1987
DOI: 10.7164/antibiotics.40.1065
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Suppression of humoral immunity in dogs by 15-deoxyspergualin.

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Cited by 21 publications
(6 citation statements)
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“…The severity of leucopenia seems to be proportional to the dose and duration of treatment and may be caused by a cytostatic effect on haematopoietic stem cells, where the proliferation and differentiation of immature bone marrow cells is suppressed [26,27]. The reduction in B-cell fraction seen in our patients is particularly interesting since it is in accordance with previous reports showing inhibitory effects on antibody responses in mice [4,6,18,25] and dogs [23]. Although this study provides no information on antibody production, it indicates that human B cells are also affected.…”
Section: Discussionsupporting
confidence: 90%
“…The severity of leucopenia seems to be proportional to the dose and duration of treatment and may be caused by a cytostatic effect on haematopoietic stem cells, where the proliferation and differentiation of immature bone marrow cells is suppressed [26,27]. The reduction in B-cell fraction seen in our patients is particularly interesting since it is in accordance with previous reports showing inhibitory effects on antibody responses in mice [4,6,18,25] and dogs [23]. Although this study provides no information on antibody production, it indicates that human B cells are also affected.…”
Section: Discussionsupporting
confidence: 90%
“…They reported that while DSG was highly effective in inhibiting the primary immunoresponse and the development of memory, it was less effective in inhibiting an established immunoresponse. In other experimental studies, DSG has been shown to inhibit antibody responses [15,17,25]. When DSG was given to recipients after heart transplantation, it successfully suppressed the proliferation of B cells (sensitization inter-val 2 weeks) and class I1 antigen-positive cells (sensitization interval 6 months), resulting in prolonged allograft survival.…”
Section: Discussionmentioning
confidence: 99%
“…The influence of DSG on the immune system reportedly involves suppression of the mixed lymphocyte reaction (MLR), 9 action on cytotoxic T lymphocytes, 10 antibody formation by B cells, 11 and sparing of suppressor cells. 12 However, the immunological effect of this drug on activated T lymphocytes is not clear and is still controversial.…”
Section: Introductionmentioning
confidence: 99%