Gelam honey inhibits lipopolysaccharide-induced endotoxemia in rats through the induction of heme oxygenase-1 and the inhibition of cytokines, nitric oxide, and high-mobility group protein B1

Kassim, Mustafa; Yusoff, Kamaruddin Mohd; Ong, Gracie; Sekaran, Shamala Devi; Yusof, Mohd Yasim Bin Md; Mansor, Marzida

doi:10.1016/j.fitote.2012.05.008

Cited by 55 publications

(37 citation statements)

References 41 publications

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“…Gallic acid can suppress iNOS and COX2 and diminish the production of proinflammatory cytokines and histamine release in macrophages (28). In addition, Kassim et al reported that honey induced heme oxygenase-1, which inhibits NF-κB and iNOS and attenuated NO, IL-1β, and TNF-α generation in LPS-induced endotoxemia rats (44). COX2, IL-6, and TNF-α expression reduced in mice receiving chrysin before the induction of colitis (30).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Rezaei

Eftekhari

Tanideh

et al. 2018

Iran Red Crescent Med J

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Background: Overproduction of reactive oxygen species (ROS) causes increased lipid peroxidation, decreased intestinal epithelial barrier integrity, and ultimately mucosal disruption and ulceration. Several studies have confirmed the antioxidant, antiinflammatory, and immunomodulatory properties of Spirulina Platensis (SP), edible blue -green algae, in various inflammatory diseases. In addition, natural honey, a source of phenolic and flavonoid compounds, is a powerful antioxidant, which can help prevent chronic oxidative stress and subsequent inflammation. Objectives: In this study, we examined and compared the protective effects of SP and honey on ulcerative colitis induced by acetic acid (AA) in rats. Methods: Forty male rats were allocated into five groups (N = 8) and received pretreatment for 32 consecutive days. The administrations were as follows: group 1 (control) and group 2 (AA-colitis group): normal saline, group 3: 1 ml honey/day, group 4: 1 ml honey/day plus 1 g/kg SP, and group 5: 1 g/kg SP. Colitis was induced on the 30th day in groups 2 to 5. On day 32, the clinical activity was determined and anesthetized animals were sacrificed. Serum interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant capacity (TAC), superoxide dismutase (SOD), colonic tissues myeloperoxidase (MPO), prostaglandin E2 (PGE2), malondialdehyde (MDA), nitric oxide (NO), and colonic weight/length ratio were determined. In addition, histopathological changes of the colon were observed microscopically.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Rezaei

Eftekhari

Tanideh

et al. 2018

Iran Red Crescent Med J

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“…In addition to these properties, honey promotes angiogenic activity, which is important in wound healing mechanisms, and also induces the formation of granulation tissue as well as skin reepithelialization [23,24]. Several studies have indicated other fascinating bioactivities of honey such as antinociceptive [25,26], immunomodulatory [27,28], and nematicidal activities [29,30]. The main active mechanisms of honey that are involved in the healing of wounds are its antioxidant, antibacterial, and anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Stingless Bee Honey, the Natural Wound Healer: A Review

Jalil¹,

Kasmuri²,

Hadi³

2017

Skin Pharmacol Physiol

163

138

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Background: The stingless bee is a natural type of bee that exists in almost every continent. The honey produced by this bee has been widely used across time and space. The distinctive feature of this honey is that it is stored naturally in the pot (cerumen), thus contributing to its beneficial properties, especially in the wound healing process. Methods: In this article, several studies on stingless bee honey that pointed out the numerous therapeutic profiles of this honey in terms of its antioxidant, antimicrobial, anti-inflammatory, as well as moisturizing properties are reviewed. All of these therapeutic properties are related to wound healing properties. Results: Antioxidant in stingless bee honey could break the chain of free radicals that cause a detrimental effect to the wounded area. Furthermore, the antimicrobial properties of stingless bee honey could overcome the bacterial contamination and thus improve the healing rate. Moreover, the anti-inflammatory attribute in this honey could protect the tissue from highly toxic inflammatory mediators. The moisturizing properties of the honey could improve wound healing by promoting angiogenesis and oxygen circulation. Conclusion: The application of honey to the wound has been widely used since ancient times. As a result, it is essential to understand the pharmacological mechanism of the honey towards the physiology of the wounded skin in order to optimize the healing rate in the future.

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“…Lipopolysaccharide (LPS), an important cell-wall component of gram-negative bacteria and a potent inducer of the host immune system, causes endotoxemia (1). LPS administration induces systemic inflammation characterized by increases in proinflammatory cytokines without bacteremia (2).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of β-glucan on acute lung injury induced bylipopolysaccharide in rats

Iraz¹,

Eşrefoğlu²,

Aydın³

2015

Turk J Med Sci

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Background/aim: Lipopolysaccharide (LPS)-induced endotoxemia can cause serious organ damage such as acute lung injury and death by triggering the secretion of proinflammatory cytokines and acute-phase reactants. The goal of this study was to evaluate the effects of β-glucan on inflammatory mediator levels and histopathological changes in LPS-induced endotoxemia. Materials and methods:Forty-seven male Wistar albino rats were randomly allocated into four groups as follows: control group, LPS group (10 mg/kg LPS), LPS + β-glucan group (100 mg/kg β-glucan before LPS administration), and β-glucan group. Twelve hours after LPS administration, lung and serum samples were collected. Concentrations of IL-6, IL-8, C-reactive protein (CRP), and procalcitonin were measured in the serum at hours 0 (basal) and 12. The severity of lung damage was assessed by an appropriate histopathological scoring system. Results: Serum levels of CRP in the LPS group at 12 h were significantly higher than in the other groups, whereas serum IL-6 levels in the LPS and LPS + β-glucan groups at 12 h were significantly decreased. The mean histopathological damage score of the LPS group was slightly higher than that of the LPS + β-glucan group. Moreover, mortality rate was significantly decreased in the LPS + β-glucan group versus the LPS group.Conclusion: β-Glucan reduces endotoxemia-induced mortality and might be protective against endotoxemia-induced lung damage.

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Gelam honey inhibits lipopolysaccharide-induced endotoxemia in rats through the induction of heme oxygenase-1 and the inhibition of cytokines, nitric oxide, and high-mobility group protein B1

Cited by 55 publications

References 41 publications

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Stingless Bee Honey, the Natural Wound Healer: A Review

Protective effect of β-glucan on acute lung injury induced bylipopolysaccharide in rats

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