dukic et al, 1993), is essential for its antipruritic activity (Kobayashi et al, 2007). Micromolar concentrations of BSBO suppressed sensory irritation under in vitro conditions (Kobayashi et al, 2007). Pruritis is commonly observed in individuals with skin disorders.…”

Section: Introductionmentioning

confidence: 99%

Bisabololoxide A, One of the Constituents in German Chamomile Extract, Attenuates Cell Death Induced by Calcium Overload

et al. 2013

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Bisabololoxide A (BSBO), main constituents in German chamomile extract, is responsible for antipruritic effect. In previous study, the incubation with 30-100 μM BSBO for 24 h exerted cytotoxic and proapoptotic effects on rat thymocytes. To further characterize BSBO cytotoxicity, the effect on the cells suffering from calcium overload by calcium ionophore A23187 was examined. A23187 induced Ca(2+) -dependent cell death. Contrary to our expectation, 1-10 μM BSBO inhibited A23187-induced increase in cell lethality of rat thymocytes. BSBO attenuated A23187-induced increases in populations of shrunken living cells, phosphatidylserine-exposed living cells, and dead cells, without affecting the increase in intracellular Ca(2+) concentration and the Ca(2+) -dependent hyperpolarization. The effect of BSBO on A23187-treated cells may be unique because the activation of Ca(2+) -dependent K(+) channels is required for cell shrinkage, externalization of phosphatidylserine, and cell death in some cells. The cell death induced by A23187 was not inhibited by Z-VAD-FMK, a pan-inhibitor of caspases. Thus, the cell death may be a necrosis with some features observed during an early stage of apoptosis. These results suggest that BSBO at low micromolar concentrations is cytoprotective against calcium overload.

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Medicinal and Aromatic Plants in the Southern Cone

Máthé

Bandoni

2021

Medicinal and Aromatic Plants of the World

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Suppression of Sensory Irritation by Chamomile Essential Oil and Its Active Component - Bisabololoxide A

Cited by 5 publications

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Immobilization of capsaicin onto silica nanoparticle surface and stimulus properties of the capsaicin‐immobilized silica

Immobilization of capsaicin onto silica nanoparticle surface and stimulus properties of the capsaicin‐immobilized silica

Bisabololoxide A, One of the Constituents in German Chamomile Extract, Attenuates Cell Death Induced by Calcium Overload

Medicinal and Aromatic Plants in the Southern Cone

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