Suppression of murine lymphocyte proliferation induced by a small RNA purified from theTaenia solium metacestode

Neurocysticercosis, the most common parasitic disease of the central nervous system, is caused by cysticerci of the helminth Taenia solium, which is prevalent in developing countries and is reemerging in affluent societies. This helminth is associated with brain tumors and hematological malignancies in humans. In the present study, we analyzed the genotoxicity of vesicular fluid (VF) and a saline extract (SE) of T. solium metacestodes in the Drosophila melanogaster wing somatic mutation and recombination test (SMART). Third-instar larvae derived from standard and high bioactivation crosses were treated for approximately 48 hr with 12.5, 25.0, and 50.0 microg/ml of VF and SE of T. solium metacestodes. Negative (phosphate buffered saline) and positive (10 mM urethane) controls were also included. The results showed that the two test compounds were genotoxic in both crosses of Drosophila. Nevertheless, further research is needed to determine the genotoxic potential of specific compounds present in VF and SE and their role in the development of cancer.

show abstract

Genotoxicity of vesicular fluid and saline extract of Taenia solium metacestodes in somatic cells of Drosophila melanogaster

Silva

Costa-Cruz

Spanó

et al. 2006

Environ and Mol Mutagen

View full text Add to dashboard Cite

show abstract

Induction of DNA damage in human lymphocytes treated with a soluble factor secreted byTaenia solium metacestodes

Tato

Molinari

Pérez

et al. 2003

Teratog. Carcinog. Mutagen.

View full text Add to dashboard Cite

We have previously reported that a factor secreted by the metacestode of Taenia solium (MF) is able to transform Syrian hamster embryo cells. The aim of this study was to analyze the genotoxicity of MF in cultured human lymphocytes using the micronucleus assay. Results show a significantly high frequency of micronucleated cells in lymphocyte cultures treated with MF. Although further experiments are needed to determine whether this factor is also secreted by T. solium metacestodes in humans, analysis of the frequency of micronucleus induced in cultured human lymphocytes indicates that DNA instability induced by MF could represent a risk for malignant transformation.

show abstract

Taenia solium: A Cysteine Protease Secreted by Metacestodes Depletes Human CD4 Lymphocytes in Vitro

Molinari¹,

Mejia²,

White

et al. 2000

Experimental Parasitology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Suppression of murine lymphocyte proliferation induced by a small RNA purified from theTaenia solium metacestode

Cited by 34 publications

References 29 publications

Genotoxicity of vesicular fluid and saline extract of Taenia solium metacestodes in somatic cells of Drosophila melanogaster

Genotoxicity of vesicular fluid and saline extract of Taenia solium metacestodes in somatic cells of Drosophila melanogaster

Induction of DNA damage in human lymphocytes treated with a soluble factor secreted byTaenia solium metacestodes

Taenia solium: A Cysteine Protease Secreted by Metacestodes Depletes Human CD4 Lymphocytes in Vitro

Contact Info

Product

Resources

About