Abstract:We found sustained activation of the proto-oncogene c-los in neurons of the medial and dorsal neostriatum and suppression of this activation in NO-synthase (NOS)-containing cells within the islands of Calleja after unilateral lesions of the dopaminergic mestmtriatal system induced by 6-hydroxydopamine (6-OHDA). Systemic administration of nitroglycerin (NTG) resulted in a decreased expression of c-Fos protein in the dorsal part of the denervated neostriatum: respective numbers of Fos-positive neuronal nuclei we… Show more
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