Suppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF‐κB inhibitor

Abstract

These findings suggest that the activation of NF-kappaB plays an important role in the pathogenesis of endotoxemia and viral myocarditis, and that the NF-kappaB inhibitor, SUN C8079, may be therapeutic in these disorders.

Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin

“…NF-κB inhibitor suppressed the expressions of cardiac TNF-α in vivo and vitro and prevented the development of myocarditis [30]. It was also reported that adiponectin reduced the activation of NF-κB [31]. The AT1-receptor blocker significantly attenuated expression of TNF-α and activation of NF-κB [8].…”

Gelam honey inhibits lipopolysaccharide-induced endotoxemia in rats through the induction of heme oxygenase-1 and the inhibition of cytokines, nitric oxide, and high-mobility group protein B1

“…The mechanism by which honey inhibits both pro-inflammatory cytokines (such as TNF-α and IL-1β), and NO is unclear, but it may involve the inhibition of NF-κB. A previous study shows that NF-κB prevents the release pro-inflammatory cytokines and inhibits the release of iNOS [27,28]. However, the inhibitory effect of honey on the anti-inflammatory cytokine, IL-10, remains a matter for speculation.…”

Attenuation of virus-induced myocardial injury by inhibition of the angiotensin II type 1 receptor signal and decreased nuclear factor-kappa B activation in knockout mice

“…We have previously reported that pimobendan, a phosphodiesterase inhibitor, protects against viral myocarditis through its inhibition of NF-kB activation (17,18). We have also recently found that NF-kB inhibitor prevents the development of EMCV myocarditis and inhibits the expression of proinflammatory cytokines in cardiac tissues (19).…”