Suppression of hypercholesterolemia in hepatoma‐bearing rats by cabbage extract and its component, <i>S</i>‐methyl‐<scp>l</scp>‐cysteine sulfoxide

Komatsu, Wataru; Miura, Yutaka; Yagasaki, Kazumi

doi:10.1007/s11745-998-0233-7

Cited by 76 publications

(44 citation statements)

References 21 publications

(27 reference statements)

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“…Cabbage is one of the most popular Brassica vegetables. Cabbage extracts have been reported to have a variety of biological activities, including anticarcinogenic properties (19,20), suppression of hypercholesterolemia in hepatoma-bearing rats (21), and antiulcerogenic activity (22). Many of these beneficial effects of cabbages have been partly attributed to the high content of organosulfur compounds, including isothiocyanates (23).…”

Section: Discussionmentioning

confidence: 99%

Toll-like Receptors as a Target of Food-derived Anti-inflammatory Compounds

Shibata

Nakashima

Honda

et al. 2014

Journal of Biological Chemistry

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Background: Vegetable-rich diets are associated with the reduced risk of inflammatory diseases. Results: Iberin, an isothiocyanate compound from cabbage, targeted TLRs, disrupted TLR dimerization, and inhibited the inflammatory responses. Conclusion: The TLR dimerization step is a target of food-derived anti-inflammatory compounds. Significance: These findings extend our understanding of how isothiocyanates show their medical benefits as anti-inflammatory food components.

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Section: Discussionmentioning

confidence: 99%

Toll-like Receptors as a Target of Food-derived Anti-inflammatory Compounds

Shibata

Nakashima

Honda

et al. 2014

Journal of Biological Chemistry

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“…3). The hypocholesterolemic actions of these two sulfur amino acids could be attributed to a restoration of decreased bile acid excretion into feces, like a Cys derivative, S-methyl-L-cysteine sulfoxide (29). In addition to these common actions of the two amino acids, Met restored the decreased HDL-Ch level in the hepatoma-bearing state to the normal level (Fig.…”

Section: Discussionmentioning

confidence: 96%

Effects of dietary methionine and cystine on lipid metabolism in hepatoma‐bearing rats with hyperlipidemia

Kawasaki

Funabiki

Yagasaki

1998

Lipids

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Abnormal lipid metabolism and its restoration by dietary methionine (Met) and cystine (Cys) were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line of AH109A. The hepatoma-bearing rats exhibited hyperlipidemia characterized by rises in serum triglyceride and cholesterol levels. Decreased lipoprotein lipase (LPL) activities in epididymal adipose tissue, cardiac muscle, and gastrocnemius as well as increased fatty acid mobilization from adipose tissue were considered to be responsible for the hepatoma-induced hypertriglyceridemia, while increased hepatic cholesterogenesis and decreased steroid excretion into feces were thought to be responsible for the hepatoma-induced hypercholesterolemia. Dietary-supplemented Met or Cys reduced the AH109A-induced hypertriglyceridemia with suppression of fatty acid synthesis in the host liver. Met restored the fall of LPL activities, while Cys did not. Dietary Met or Cys also reduced the hypercholesterolemia with restoration of decreased bile acid excretion into feces. These results suggest that dietary Met or Cys is hypolipidemic in the hepatoma-bearing rats with slight differences in their modes of action.

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“…Sulfone moieties are useful synthetic intermediates for the construction of various chemically and biologically active molecules including drugs, flavors, germicides as well as catabolism regulators [1][2][3][4][5][6][7][8][9]. Various methods for the selective oxidation of sulfides have been developed for this transformation [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Selective Oxidation of Sulfides to Sulfones by H2O2 Catalyzed by Fe-Substituted Sandwich Type Polyoxometalate

Haddadi

Farsani

2015

J Clust Sci

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Catalytic activity of the sandwich-type heteropolytungstates ([(XW 9 O 39 )M 4 ] (n-m)-, where X = P, Si, As and M = Mn, Fe, Co, Ni, Cu and Zn) in the selective oxidation of sulfides to corresponding sulfone with aqueous H 2 O 2 have been studied in acetonitrile. In comparison, different sandwich type polyoxometalates with various transition metals substituted and heteroatoms, TBAPWFe was found to be more active to each other's. This catalyst with 2.5 equivalent of hydrogen peroxide, converted various sulfides to the corresponding sulfone with 96.8-99 % selectivity at 94-97 % conversion. Furthermore, for oxidizing various sulfides to the corresponding sulfone, the sulfide function is highly reactive and other functional groups such as the double bond and hydroxyl group are tolerable. This catalyst indicated very good reusability in the oxidation reaction.

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Suppression of hypercholesterolemia in hepatoma‐bearing rats by cabbage extract and its component, S‐methyl‐l‐cysteine sulfoxide

Cited by 76 publications

References 21 publications

Toll-like Receptors as a Target of Food-derived Anti-inflammatory Compounds

Toll-like Receptors as a Target of Food-derived Anti-inflammatory Compounds

Effects of dietary methionine and cystine on lipid metabolism in hepatoma‐bearing rats with hyperlipidemia

Selective Oxidation of Sulfides to Sulfones by H2O2 Catalyzed by Fe-Substituted Sandwich Type Polyoxometalate

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