Suppressing activity of staurosporine from <i>Streptomyces</i>
 sp. MJM4426 against rice bacterial blight disease

Cheng, Jinhua; Park, Sait Byul; Kim, Seunghwan; Yang, Seung Hwan; Suh, Joo‐Won; Lee, Choong Hwan; Kim, Jeong Gu

doi:10.1111/jam.13034

Cited by 13 publications

(9 citation statements)

References 40 publications

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“…AM‐2282 (the originally described staurosporine producer, now Lentzea albida AM‐2282) has been reported after 72 hr cultivation in a medium containing glucose 3%, soybean meal 1.5%, and CaCO 3 0.4% for 72 hr (Omura et al, ). Several other species of Streptomyces have been reported to produce staurosporine and its derivatives with comparable or lower titers (Cheng et al, ; Li et al, ; Onaka, Taniguchi, Igarashi, & Furumai, ; Park et al, ; Zhou, Qin, Ding, & Ma, ). Staurosporine has also been isolated from the marine ascidian Cystodytes solitus (Reyes et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties

et al. 2020

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Applying a bioactivity‐guided isolation approach, staurosporine was separated and identified as the active principle in the culture extract of the new isolate Streptomyces sp. BV410 collected from the chamomile rhizosphere. The biotechnological production of staurosporine by strain BV410 was optimized to yield 56 mg/L after 14 days of incubation in soy flour–glucose–starch–mannitol‐based fermentation medium (JS). The addition of FeSO4 significantly improved the staurosporine yield by 30%, while the addition of ZnSO4 significantly reduced staurosporine yield by 62% in comparison with the starting conditions. Although staurosporine was first isolated in 1977 from Lentzea albida (now Streptomyces staurosporeus) and its potent kinase inhibitory effect has been established, here, the biological activity of this natural product was assessed in depth in vivo using a selection of transgenic zebrafish (Danio rerio) models, including Tg(fli1:EGFP) with green fluorescent protein‐labeled endothelial cells allowing visualization and monitoring of blood vessels. This confirmed a remarkable antiangiogenic activity of the compound at doses of 1 ng/ml (2.14 nmol/L) which is below doses inducing toxic effects (45 ng/ml; 75 nmol/L). A new, efficient producing strain of commercially significant staurosporine has been described along with optimized fermentation conditions, which may lead to optimization of the staurosporine scaffold and its wider applicability.

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Section: Discussionmentioning

confidence: 99%

“…to produce staurosporine and its derivatives with comparable or lower titers (Cheng et al, 2016;Onaka, Taniguchi, Igarashi, & Furumai, 2002;Park et al, 2006;Zhou, Q in, Ding, & Ma, 2018). Staurosporine has also been isolated from the marine ascidian Cystodytes solitus (Reyes et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties

et al. 2020

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“…Streptomyces sp. MJM4426 can protect rice leaf explants from the infection of Xoo by producing staurosporine (Cheng et al, 2016). Streptomyces toxytricini VN08-A-12 was found, not only able to reduce the length of Xoo lesion in the two rice cultivars (the reduction of lesion length was up to 38.3%), but also significantly reduced the loss of Xoo-related yield in infected rice cultivars from the field (yield loss reduction of up to 43.2%) (Van Hop et al, 2014).…”

Section: Introductionmentioning

confidence: 94%

Inhibitory Effects of Carbazomycin B Produced by Streptomyces roseoverticillatus 63 Against Xanthomonas oryzae pv. oryzae

et al. 2021

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The present manuscript highlights the potential role of Streptomyces roseoverticillatus 63 (Sr-63) against Xanthomonas oryzae pv. oryzae (Xoo), which is the cause of a disastrous bacterial leaf blight disease with rice worldwide. The disease suppression was achieved under greenhouse conditions. A foliar spray of the fermentation broth of Sr-63 significantly reduced the leaf blight symptoms with rice in Xoo inoculated rice plants. Furthermore, we observed that the carbazomycin B, isolated from the fermentation broth of Sr-63, was demonstrated to have antibacterial activity against Xoo with a minimum inhibitory concentration (MIC) of 8 μg mL–1. The results indicated that carbzomycin B hampered the membrane formation of Xoo, reduced the production of xanthomonadin and extracellular polymeric substance (EPS). The fourier transform infrared spectroscopic (FT-IR) indicated that carbazomycin B changed the components of the cell membrane, then caused a change of the cell surface hydrophobicity of Xoo. Scanning electron microscopy revealed that the Xoo cells treated with carbazomycin B exhibited apparent structural deformation. The results also indicated that carbazomycin B had a negative impact on the metabolism of Xoo, carbazomycin B reduced the activity of malate dehydrogenase (MDH) activity and suppressed the protein expression of Xoo. Overall, our data suggests that Streptomyces roseoverticillatus 63 is a promising biocontrol agent that could be used to combat the bacterial leaf blight diseases of rice.

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“…Staurosporine from Streptomyces sp. MJM4426 showed biocontrol potential on rice bacterial blight . Antifungalmycin 702, a new polyene macrolide antibiotic from Streptomyces padanus JAU4234, suppressed rice blast pathogen .…”

Section: Discussionmentioning

confidence: 99%

Isolation and evaluation of endophytic Streptomyces endusOsiSh‐2 with potential application for biocontrol of rice blast disease

Zeng

et al. 2016

J Sci Food Agric

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Suppressing activity of staurosporine from Streptomyces sp. MJM4426 against rice bacterial blight disease

Abstract: This is the first report that staurosporine can protect rice leaf against bacterial blight disease and showed the potential of Streptomyces sp. MJM4426 as an alternative to chemical bactericide for bacterial blight disease in rice.

Cited by 13 publications

References 40 publications

Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties

Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties

Inhibitory Effects of Carbazomycin B Produced by Streptomyces roseoverticillatus 63 Against Xanthomonas oryzae pv. oryzae

Isolation and evaluation of endophytic Streptomyces endusOsiSh‐2 with potential application for biocontrol of rice blast disease

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