Suppression of motor conditioning by the injection of 3 M KCl in the caudate nuclei of cats

Prado‐Alcalá, Roberto A.; Grinberg-Zylberbaum, J.; Alvarez-Leefmans, J.; Brust-Carmona, H.

doi:10.1016/0031-9384(73)90086-3

Cited by 28 publications

(2 citation statements)

References 14 publications

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“…In monkeys, it was previously shown that lesions located in the anterior portion of the caudate nucleus caused task switching impairments during working memory tasks (Rosvold et al, 1958 ) and inhibitory tasks (Battig et al, 1962 ). In cats, similar types of lesions resulted in impairments in the early stage of learning or retrieval of stimulus-response associations (Prado-Alcala et al, 1973 ; Prado-Alcalá and Cobos-Zapiaín, 1979 ). Furthermore, caudate lesions were shown to introduce behavior of perseverance in the face of two potential responses (Olmstead and Villablanca, 1979 ).…”

Section: Anatomical Descriptionmentioning

confidence: 98%

Neuroimaging studies of the striatum in cognition Part I: healthy individuals

Provost

Hanganu

Monchi

2015

Front. Syst. Neurosci.

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The striatum has traditionally mainly been associated with playing a key role in the modulation of motor functions. Indeed, lesion studies in animals and studies of some neurological conditions in humans have brought further evidence to this idea. However, better methods of investigation have raised concerns about this notion, and it was proposed that the striatum could also be involved in different types of functions including cognitive ones. Although the notion was originally a matter of debate, it is now well-accepted that the caudate nucleus contributes to cognition, while the putamen could be involved in motor functions, and to some extent in cognitive functions as well. With the arrival of modern neuroimaging techniques in the early 1990, knowledge supporting the cognitive aspect of the striatum has greatly increased, and a substantial number of scientific papers were published studying the role of the striatum in healthy individuals. For the first time, it was possible to assess the contribution of specific areas of the brain during the execution of a cognitive task. Neuroanatomical studies have described functional loops involving the striatum and the prefrontal cortex suggesting a specific interaction between these two structures. This review examines the data up to date and provides strong evidence for a specific contribution of the fronto-striatal regions in different cognitive processes, such as set-shifting, self-initiated responses, rule learning, action-contingency, and planning. Finally, a new two-level functional model involving the prefrontal cortex and the dorsal striatum is proposed suggesting an essential role of the dorsal striatum in selecting between competing potential responses or actions, and in resolving a high level of ambiguity.

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Section: Anatomical Descriptionmentioning

confidence: 98%

Neuroimaging studies of the striatum in cognition Part I: healthy individuals

Provost

Hanganu

Monchi

2015

Front. Syst. Neurosci.

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“…It has been shown, for example, that interference with the activity of the amygdala (AMY) (Liang et al, 1982; Power et al, 2000; Roesler et al, 2000; McGaugh, 2002; Roozendaal et al, 2009), striatum (STR) (Prado-Alcalá et al, 1972, 1973; Sanberg et al, 1978; Prado-Alcalá, 1995; Salado-Castillo et al, 1996; Ambrogi-Lorenzini et al, 1999; Packard and Knowlton, 2002; White and McDonald, 2002; Izquierdo et al, 2006; White, 2009; Miyoshi et al, 2012), and substantia nigra (SN) (Routtenberg and Holzman, 1973; Kim and Routtenberg, 1976; Ambrogi-Lorenzini et al, 1994; Da Cunha et al, 2001, 2003; Díaz del Guante et al, 2004) causes significant deficiencies in retention of inhibitory avoidance (IA). There are data that indicate, however, that treatments which normally induce amnesia become ineffective when infused into these structures in rats that have been subjected to enhanced IA training (Giordano and Prado-Alcalá, 1986; Pérez-Ruíz and Prado-Alcalá, 1989; Parent et al, 1992, 1994, 1995; Parent and McGaugh, 1994; Prado-Alcalá, 1995; Cobos-Zapiaín et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Enhanced training protects memory against amnesia produced by concurrent inactivation of amygdala and striatum, amygdala and substantia nigra, or striatum and substantia nigra

Salado‐Castillo

Sanchez‐Alavez

Quírarte

et al. 2011

Front. Behav. Neurosci.

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Memory is markedly impaired when normal activity of any of a number of cerebral structures is disturbed after a learning experience. A growing body of evidence indicates, however, that such interference with neuronal function becomes negligible when the learning experience is significantly enhanced. We now report on the effects of enhanced training on retention after temporary inactivation of cerebral nuclei known to be involved in memory, namely the substantia nigra (SN), striatum (STR), and amygdala (AMY). When training was conducted with a relatively low intensity of footshock (1.0 mA), post-training infusion of lidocaine into the SN, STR, or AMY produced a marked memory deficit. Increasing the aversive stimulation to 2.0 mA protected memory from the amnesic effect of intranigral lidocaine, but there was still a deficit after its infusion into the STR and AMY. Administration of lidocaine into each of these nuclei, in the groups that had been trained with 3.0 mA, was completely ineffective in producing alterations in memory consolidation. Simultaneous infusion of lidocaine into STR + SN, AMY + SN, or AMY + STR was also ineffective in altering memory formation when the highest footshock intensity was used for training. To our knowledge, this is the first demonstration that an enhanced learning experience guards against memory deficits after simultaneous temporary interruption of neural activity of brain nuclei heretofore thought to be necessary for memory formation. These findings support the proposition that brain structures involved in memory processing are functionally connected in series during memory consolidation and that, after an enhanced learning experience, these structures become functionally connected in parallel.

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Effects of laser guided by optic fiber into rat brain on conditioned avoidance response and brain chemistry

et al. 1983

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Low power lasers were guided by optic fibers into the rat caudate nucleus or frontal cortex, during conditioned avoidance response (CAR) training. The changes in striatal monoamine and amino acid concentrations were subsequently determined. Of six training groups tested, only the experimental group with helium-neon laser radiation to the caudate nucleus exhibited the formation of CAR and an increase of unconditioned leg contractions. The striatal concentrations of dopamine (DA) and norepinephrine (NE) were increased simultaneously in the group.

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Suppression of motor conditioning by the injection of 3 M KCl in the caudate nuclei of cats

Cited by 28 publications

References 14 publications

Neuroimaging studies of the striatum in cognition Part I: healthy individuals

Neuroimaging studies of the striatum in cognition Part I: healthy individuals

Enhanced training protects memory against amnesia produced by concurrent inactivation of amygdala and striatum, amygdala and substantia nigra, or striatum and substantia nigra

Effects of laser guided by optic fiber into rat brain on conditioned avoidance response and brain chemistry

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