Suppression of both basal and antigen-induced lipid peroxidation in ring dove heterophils by melatonin

Rodríguez, Ana B.; Nogales, G.; Marchena, Jose M.; Ortega, Eduardo; Barriga, C.

doi:10.1016/s0006-2952(99)00207-5

Cited by 26 publications

(15 citation statements)

References 37 publications

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“…*Significant difference from all other groups using one-way ANOVA followed by Bonferroni post hoc test (P<0.05) during SD. In fact, melatonin has the ability to neutralize free radicals [69] and to prevent tissue damage associated with oxidative stress by utilizing different mechanisms that include scavenging the free radicals [70][71][72], increasing mRNA levels and activities of several important antioxidant enzymes, including SOD and glutathione [73], and preventing free radical formation at the mitochondrial level by reducing the leakage of electrons from the electron transport chain [74]. Thus, current results highlight the importance of using antioxidants such as melatonin in relieving some of the deleterious effects of SD on individual health.…”

Section: Discussionmentioning

confidence: 99%

Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation

et al. 2015

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Sleep deprivation (SD) has been associated with memory impairment through induction of oxidative stress. Melatonin, which promotes the metabolism of many reactive oxygen species (ROS), has antioxidant and neuroprotective properties. In this study, the effect of melatonin on memory impairment induced by 4 weeks of SD was investigated using rat animal model. Animals were sleep deprived using modified multiple platform model. Melatonin was administered via oral gavage (100 mg/kg/day). Spatial learning and memory were assessed using the radial arm water maze (RAWM). Changes in oxidative stress biomarkers in the hippocampus following treatments were measured using ELISA procedure. The result revealed that SD impaired both short- and long-term memory (P < 0.05). Use of melatonin prevented memory impairment induced by SD. Furthermore, melatonin normalized SD-induced reduction in the hippocampus activity of catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD). In addition, melatonin enhanced the ratio of reduced to oxidized glutathione GSH/GSSG in sleep-deprived rats (P < 0.05) without affecting thiobarbituric acid reactive substance (TBARS) levels (P > 0.05). In conclusion, SD induced memory impairment, which was prevented by melatonin. This was correlated with normalizing hippocampus antioxidant mechanisms during chronic SD.

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Section: Discussionmentioning

confidence: 99%

Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation

et al. 2015

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“…While the anti-inflammatory activity of Mel in mammals has been well documented (for review see Cuzzocrea and Reiter, 2001), data on Mel actions in birds are rather scanty. Nevertheless, its anti-oxidative activity was indicated by in vitro studies in ring-dove (Rodriguez et al, 1999(Rodriguez et al, , 2001 as well as in vivo in chickens, where a pharmacological dose of Mel exerted a protective effect against the immunotoxicity of airborne dust particles (Bultowicz et al,Fig. 2.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and opioid-mediated effects of melatonin on experimental peritonitis in chickens

et al. 2005

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“…In the ring dove ( Streptopelia risoria ), our research group has found a positive correlation between the circadian rhythm of melatonin and the capacity of blood heterophils to phagocytose inert particles (latex beads), as well as a negative correlation between the neurohormone and superoxide anion levels during the respiratory burst (8). We have also observed an increase in the capacity to ingest inert particles on incubating avian heterophils with both pharmacological concentrations (10) and physiological concentrations (11–13) of melatonin, together with a decline in superoxide anion levels, a modulation of the superoxide dismutase (SOD) activity (5), and a clear decline in lipid peroxidation (14). Thus, the phagocytic function is enhanced without a concomitant increase in superoxide anion levels; indeed quite the contrary.…”

Section: Introductionmentioning

confidence: 99%

Phagocytosis ofCandida albicansand Superoxide Anion Levels in Ring Dove (Streptopelia risoria) Heterophils: Effect of Melatonin

Terrón

Juánez

Barriga

et al. 2003

J Neuroendocrinology

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We observed in previous studies on avian heterophils that incubation with either physiological or pharmacological concentrations of the neurohormone melatonin increased the phagocytosis of inert particles (latex beads), and also provoked a decline in superoxide anion levels of those phagocytes. In the present study, we wanted to corroborate whether melatonin acts on the oxidative metabolism that accompanies the respiratory burst during phagocytosis by inducing a more effective phagocytic activity at the same time as exerting an antioxidant effect to eliminate and/or scavenge the free radicals left over after the destruction of the foreign material. To this end, we evaluated the ingestion and destruction of Candida albicans (live particles) by ring dove (Streptopelia risoria) heterophils after different times of incubation (30 and 60 min) with physiological concentrations of melatonin (50 pg/ml diurnal and 300 pg/ml nocturnal), as well as with a pharmacological concentration 23 x 106 pg/ml (100 micro m) of the hormone. In parallel, using the same times of incubation, we evaluated the oxidative metabolism by determining the superoxide anion levels (O2-.). The results show that melatonin, at all the times and concentrations studied, increases both the phagocytosis index (number of C. albicans phagocytosed by 100 heterophils) and the candidicide power (percentage of C. albicans killed of those ingested by 100 heterophils). The effect was dose-dependent. With respect to the oxidative metabolism accompanying the digestion and destruction, there was a decline in superoxide anion levels after incubation with all of the concentrations of the hormone studied. The effect was dose-dependent and most pronounced at 60 min. These results thus corroborate the proposal that melatonin enhances the phagocytic function at the same time as neutralizing the oxidative stress derived from this immune function.

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Suppression of both basal and antigen-induced lipid peroxidation in ring dove heterophils by melatonin

Cited by 26 publications

References 37 publications

Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation

Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation

Anti-inflammatory and opioid-mediated effects of melatonin on experimental peritonitis in chickens

Phagocytosis ofCandida albicansand Superoxide Anion Levels in Ring Dove (Streptopelia risoria) Heterophils: Effect of Melatonin

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