Suppression of Immunologic Responses

Makinodan, Takashi; Albright, Joseph F.; Perkins, Eugene H.; Nettesheim, Paul

doi:10.1016/s0025-7125(16)33247-3

Cited by 29 publications

(9 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The latter hypothesis is supported by the finding that a single injection of endotoxin, even when given 7 days prior to antigen, effectively inhibits the production of antibody, and also by histological observations (9) revealing a conspicuous lack of cellular changes characteristic of a primary response to sheep red ceils in the lymphoid tissues of the experimentally inhibited mice. Whether these inhibitory effects are comparable to the immunosuppressive action of potent metabolic inhibitors (29), as suggested by a report of the inhibitions by 6-mercaptopurine of an immune response to foreign erythrocytes in mice (30), is still to be established. Although lipopolysaccharides are good antigens and induce the production of specific antibodies (31), it is unlikely that the marked decrease of anti-sheep red cell hemolysin production evoked by single injections of relatively small amounts of these compounds can be explained by the immunological phenomena of antigen competition (32).…”

Section: Discussionmentioning

confidence: 96%

The Primary Immune Response in Mice

Franzl

McMaster

1968

The Journal of Experimental Medicine

102

View full text Add to dashboard Cite

It is well known that macrophages of the reticuloendothelial system take up antigens before the initiation of the immune response (1) and that injections of bacterial endotoxins first depress and then stimulate the phagocytic activity of these cells (2, 3). In view of these facts, a study has been made of the influence of a Salmonella typhosa endotoxin on the production of specific immunoglobulins, in the hope of learning something more about the role of phagocytic cells in the process of antibody formation. A particulate antigen, the sheep red blood cell, was employed in this investigation so that changes in the uptake and processing of antigen might more readily be reflected as differences in the resulting formation of antibodies. When the endotoxin was given simultaneously with this antigen, the adjuvant effect on antibody formation previously described by others using soluble antigens (4, 5) was promptly confirmed.On the other hand when the bacterial preparation was allowed to exert a more sustaining action and was given prior to the particulate antigen, it was found to suppress instead of enhance the production of hemolysins. This surprising effect, which in many instances resulted in the complete inhibition of antibody production, was realized by employing appropriate time intervals between the injection of endotoxin and the particulate antigen, and suitable routes of administration of these agents. These results are detailed in the present paper together with other serological findings on the effects of endotoxin on hemolysin production in mice. Subsequent to a preliminary communication of these findings (6), others (7,8) have also reported that, under specified conditions, bacterial endotoxins will inhibit the production of antibodies to particulate antigens.The pronounced inhibition and enhancement of antibody formation, which could be brought about at will by the proper use of endotoxin, offered an excellent opportunity to investigate the cellular changes in the antibody-forming

show abstract

Section: Discussionmentioning

confidence: 96%

The Primary Immune Response in Mice

Franzl

McMaster

1968

The Journal of Experimental Medicine

102

View full text Add to dashboard Cite

show abstract

“…The current study is based on a model stipulating that genomic alterations intrinsic to immune cells and environmental alterations extrinsic to immune cells reduce immunity in older adults 8 . This is of particular relevance because recent studies have suggested that disease states that alter the cytokine microenvironment have a marked influence on key regulatory immune cells such as dendritic cells 9 .…”

mentioning

confidence: 99%

Comorbidity Is a Better Predictor of Impaired Immunity than Chronological Age in Older Adults

Castle

Uyemura

Rafi

et al. 2005

J American Geriatrics Society

View full text Add to dashboard Cite

show abstract

“…Received for publication 13 August 1968 and in revised form 21 December 1968. response after immunization with tetanus (3). Spontaneous isoagglutinin levels and antibody to Proteus OX-2 were found by Muschel (4) to be normal whereas ASO levels were lower than in controls.…”

mentioning

confidence: 99%

“…However, no significant correlation between the steroid dosage and whole serum, 19S or 7S antibody titers to Brucella antigen was found in the SLE group. Inhibition of antibody production by steroids has been investigated in a number of species, using a variety of antigens (21,22). Mild suppression of the primary response in the mouse and rat has usually required doses of from 100 to 200 mg/kg of prednisolone.…”

mentioning

confidence: 99%