1999
DOI: 10.1007/s101570050005
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Influence of 15-deoxyspergualin on activated lymphocytes: Comparison of heart and renal rat transplantation models

Abstract: Background. Among the immunological effects of 15-deoxyspergualin (DSG), its action on activated T lymphocytes with the interleukin 2 receptor (IL-2R) is controversial. Materials and methods. To investigate this action, we used rat heart and rat renal transplantation models in which Brown Norway rats (BN) served as the organ donors and Lewis rats (LEW) as the organ recipients. DSG was administered intraperitoneally to the recipients immediately after the operation. The percentage of IL-2R-positive cells and of… Show more

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